{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:32:04Z","timestamp":1792067524076,"version":"4.4.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Enteric fever is one of the important causes of tropical fever with a prevalence of 11\u201321 million cases worldwide annually. It encompasses both typhoid and paratyphoid fever. Salmonella enterica Typhi is the causative organism for typhoid fever, manifesting as an uncomplicated febrile illness to life-threatening sepsis with multiorgan dysfunction. It is complicated by neuropsychiatric manifestation (2%\u201340%), gastrointestinal bleeding (10%), and intestinal perforation (1%\u20133%). Hemophagocytic Lymphohistiocytosis (HLH) is a rare complication of typhoid fever. Herein we report the case of a 24-year-old male from North-Eastern India, presenting with spikes of fever, altered behavior, a generalized rash, haematochezia, and hemophagocytes on bone marrow examination due to hemophagocytic lymphohistiocytosis secondary to complicated typhoid fever.<\/jats:p>","DOI":"10.1093\/omcr\/omae151","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T02:13:01Z","timestamp":1733883181000},"source":"Crossref","is-referenced-by-count":2,"title":["A rare case of complicated typhoid fever presenting with secondary Hemophagocytic Lymphohistiocytosis"],"prefix":"10.1093","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8988-5092","authenticated-orcid":false,"given":"Mir Wasim","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, IPGMER & SSKM Hospital , 242 Harish Mukherjee Road, Kolkata 700020,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumadip","family":"Rakshit","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, IPGMER & SSKM Hospital , 242 Harish Mukherjee Road, Kolkata 700020,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atreyee","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Department of Pathology, IPGMER & SSKM Hospital , 242 Harish Mukherjee Road, Kolkata 700020,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Karimulla","family":"Mondal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, IPGMER & SSKM Hospital , 242 Harish Mukherjee Road, Kolkata 700020,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anup Kumar","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, IPGMER & SSKM Hospital , 242 Harish Mukherjee Road, Kolkata 700020,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uttara","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Pathology, IPGMER & SSKM Hospital , 242 Harish Mukherjee Road, Kolkata 700020,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"2024121101375528500_ref1","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.5045\/br.2021.2020323","article-title":"Current status of the diagnosis and treatment of hemophagocytic lymphohistiocytosis in adults","volume":"56","author":"Kim","year":"2021","journal-title":"Blood Res"},{"key":"2024121101375528500_ref2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1093\/tropej\/48.2.102","article-title":"Complications of bacteriologically confirmed typhoid fever in children","volume":"48","author":"Malik","year":"2002","journal-title":"J Trop Pediatr"},{"key":"2024121101375528500_ref3","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2471\/BLT.06.039818","article-title":"A study of typhoid fever in five Asian countries: disease burden and implications for controls","volume":"86","author":"Ochiai","year":"2008","journal-title":"Bull World Health Organ"},{"key":"2024121101375528500_ref4","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.18203\/2349-3291.ijcp20171730","article-title":"A study on clinical profile of typhoid fever in children","volume":"4","author":"Devaranavadagi","year":"2017","journal-title":"Int J Contemp Pediatr"},{"key":"2024121101375528500_ref5","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S1473-3099(07)70290-6","article-title":"Infections associated with haemophagocytic syndrome","volume":"7","author":"Rouphael","year":"2007","journal-title":"Lancet"},{"key":"2024121101375528500_ref6","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1365-2257.2005.00717.x","article-title":"Infection-associated haemophagocytosis: the tropical spectrum","volume":"27","author":"Singh","year":"2005","journal-title":"Clin Lab Haematol"},{"key":"2024121101375528500_ref7","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/ped.13064","article-title":"Hemophagocytic lymphohistiocytosis: pathogenesis, diagnosis, and management","volume":"58","author":"Morimoto","year":"2016","journal-title":"Pediatr Int"},{"key":"2024121101375528500_ref8","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0736-4679(03)00212-9","article-title":"A case of typhoid fever associated with hemophagocytic syndrome","volume":"25","author":"\u00c7aksen","year":"2003","journal-title":"J Emerg Med"},{"key":"2024121101375528500_ref9","first-page":"54","article-title":"Infections and HLH - experience from a tertiary care center","volume":"67","author":"Ray","year":"2019","journal-title":"J Assoc Physicians India"},{"key":"2024121101375528500_ref10","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/(SICI)1096-911X(199705)28:5<342::AID-MPO3>3.0.CO;2-H","article-title":"HLH-94: a treatment protocol for hemophagocytic lymphohistiocytosis. HLH study Group of the Histiocyte Society","volume":"28","author":"Henter","year":"1997","journal-title":"Med Pediatr Oncol"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2024\/12\/omae151\/61015757\/omae151.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2024\/12\/omae151\/61015757\/omae151.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T02:13:06Z","timestamp":1733883186000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omae151\/7919851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":10,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12,10]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omae151","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,12]]},"published":{"date-parts":[[2024,12]]},"article-number":"omae151"}}