{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:12:14Z","timestamp":1753877534850,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Renal mucinous cystadenoma (RMC) is an exceptionally rare finding with a poorly understood pathogenesis. Links between RMC and other malignancies are not well described, nor are there known associations with familial cancer disorders. We present the first case of RMC associated with Lynch syndrome (LS) and neuroendocrine neoplasm. A 56-year-old woman presented with iron deficiency leading to a diagnosis of a colonic mixed neuroendocrine-non-neuroendocrine carcinoma. After initial surgery, she experienced local recurrences at 6 and 12\u00a0months, treated with resection and adjuvant chemotherapy. Tumours displayed deficient MMR proteins with BRAF positivity, and germline testing confirmed LS. Surveillance subsequently revealed a complex cyst arising from a horseshoe kidney, for which she underwent a partial nephrectomy. Histopathology confirmed this to be renal mucinous cystadenoma arising from the pelvicalyceal system. This case underscores the need for further investigation into RMC pathogenesis and its potential association with LS.<\/jats:p>","DOI":"10.1093\/omcr\/omaf012","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T16:40:07Z","timestamp":1743439207000},"source":"Crossref","is-referenced-by-count":0,"title":["Renal mucinous cystadenoma in the context of lynch syndrome and colonic neuroendocrine neoplasm: a case report"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6014-322X","authenticated-orcid":false,"given":"Ivy","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Royal North Shore Hospital , Reserve Road, St Leonards, 2065, Sydney , New South Wales,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence H","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Urology, Westmead Hospital , Hawkesbury Road, Westmead, 2145, Sydney , New South Wales,","place":["Australia"]},{"name":"University of Sydney , Camperdown, 2050, Sydney , New South Wales,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matt","family":"Wong","sequence":"additional","affiliation":[{"name":"University of Newcastle , University Drive, Callaghan, 2308, New South Wales ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon","family":"di Lernia","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Gosford Private Hospital , Burrabil Avenue, Gosford , 2250, New South Wales,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Maclean","sequence":"additional","affiliation":[{"name":"Anatomical Pathology, Douglass Hanly Moir Pathology , Giffnock Avenue, Macquarie Park, 2113, Sydney New South Wales, \u00a0","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Royal North Shore Hospital , Reserve Road, St Leonards, 2065, Sydney , New South Wales,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Royal North Shore Hospital , Reserve Road, St Leonards, 2065, Sydney , New South Wales,","place":["Australia"]},{"name":"University of Sydney , Camperdown, 2050, Sydney , New South Wales,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anu","family":"Ganapathy","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Royal North Shore Hospital , Reserve Road, St Leonards, 2065, Sydney , New South Wales,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Royal North Shore Hospital , Reserve Road, St Leonards, 2065, Sydney , New South Wales,","place":["Australia"]},{"name":"University of Sydney , Camperdown, 2050, Sydney , New South Wales,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"2025042806363284400_ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12301-021-00203-4","article-title":"Parenchymal mucinous cystadenoma of the kidney: a case report and literature review","volume":"27","author":"Kalantari","year":"2021","journal-title":"Afr J Urol"},{"key":"2025042806363284400_ref2","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.gim.2022.01.014","article-title":"Worldwide prevalence of lynch 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kidney","volume":"12","author":"Akan","year":"2005","journal-title":"Int J Urol"},{"key":"2025042806363284400_ref6","first-page":"954","article-title":"Papillary mucinous cystadenoma of probable renal pelvic origin in a horseshoe kidney","volume":"109","author":"Ross","year":"1985","journal-title":"Arch Pathol Lab Med"},{"key":"2025042806363284400_ref7","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.3748\/wjg.v28.i19.2076","article-title":"Mixed neuroendocrine-non-neuroendocrine neoplasms of the digestive system: a mini-review","volume":"28","author":"Toor","year":"2022","journal-title":"World J Gastroenterol"},{"key":"2025042806363284400_ref8","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/s41416-022-02061-5","article-title":"Dual [68Ga]DOTATATE and [18F]FDG PET\/CT in patients with metastatic gastroenteropancreatic neuroendocrine neoplasms: a multicentre validation of the NETPET score","volume":"128","author":"Chan","year":"2023","journal-title":"Br J Cancer"},{"key":"2025042806363284400_ref9","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s40792-022-01471-0","article-title":"A case of strongly suspected lynch syndrome with colorectal neuroendocrine carcinoma","volume":"8","author":"Kobayashi","year":"2022","journal-title":"Surg Case Rep"},{"key":"2025042806363284400_ref10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1530\/ERC-14-0410","article-title":"Microsatellite unstable gastrointestinal neuroendocrine carcinomas: a new clinicopathologic entity","volume":"22","author":"Sahnane","year":"2015","journal-title":"Endocr Relat Cancer"}],"container-title":["Oxford Medical Case 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