{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:22:36Z","timestamp":1785280956656,"version":"3.55.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Disseminated histoplasmosis is rarely reported in patients living with cancers in Nigeria. We report a 40-year-old woman who presented with left neck swelling and abdominal pain of two weeks duration. Clinical examination and radiological findings showed pallor, epigastric tenderness, generalized lymphadenopathy and hepatosplenomegaly. An initial diagnosis of sepsis and micronutrient deficiency was made following findings of macrocytosis, hypersegmented neutrophils and toxic granulations on blood smear. Intervention with antibiotics did not improve symptoms rather her clinical presentation worsened with the onset of fever, dizziness, easy fatiguability and generalized weakness. Histology of lymph node biopsy reported a diffuse large B-cell lymphoma. A repeat examination of the blood smear revealed budding yeast cells morphologically similar to Histoplasma capsulatum. This case emphasizes the need for a high index of suspicion of histoplasmosis in this at-risk population and the usefulness of a blood smear in diagnosing histoplasmosis.<\/jats:p>","DOI":"10.1093\/omcr\/omae116","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T14:04:54Z","timestamp":1728569094000},"source":"Crossref","is-referenced-by-count":2,"title":["Disseminated histoplasmosis diagnosed on a blood smear in a Nigerian patient with non-Hodgkin\u2019s lymphoma"],"prefix":"10.1093","volume":"2024","author":[{"given":"Ofonime O","family":"Benjamin","sequence":"first","affiliation":[{"name":"University of Calabar Teaching Hospital Department of Haematology and Blood Transfusion, , Calabar, 540242,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omolabake E","family":"Riman","sequence":"additional","affiliation":[{"name":"University of Calabar Teaching Hospital Department of Haematology and Blood Transfusion, , Calabar, 540242,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Offiong","sequence":"additional","affiliation":[{"name":"University of Calabar Teaching Hospital Department of Medical Microbiology and Parasitology, , Calabar, 540242,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter O","family":"Egbara","sequence":"additional","affiliation":[{"name":"University of Calabar Teaching Hospital Department of Internal Medicine, , Calabar, 540242,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asukwo","family":"Onukak","sequence":"additional","affiliation":[{"name":"University of Uyo Department of Internal Medicine, , Uyo, 520001,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aje N","family":"Ogar","sequence":"additional","affiliation":[{"name":"University of Calabar Teaching Hospital Department of Haematology and Blood Transfusion, , Calabar, 540242,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0509-2480","authenticated-orcid":false,"given":"Bassey E","family":"Ekeng","sequence":"additional","affiliation":[{"name":"University of Calabar Teaching Hospital Department of Medical Microbiology and Parasitology, , Calabar, 540242,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"2024101013344020500_ref1","doi-asserted-by":"publisher","first-page":"e0006046","DOI":"10.1371\/journal.pntd.0006046","article-title":"Histoplasmosis in Africa: an emerging or a neglected disease?","volume":"12","author":"Oladele Oladele","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"key":"2024101013344020500_ref2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.4103\/npmj.npmj_311_22","article-title":"Current epidemiology of 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with presumptive pulmonary tuberculosis in Calabar, Nigeria","volume":"9","author":"Ekeng","year":"2022","journal-title":"Open Forum Infect Dis"},{"key":"2024101013344020500_ref6","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.3201\/eid2811.220542","article-title":"Prevalence of histoplasmosis among persons with advanced HIV disease, Nigeria","volume":"28","author":"Oladele","year":"2022","journal-title":"Emerg Infect Dis"},{"key":"2024101013344020500_ref7","doi-asserted-by":"publisher","first-page":"94","DOI":"10.4103\/npmj.npmj_19_19","article-title":"Mycology-related dissertations from the faculty of pathology, national postgraduate medical college of Nigeria (1980-2017): output and scientific communication","volume":"26","author":"Osaigbovo","year":"2019","journal-title":"Niger Postgrad Med J"},{"key":"2024101013344020500_ref8","doi-asserted-by":"publisher","first-page":"20499361211008675","DOI":"10.1177\/20499361211008675","article-title":"Histoplasmosis overlapping 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