{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T09:41:45Z","timestamp":1784886105953,"version":"3.55.0"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Bowen's disease (BD) is the second most common skin cancer worldwide, often linked to sun exposure, arsenic, and immunosuppression. Though rare in pediatrics, it is the third most common pediatric skin cancer, associated with conditions like albinism and immunosuppression. Recent years have seen an increase in Squamous Cell Carcinoma (SCC) cases among children, potentially related to immunosuppression and human papillomavirus (HPV) infection, particularly subtype 16. We present the case of an 11-year-old girl from Mexico City with a five-year history of a slowly growing, asymptomatic, dark-brown plaque on the periungual region of her right hand. Histopathological examination revealed Pigmented Squamous Cell Carcinoma in situ. The lesion was treated with excision, nail apparatus removal, and adjuvant 5% imiquimod cream, followed by skin grafting. This case underscores the importance of considering malignancy in pediatric patients, particularly with atypical presentations in acral sites, and highlights the diagnostic challenges of pigmented SCC.<\/jats:p>","DOI":"10.1093\/omcr\/omae216","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T16:40:35Z","timestamp":1743439235000},"source":"Crossref","is-referenced-by-count":1,"title":["Periungual squamous cell carcinoma in childhood: a case report"],"prefix":"10.1093","volume":"2025","author":[{"given":"Marysol","family":"Macedo-P\u00e9rez","sequence":"first","affiliation":[{"name":"Department of Dermatology, Hospital General Dr. Manuel Gea Gonzalez , Calz. de Tlalpan 4800, Belisario Dom\u00ednguez Secc 16, Tlalpan, Ciudad de Mexico 14080 ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Arroyo-Camarena","sequence":"additional","affiliation":[{"name":"Cl\u00ednica de Oncodermatolog\u00eda, Facultad de Medicina , Dr. Balmis 148, Doctores, Coyoac\u00e1n, Ciudad de M\u00e9xico 06720 ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Rold\u00e1n-Mar\u00edn","sequence":"additional","affiliation":[{"name":"Cl\u00ednica de Oncodermatolog\u00eda, Facultad de Medicina , Dr. Balmis 148, Doctores, Coyoac\u00e1n, Ciudad de M\u00e9xico 06720 ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Toussaint-Caire","sequence":"additional","affiliation":[{"name":"Department of Dermatopathology, Hospital General Dr. Manuel Gea Gonzalez , Calz. de Tlalpan 4800, Belisario Dom\u00ednguez Secc 16, Tlalpan, Ciudad de Mexico 14080 ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2719-1105","authenticated-orcid":false,"given":"Froylan D","family":"Mart\u00ednez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital General Dr. Manuel Gea Gonzalez , Calz. de Tlalpan 4800, Belisario Dom\u00ednguez Secc 16, Tlalpan, Ciudad de Mexico 14080 ,","place":["Mexico"]},{"name":"Facultad de Medicina, Universidad Nacional Autonoma de Mexico . Escolar 411A, Copilco Universidad, Coyoac\u00e1n 04360 Ciudad de M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"2025042806361388100_ref1","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1111\/bjd.15324","article-title":"Cutaneous squamous cell carcinoma: an epidemiological review","volume":"177","author":"Green","year":"2017","journal-title":"Br J Dermatol"},{"key":"2025042806361388100_ref2","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1111\/jdv.13654","article-title":"Bowen disease of the nail unit: a retrospective study of 12 cases and their association with human papillomaviruses","volume":"30","author":"Perruchoud","year":"2016","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2025042806361388100_ref3","doi-asserted-by":"publisher","first-page":"e194","DOI":"10.1016\/j.bjps.2009.03.008","article-title":"Cutaneous squamous cell carcinoma in a child","volume":"62","author":"Kotwal","year":"2009","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"2025042806361388100_ref4","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1097\/00008390-200308000-00013","article-title":"Skin cancer in children and young adults: 28 years' experience from the northern region young Person's malignant disease registry, UK","volume":"13","author":"Pearce","year":"2003","journal-title":"Melanoma Res"},{"key":"2025042806361388100_ref5","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1002\/pbc.24639","article-title":"Trends in incidence of primary cutaneous malignancies in children, adolescents, and young adults: a population-based study","volume":"61","author":"Senerchia","year":"2014","journal-title":"Pediatr Blood Cancer"},{"key":"2025042806361388100_ref6","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1016\/j.jpedsurg.2007.08.025","article-title":"Squamous cell carcinomas in children and young adults: a new wave of a very rare tumor?","volume":"42","author":"Chow","year":"2007","journal-title":"J Pediatr Surg"},{"key":"2025042806361388100_ref7","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/j.jaad.2010.02.057","article-title":"Ungual and periungual human papillomavirus-associated squamous cell carcinoma: a review","volume":"64","author":"Riddel","year":"2011","journal-title":"J Am Acad Dermatol"},{"key":"2025042806361388100_ref8","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.jhsa.2018.12.015","article-title":"Subungual Tumors: an algorithmic approach","volume":"44","author":"Hinchcliff","year":"2019","journal-title":"J Hand Surg Am"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2025\/4\/omae216\/62791138\/omae216.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2025\/4\/omae216\/62791138\/omae216.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T10:36:23Z","timestamp":1745836583000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omae216\/8098718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,28]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,3,28]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omae216","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,4]]},"published":{"date-parts":[[2025,3,28]]},"article-number":"omae216"}}