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He presented with intermittent epigastric pain and elevated pancreatic enzymes. MRCP and endoscopic ultrasound revealed an oval lesion near the pancreatic head, confirmed as a grade 1 neuroendocrine tumor on biopsy. A Whipple procedure was performed based on tumor size and location. This case highlights the rare occurrence of pNET presenting with acute pancreatitis.<\/jats:p>","DOI":"10.1093\/omcr\/omae207","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T10:26:47Z","timestamp":1747304807000},"source":"Crossref","is-referenced-by-count":0,"title":["Non-functioning pancreatic neuroendocrine tumor presenting with acute pancreatitis: a case report"],"prefix":"10.1093","volume":"2025","author":[{"given":"Aref","family":"Al-Rajabi","sequence":"first","affiliation":[{"name":"Assistant Professor , , West Bank, Hebron P700 ,","place":["Palestine"]},{"name":"Palestine Polytechnic University; Al Ahli Hospital, Gastroenterology , , West Bank, Hebron P700 ,","place":["Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4684-8102","authenticated-orcid":false,"given":"Amal A","family":"Thweib","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Sciences, Palestine Polytechnic University , West Bank, Bethlehem P150 ,","place":["Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2845-3222","authenticated-orcid":false,"given":"Natalia M","family":"Daghlis","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Sciences, Palestine Polytechnic University , West Bank, Salfeet P390 ,","place":["Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6986-7431","authenticated-orcid":false,"given":"Howaida A","family":"Rabba","sequence":"additional","affiliation":[{"name":"Collage of Medicine and Health Sciences, Palestine Polytechnic University , West Bank, Hebron P700 ,","place":["Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nameer","family":"AbuMunshar","sequence":"additional","affiliation":[{"name":"Collage of Medicine and Health Sciences, Palestine Polytechnic University , West Bank, Hebron P700 ,","place":["Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdel Majeed","family":"Al Ali","sequence":"additional","affiliation":[{"name":"Gastroenterology, Al Ahli Hospital; Najah National University Hospital, Nablus , West Bank, Hebron P700 ,","place":["Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izzeddin A","family":"Bakri","sequence":"additional","affiliation":[{"name":"Pathology Department, Al Ahli Hospital, West Bank, Hebron P700 \u00a0","place":["Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"2025052712115599000_ref1","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1093\/oncolo\/oyac049","article-title":"Survival and incidence patterns of pancreatic neuroendocrine tumors over the last 2 decades: a seer database analysis","volume":"27","author":"Sonbol","year":"2022","journal-title":"Oncologist"},{"key":"2025052712115599000_ref2","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.3390\/cancers14051119","volume-title":"Update on epidemiology, diagnosis, and biomarkers in gastroenteropancreatic neuroendocrine neoplasms","author":"Takayanagi","year":"2022"},{"key":"2025052712115599000_ref3","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1007\/s40618-022-01985-2","article-title":"The incidence, prevalence, and survival analysis of pancreatic neuroendocrine tumors in the United States","volume":"46","author":"Liu","year":"2023","journal-title":"J Invest"},{"key":"2025052712115599000_ref4","first-page":"56","article-title":"Acute pancreatitis associated with neuroendocrine tumor of the pancreas","volume":"7","author":"Jukemura","year":"2006","journal-title":"JOP J Pancreas (Online)"},{"key":"2025052712115599000_ref5","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.3748\/wjg.v26.i19.2305","article-title":"Pancreatic neuroendocrine tumors: a review of serum biomarkers, staging, and management","volume":"26","author":"Ma","year":"2020","journal-title":"World J Gastroenterol"},{"key":"2025052712115599000_ref6","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1111\/his.13975","article-title":"The 2019 WHO classification of tumours of the digestive system","volume":"76","author":"Nagtegaal Iris","year":"2020","journal-title":"Histopathology"},{"key":"2025052712115599000_ref7","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1159\/000055803","article-title":"Co-existent chronic pancreatitis and pancreatic neuroendocrine tumor","volume":"1","author":"Shrikhandea","year":"2001","journal-title":"Pancreatology"},{"key":"2025052712115599000_ref8","article-title":"Acute pancreatitis secondary to non-functioning pancreatic neuroendocrine tumor: uncommon clinical presentation. 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