{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T23:17:15Z","timestamp":1773962235803,"version":"3.50.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Gastrointestinal clear cell sarcoma is a rare tumor with neuroectodermal differentiation that affects the gastrointestinal tract and involves gene fusion translocations of EWSR1. These tumors predominantly occur in young adults and often display aggressive behavior, with metastases to lymph nodes and the liver. Histologically, the tumor comprises uniform round cells with round nuclei and pale eosinophilic or clear cytoplasm. It exhibits variable mitotic activity and demonstrates positive immunohistochemical staining for S100 and SOX10, while specific melanocytic markers are negative. Currently, no tailored chemotherapy regimen has been identified for this entity. Due to the limited number of reported cases, effective management strategies remain unclear. Here, we present the case of a young adult patient diagnosed with CCS\/GNET using immunohistochemistry. The diagnosis was confirmed by next-generation sequencing (NGS), which detected the characteristic EWSR1-ATF1 gene fusion, and liver metastases were identified during follow-up.<\/jats:p>","DOI":"10.1093\/omcr\/omaf028","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T14:10:16Z","timestamp":1748441416000},"source":"Crossref","is-referenced-by-count":1,"title":["Gastrointestinal clear cell sarcoma, AKA malignant gastrointestinal Neuroectodermal tumor: an uncommon entity in a young patient presenting with Anemia, Intraabdominal mass and subsequent liver metastasis"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0794-3765","authenticated-orcid":false,"given":"Sara","family":"Salehiazar","sequence":"first","affiliation":[{"name":"Pathology and Laboratory Medicine, Harbor-UCLA Medical Center , 1000 W Carson St, Torrance, California 90502 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sava","family":"Grujic","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, Harbor-UCLA Medical Center , 1000 W Carson St, Torrance, California 90502 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"2025052810101430000_ref1","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s12328-021-01554-9","article-title":"Clinical, pathological, and genetic profile of clear cell sarcoma-like tumour of jejunum: report of a rare aggressive tumour of small bowel","volume":"15","author":"Nachiappan","year":"2021","journal-title":"Clin J Gastroenterol"},{"key":"2025052810101430000_ref2","doi-asserted-by":"publisher","DOI":"10.3348\/jksr.2022.0163","article-title":"Clear cell sarcoma-like tumour of jejunum: report of a rare aggressive tumour of small bowel","volume-title":"J Korean Soc Radiol","author":"Park","year":"2023"},{"key":"2025052810101430000_ref3","doi-asserted-by":"publisher","first-page":"407","DOI":"10.5858\/arpa.2013-0547-RS","article-title":"Clear cell sarcoma-like tumor of the gastrointestinal tract; an evolving entity","volume":"139","author":"Wang","year":"2015","journal-title":"Arch Pathol Lab Med"},{"key":"2025052810101430000_ref4","doi-asserted-by":"publisher","first-page":"90","DOI":"10.4103\/IJPM.IJPM_195_19","article-title":"Clear cell sarcoma like tumor of gastrointestinal tract: experience of three cases and review of literature","volume-title":"Indian J Pathol Microbiol","author":"Sonai","year":"2024"},{"key":"2025052810101430000_ref5","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s12029-018-0069-4","article-title":"Clear cell sarcoma-like tumor of the gastrointestinal tract","volume":"50","author":"Askan","year":"2018","journal-title":"J Gastrointest Canc"},{"key":"2025052810101430000_ref6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40792-020-01028-z","article-title":"A long-term survivor of clear cell sarcoma-like tumor of the gastrointestinal tract with liver metastasis: a case report","volume-title":"Surg Case Rep","author":"Okada","year":"2020"},{"key":"2025052810101430000_ref7","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1177\/106689690501300402","article-title":"Clear cell sarcoma-like tumor with osteoclast-like Giant cells in the small bowel: further evidence for a new tumor entity: 2005","volume":"13","author":"Friedrichs","year":"2005","journal-title":"Int J Surg Pathol"},{"key":"2025052810101430000_ref8","doi-asserted-by":"publisher","first-page":"4690","DOI":"10.21037\/qims-21-186","article-title":"Clinical presentation and imaging characteristics of clear cell sarcoma-like tumour of the gastrointestinal tract with liver metastasis: a case description","volume":"11","author":"Liao","year":"2021","journal-title":"Quant Imaging Med Surg"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2025\/5\/omaf028\/63392080\/omaf028.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2025\/5\/omaf028\/63392080\/omaf028.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T14:10:16Z","timestamp":1748441416000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omaf028\/8152172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5,28]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omaf028","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,5]]},"published":{"date-parts":[[2025,5]]},"article-number":"omaf028"}}