{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:04:22Z","timestamp":1753877062675,"version":"3.41.2"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:00:00Z","timestamp":1740182400000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Castleman\u2019s Disease is an idiopathic rare lymphoproliferative disorder that is clinically Classified to multicentric to unicentric types. Only few cases were reported in children, with majority of them are unicentric and usually located in the mediastinum. We report a unique case of a 13-year-old boy who presented with a palpable enlarged mass in the left inguinal region without any constitutional symptoms. Surgical removal of this mass was essential to exclude worrying causes. Pathologic examination revealed proliferative changes consistent with Castleman\u2019s disease plasma cell type which is one of the rarest forms of the disease in children. To our knowledge, this case is the first reported case of Unicentric Castleman Disease (UCD) in the inguinal area. During a 12-month-period of follow-up, no additional lymph node enlargements or other symptoms were reported. In conclusion, any isolated lymph node enlargement wherever it is, especially in a child, should impose UCD as a possible differential diagnosis.<\/jats:p>","DOI":"10.1093\/omcr\/omae181","type":"journal-article","created":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T06:26:06Z","timestamp":1740205566000},"source":"Crossref","is-referenced-by-count":0,"title":["Challenging diagnosis: unusual presentation of Unicentric Castleman disease\u2014a case report"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4630-8393","authenticated-orcid":false,"given":"Omran Khaled","family":"Janoud","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Damascus University , Damascus ,","place":["Syria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raya Ehsan","family":"Alok","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Damascus University , Damascus ,","place":["Syria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khozama Ali","family":"Amer","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Damascus University , Damascus ,","place":["Syria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rana Mohammad","family":"Awwad","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Damascus University , Damascus ,","place":["Syria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wessam","family":"Souliman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Damascus University , Damascus ,","place":["Syria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghuroub","family":"Alkhayer","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Damascus University , Damascus ,","place":["Syria"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,2,22]]},"reference":[{"key":"2025022206260009300_ref1","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.ijporl.2016.04.031","article-title":"Castleman\u2019s disease: an unusually young presentation resulting in delayed diagnosis of a neck mass","volume":"86","author":"Linkhorn","year":"2016","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"2025022206260009300_ref2","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/s41572-021-00317-7","article-title":"Castleman disease","volume":"7","author":"Carbone","year":"2021","journal-title":"Nat Rev Dis Primer"},{"key":"2025022206260009300_ref3","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1182\/blood.2019000931","article-title":"Overview of Castleman 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report","volume":"10","author":"Zhai","year":"2022","journal-title":"World J Clin Cases"},{"key":"2025022206260009300_ref8","doi-asserted-by":"publisher","first-page":"1057683","DOI":"10.3389\/fonc.2023.1057683","article-title":"Unicentric form of Castleman\u2019s disease, pitfalls of diagnosis and surgical treatment","volume":"13","author":"Molacek","year":"2023","journal-title":"Front Oncol"},{"key":"2025022206260009300_ref9","doi-asserted-by":"publisher","first-page":"01455613231214643","DOI":"10.1177\/01455613231214643","article-title":"Castleman disease of the Parapharyngeal space in a Pediatric patient: a case report","author":"Wang","year":"2023","journal-title":"Ear Nose Throat J"},{"key":"2025022206260009300_ref10","doi-asserted-by":"publisher","first-page":"e8258","DOI":"10.1002\/ccr3.8258","article-title":"Unicentric Castleman disease presenting as a longstanding axillary and chest wall mass: a case report","volume":"11","author":"Zhou","year":"2023","journal-title":"Clin Case Rep"},{"key":"2025022206260009300_ref11","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.21037\/atm-22-4461","article-title":"Intestinal pseudo-obstruction in systemic lupus erythematosus complicated by Castleman disease: a case report","volume":"10","author":"Lan","year":"2022","journal-title":"Ann Transl Med"},{"key":"2025022206260009300_ref12","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1097\/MPH.0000000000001557","article-title":"Unicentric Castleman disease mimicking an autoinflammatory disorder: a diagnostic challenge in a Pediatric patient with recurrent fever","volume":"42","author":"Kisla Ekinci","year":"2020","journal-title":"J Pediatr Hematol Oncol"},{"key":"2025022206260009300_ref13","doi-asserted-by":"publisher","first-page":"e27613","DOI":"10.1002\/pbc.27613","article-title":"Castleman disease in pediatrics: insights on presentation, treatment, and outcomes from a two-site retrospective cohort 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