{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:13:40Z","timestamp":1790871220086,"version":"4.1.0"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>An 83-year-old woman presented with disturbance of consciousness and hand tremor. She had taken lithium carbonate 300\u00a0mg\/day for bipolar disorder and magnesium oxide 660\u00a0mg\/day for constipation. Blood tests revealed lithium poisoning, hypermagnesemia and acute kidney injury. Computed tomography showed colonic obstruction caused by cancer of the descending colon. In the outpatient section, her blood pressure decreased to 89\/54\u00a0mmHg, and her heart rate dropped to 40\u00a0bpm. We considered that the obstructive ileus induced intravascular dehydration, which led to toxic serum concentrations of lithium and magnesium, triggering the emergence of severe arrythmia induced by sinus dysfunction. The patient was treated with fluid resuscitation and hemodialysis, followed by endoscopic stent replacement for the descending colon cancer obstruction. These treatments improved her general condition and alleviated the lithium poisoning, hypermagnesemia and colonic obstruction. Such a case is considered extremely rare.<\/jats:p>","DOI":"10.1093\/omcr\/omae107","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T19:18:23Z","timestamp":1726255103000},"source":"Crossref","is-referenced-by-count":5,"title":["A case of acute lithium poisoning and hypermagnesemia involving advanced colon cancer-induced colonic obstruction"],"prefix":"10.1093","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8247-483X","authenticated-orcid":false,"given":"Hideo","family":"Takayama","sequence":"first","affiliation":[{"name":"NHO Kanazawa Medical Center Division of Gastroenterology, , 1-1 Shimoishibikimachi, Kanazawa, Ishikawa 920-0939, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Komura","sequence":"additional","affiliation":[{"name":"NHO Kanazawa Medical Center Division of Gastroenterology, , 1-1 Shimoishibikimachi, Kanazawa, Ishikawa 920-0939, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Kawane","sequence":"additional","affiliation":[{"name":"NHO Kanazawa Medical Center Division of Gastroenterology, , 1-1 Shimoishibikimachi, Kanazawa, Ishikawa 920-0939, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Matsuo","sequence":"additional","affiliation":[{"name":"NHO Kanazawa Medical Center Division of Gastroenterology, , 1-1 Shimoishibikimachi, Kanazawa, Ishikawa 920-0939, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Kimura","sequence":"additional","affiliation":[{"name":"NHO Kanazawa Medical Center Division of Gastroenterology, , 1-1 Shimoishibikimachi, Kanazawa, Ishikawa 920-0939, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"NHO Kanazawa Medical Center Division of Gastroenterology, , 1-1 Shimoishibikimachi, Kanazawa, Ishikawa 920-0939, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoki","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"NHO Kanazawa Medical Center Division of Internal Medicine, , 1-1 Shimoishibikimachi, Kanazawa, Ishikawa 920-0939, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Omi","sequence":"additional","affiliation":[{"name":"NHO Kanazawa Medical Center Division of Internal Medicine, , 1-1 Shimoishibikimachi, Kanazawa, Ishikawa 920-0939, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Sakajiri","sequence":"additional","affiliation":[{"name":"NHO Kanazawa Medical Center Division of Internal Medicine, , 1-1 Shimoishibikimachi, Kanazawa, Ishikawa 920-0939, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Onishi","sequence":"additional","affiliation":[{"name":"NHO Kanazawa Medical Center Division of Surgery, , 1-1 Shimoishibikimachi, Kanazawa, Ishikawa 920-0939, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Sakagami","sequence":"additional","affiliation":[{"name":"NHO Kanazawa Medical Center Division of Internal Medicine, , 1-1 Shimoishibikimachi, Kanazawa, Ishikawa 920-0939, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Kanazawa University Division of Gastroenterology, , 13-1 Takaramachi, Kanazawa, Ishikawa 920-8641, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kagaya","sequence":"additional","affiliation":[{"name":"NHO Kanazawa Medical Center Division of Gastroenterology, , 1-1 Shimoishibikimachi, Kanazawa, Ishikawa 920-0939, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"key":"2024091309185971400_ref1","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1007\/s11255-023-03558-5","article-title":"Lithium poisoning and renal replacement therapy: pathophysiology and current clinical recommendations","volume":"55","author":"Spatola","year":"2023","journal-title":"Int Urol Nephrol"},{"key":"2024091309185971400_ref2","doi-asserted-by":"crossref","first-page":"17r02225","DOI":"10.4088\/PCC.17r02225","article-title":"Lithium neurotoxicity due to second-generation antipsychotics combined with lithium: a systematic review","volume":"21","author":"Netto","year":"2019","journal-title":"Prim Care Companion CNS Disord"},{"key":"2024091309185971400_ref3","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.jemermed.2008.02.064","article-title":"Adynamic ileus in chronic lithium intoxication","volume":"38","author":"Parale","year":"2010","journal-title":"J Emerg Med"},{"key":"2024091309185971400_ref4","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1007\/BF02087570","article-title":"Hypermagnesemia-induced paralytic ileus","volume":"39","author":"Golzarian","year":"1994","journal-title":"Dig Dis Sci"},{"key":"2024091309185971400_ref5","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/ddr.21660","article-title":"Lithium treatment in the era of personalized medicine","volume":"82","author":"Rybakowski","year":"2021","journal-title":"Drug Dev Res"},{"key":"2024091309185971400_ref6","first-page":"e21427","article-title":"Arrhythmia with lithium toxicity requiring urgent dialysis: a case report","volume":"14","author":"Rijal","year":"2022","journal-title":"Cureus"},{"key":"2024091309185971400_ref7","doi-asserted-by":"crossref","first-page":"875","DOI":"10.2215\/CJN.10021014","article-title":"Extracorporeal treatment for lithium poisoning: systematic review and recommendations from the EXTRIP workgroup","volume":"10","author":"Decker","year":"2015","journal-title":"Clin J Am Soc Nephrol"},{"key":"2024091309185971400_ref8","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2169\/internalmedicine.45.1482","article-title":"Cathartic-induced fatal hypermagnesemia in the elderly","volume":"45","author":"Onishi","year":"2006","journal-title":"Intern Med"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2024\/9\/omae107\/59094845\/omae107.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2024\/9\/omae107\/59094845\/omae107.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T19:18:37Z","timestamp":1726255117000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omae107\/7755720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,1]]},"references-count":8,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omae107","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,9]]},"published":{"date-parts":[[2024,9,1]]},"article-number":"omae107"}}