{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:10:48Z","timestamp":1770883848634,"version":"3.50.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Leishmaniasis is caused by an intracellular parasite transmitted to humans by the bite of a sandfly: Phlebotomus. The disease can present in three ways: visceral, cutaneous, or mucocutaneous forms. Unusual clinical presentations of cutaneous leishmaniasis have been reported: psoriasiform, eczematiform, erysipeloid, and sporotrichoid, depending on host immune status and Leishmania subspecies. We report a case of an unusual presentation of erysipeloid cutaneous leishmaniasis treated with the combination of Metronidazole and Clarithromycin. A 67-year-old woman presented with a 2-month history of swelling of the centrofacial region, with an erythematous and edematous plaque; the episode was treated as facial erysipelas with antibiotics. In the absence of improvement, the diagnosis of cutaneous leishmaniasis in its erysipeloid form was suspected and then confirmed by a skin smear showing the presence of leishmania amastigotes. The patient was treated with metronidazole and clarithromycin for 30\u00a0days, with good progression.<\/jats:p>","DOI":"10.1093\/omcr\/omae194","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:19:52Z","timestamp":1742516392000},"source":"Crossref","is-referenced-by-count":2,"title":["Erysipeloid cutaneous Leishmaniasis treated with the combination of metronidazole and clarithromycin"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5690-2436","authenticated-orcid":false,"given":"Meryem","family":"Khallouki","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine and Pharmacy, Mohammed VI University Hospital 53 Ibn Sina Street, Cadi Ayad University , Marrakech 40000 ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaoula","family":"Jaatar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine and Pharmacy, Mohammed VI University Hospital 53 Ibn Sina Street, Cadi Ayad University , Marrakech 40000 ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3592-6423","authenticated-orcid":false,"given":"Layla","family":"Bendaoud","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine and Pharmacy, Mohammed VI University Hospital 53 Ibn Sina Street, Cadi Ayad University , Marrakech 40000 ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6142-8970","authenticated-orcid":false,"given":"Mariem","family":"Aboudourib","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine and Pharmacy, Mohammed VI University Hospital 53 Ibn Sina Street, Cadi Ayad University , Marrakech 40000 ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Said","family":"Amal","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine and Pharmacy, Mohammed VI University Hospital 53 Ibn Sina Street, Cadi Ayad University , Marrakech 40000 ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ouafa","family":"Hocar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine and Pharmacy, Mohammed VI University Hospital 53 Ibn Sina Street, Cadi Ayad University , Marrakech 40000 ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"2025032016290556600_ref1","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1007\/s40257-022-00726-8","article-title":"Cutaneous Leishmaniasis: a 2022 updated narrative review into diagnosis and management developments","volume":"23","author":"De Vries","year":"2022","journal-title":"Am J Clin Dermatol"},{"key":"2025032016290556600_ref2","first-page":"391","article-title":"Cutaneous erysipeloid leishmaniasis: an unusual presentation","volume":"9","author":"Jihane","year":"2019","journal-title":"J Clin Trials"},{"key":"2025032016290556600_ref3","first-page":"36","article-title":"Clinical polymorphism of cutaneous leishmaniasis in Centre and south of Tunisia","volume":"100","author":"Masmoudi","year":"2007","journal-title":"Bull Soc Pathol Exot"},{"key":"2025032016290556600_ref4","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1111\/ijd.16278","article-title":"Erysipeloid cutaneous leishmaniasis: a study of 40 cases of an unusual variant","volume":"61","author":"Kouki","year":"2022","journal-title":"Int J Dermatol"},{"key":"2025032016290556600_ref5","doi-asserted-by":"publisher","first-page":"A58","DOI":"10.1016\/j.annder.2019.09.033","article-title":"L\u2019association m\u00e9tronidazole-clarithromycine Est Une alternative th\u00e9rapeutique int\u00e9ressante dans la leishmaniose cutan\u00e9e","volume":"146","author":"Belhareth","year":"2019","journal-title":"Ann Dermatol Venereol"},{"key":"2025032016290556600_ref6","doi-asserted-by":"publisher","first-page":"91","DOI":"10.22038\/rcm.2019.42632.1287","article-title":"Systemic treatments of Leishmaniasis: a narrative review","volume":"6","author":"Taheri","year":"2019","journal-title":"Reviews in Clinical Medicine"},{"key":"2025032016290556600_ref7","doi-asserted-by":"publisher","first-page":"967","DOI":"10.2741\/4629","article-title":"Leishmaniasis treatment: update of possibilities for drug repurposing","volume":"23","author":"Andrade-Neto","year":"2018","journal-title":"Front Biosci (Landmark Ed)"},{"key":"2025032016290556600_ref8","first-page":"1210","article-title":"Antileishmanial activity of liposomal clarithromycin against Leishmania major promastigotes","volume":"15","author":"Sazgarnia","year":"2012","journal-title":"Iran J Basic Med Sci"}],"container-title":["Oxford Medical Case 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