{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:04:26Z","timestamp":1753877066612,"version":"3.41.2"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hypothyroidism, once considered a rare adverse effect of anti-tuberculosis (TB) medication, is increasingly observed in patients undergoing second-line therapy for multidrug-resistant tuberculosis (MDR-TB). This study discusses a case involving a 17-year-old female patient who presented to the emergency department with sub-acute intestinal obstruction secondary to pulmonary TB. She underwent an exploratory laparotomy, during which routine investigations revealed elevated thyroid-stimulating hormone (TSH) levels. A week later, a second laparotomy was performed under general anaesthesia. Postoperatively, facial puffiness was noted, prompting a repeat TSH test, which indicated a significant increase from the initial levels. The diagnosis was revised to hypothyroidism potentially related to anti-tuberculosis therapy (ATT). While existing literature predominantly associates hypothyroidism with second-line anti-TB medications in MDR-TB patients, this study suggests a potential link between first-line ATT and hypothyroidism. This finding underscores the importance of monitoring TSH levels in patients on first-line anti-TB drugs.<\/jats:p>","DOI":"10.1093\/omcr\/omaf008","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T16:39:25Z","timestamp":1743439165000},"source":"Crossref","is-referenced-by-count":0,"title":["An unexpected case of hypothyroidism in a young female patient undergoing first-line anti-tuberculosis therapy for pulmonary tuberculosis"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1724-4046","authenticated-orcid":false,"given":"Haroon Ahmed","family":"Khan","sequence":"first","affiliation":[{"name":"Department of General Surgery, Institution: Dr Ruth KM Pfau Civil Hospital , Mission Road, New Labour Colony, Nanakwara, Karachi 74200 ,","place":["Pakistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2260-7984","authenticated-orcid":false,"given":"Uooja","family":"Devi","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Institution: Dr Ruth KM Pfau Civil Hospital , Mission Road, New Labour Colony, Nanakwara, Karachi 74200 ,","place":["Pakistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0457-2185","authenticated-orcid":false,"given":"Muhammad Faheem","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Institution: Dr Ruth KM Pfau Civil Hospital , Mission Road, New Labour Colony, Nanakwara, Karachi 74200 ,","place":["Pakistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8775-7353","authenticated-orcid":false,"given":"Ali","family":"Aamir","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Institution: Dr Ruth KM Pfau Civil Hospital , Mission Road, New Labour Colony, Nanakwara, Karachi 74200 ,","place":["Pakistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"2025042806362241700_ref1","doi-asserted-by":"publisher","first-page":"105","DOI":"10.4236\/jtr.2016.43013","article-title":"Drug-induced hypothyroidism during anti-tuberculosis treatment of multidrug-resistant tuberculosis: notes from the field","volume":"04","author":"Munivenkatappa","year":"2016","journal-title":"J Tuberc Res"},{"key":"2025042806362241700_ref2","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1080\/17446651.2024.2307525","article-title":"Drug-induced hypothyroidism in tuberculosis","volume":"19","author":"Quiroz-Aldave","year":"2024","journal-title":"Expert Rev Endocrinol Metab"},{"key":"2025042806362241700_ref3","doi-asserted-by":"publisher","first-page":"876","DOI":"10.5588\/ijtld.15.0692","article-title":"Hypothyroidism during second-line treatment of multidrug-resistant tuberculosis: a prospective study","volume":"20","author":"Bares","year":"2016","journal-title":"Int J Tuberc Lung Dis"},{"key":"2025042806362241700_ref4","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1111\/imj.14085","article-title":"Hypothyroidism associated with therapy for multi-drug-resistant tuberculosis in Australia","volume":"49","author":"Cheung","year":"2019","journal-title":"Intern Med J"},{"volume-title":"Global Tuberculosis Report, 2014 (Drug-Resistant TB, Surveillance and Response)","year":"2015","author":"World Health Organization","key":"2025042806362241700_ref5"},{"key":"2025042806362241700_ref6","doi-asserted-by":"publisher","first-page":"e0218487","DOI":"10.1371\/journal.pone.0218487","article-title":"Is hypothyroidism rare in multidrug resistance tuberculosis patients on treatment? A systematic review and meta-analysis","volume":"14","author":"Tola","year":"2019","journal-title":"PLoS One"},{"key":"2025042806362241700_ref7","doi-asserted-by":"publisher","first-page":"332878","DOI":"10.1080\/20523211.2024.2332878","article-title":"Frequency, management and impact of adverse events on treatment outcomes in patients with multidrug resistant tuberculosis in Balochistan, Pakistan","volume":"17","author":"Rafique","year":"2024","journal-title":"J Pharm Policy Pract"},{"key":"2025042806362241700_ref8","doi-asserted-by":"publisher","first-page":"282","DOI":"10.4103\/0976-500X.85949","article-title":"Analysis of thyroid function tests in patients of multidrug resistance tuberculosis undergoing treatment","volume":"2","author":"Chhabra","year":"2011","journal-title":"J Pharmacol Pharmacother"},{"key":"2025042806362241700_ref9","doi-asserted-by":"publisher","first-page":"48","DOI":"10.7748\/ns2009.01.23.18.48.c6741","article-title":"Assessment and management of patients with hypothyroidism","volume":"23","author":"Carson","year":"2009","journal-title":"Nurs Stand"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2025\/4\/omaf008\/62791126\/omaf008.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2025\/4\/omaf008\/62791126\/omaf008.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T10:36:51Z","timestamp":1745836611000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omaf008\/8098715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,28]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,3,28]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omaf008","relation":{},"ISSN":["2053-8855"],"issn-type":[{"type":"electronic","value":"2053-8855"}],"subject":[],"published-other":{"date-parts":[[2025,4]]},"published":{"date-parts":[[2025,3,28]]},"article-number":"omaf008"}}