{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:12:03Z","timestamp":1753877523179,"version":"3.41.2"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T00:00:00Z","timestamp":1725667200000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Good\u2019s syndrome (GS) is a rare adult-onset thymoma associated with acquired combined B-cell and T-cell immunodeficiency. It has similarities with Common variable immunodeficiency (CVID) in terms of hypogammaglobulinemia and significant risk of invasive bacterial and opportunistic infections. We still have a long way to go in understanding the pathogenesis of Good\u2019s syndrome. Here, we describe a case of a middle-aged female with thymoma and recurrent opportunistic infections. Clinico-laboratory evaluation led to a diagnosis of GS and she showed good response to intravenous immunoglobulin. Clinicians should be aware that thymoma can precede the onset of immunodeficiency.<\/jats:p>","DOI":"10.1093\/omcr\/omae102","type":"journal-article","created":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T12:23:31Z","timestamp":1725711811000},"source":"Crossref","is-referenced-by-count":0,"title":["Thymoma with recurrent opportunistic infections\u2014a case report"],"prefix":"10.1093","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3971-9082","authenticated-orcid":false,"given":"Sri Lasya","family":"Karjala","sequence":"first","affiliation":[{"name":"Apollo Hospitals Department of General Medicine, , Chennai 600 006, Tamilnadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9867-5038","authenticated-orcid":false,"given":"Satya Prasad","family":"Namala","sequence":"additional","affiliation":[{"name":"Apollo Hospitals Department of Hematology, , Chennai 600 006, Tamilnadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9721-6996","authenticated-orcid":false,"given":"Phani Krishna","family":"Machiraju","sequence":"additional","affiliation":[{"name":"Apollo Hospitals Department of Hematology, , Chennai 600 006, Tamilnadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabu","family":"Pandurangan","sequence":"additional","affiliation":[{"name":"Apollo Hospitals Department of Hematology, , Chennai 600 006, Tamilnadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,9,7]]},"reference":[{"key":"2024090709145809200_ref1","first-page":"245","article-title":"A clinical and experimental study of agammaglobulinemia","volume":"75","author":"Good","year":"1955","journal-title":"J Lancet"},{"key":"2024090709145809200_ref2","doi-asserted-by":"crossref","first-page":"e928659","DOI":"10.12659\/AJCR.928659","article-title":"Immunodeficiency and Thymoma: a case report on Good syndrome, a diagnosis frequently missed and forgotten","volume":"22","author":"Tang","year":"2021","journal-title":"Am J Case Rep"},{"key":"2024090709145809200_ref3","doi-asserted-by":"crossref","first-page":"679556","DOI":"10.3389\/fimmu.2021.679556","article-title":"When the Good syndrome goes bad: a systematic literature review","volume":"12","author":"Shi","year":"2021","journal-title":"Front Immunol"},{"key":"2024090709145809200_ref4","doi-asserted-by":"crossref","first-page":"e04136","DOI":"10.1002\/ccr3.4136","article-title":"Good's syndrome (immunodeficiency with thymoma): a separate entity with a broad classification: report of six cases and review of the literature","volume":"9","author":"Nabavi","year":"2021","journal-title":"Clin Case Rep"},{"key":"2024090709145809200_ref5","doi-asserted-by":"crossref","first-page":"815710","DOI":"10.3389\/fimmu.2021.815710","article-title":"Good's syndrome: time to move on from reviewing the past","volume":"12","author":"Kabir","year":"2022","journal-title":"Front Immunol"},{"key":"2024090709145809200_ref6","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.clim.2010.01.006","article-title":"Good\u2019s syndrome remains a mystery after 55 years: a systematic review of the scientific evidence","volume":"135","author":"Kelesidis","year":"2010","journal-title":"J Clin Immunol"},{"key":"2024090709145809200_ref7","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1586\/eci.09.43","article-title":"Role of B cells in common variable immune deficiency","volume":"5","author":"Ahn","year":"2009","journal-title":"Expert Rev Clin Immunol"},{"key":"2024090709145809200_ref8","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.3390\/biomedicines11061605","article-title":"Insights from a case of Good's syndrome (immunodeficiency with Thymoma)","volume":"11","author":"Paganelli","year":"2023","journal-title":"Biomedicines"}],"container-title":["Oxford Medical Case 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