{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:56:56Z","timestamp":1780419416392,"version":"3.54.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Introduction: Hemolytic Uremic Syndrome is characterized by Coombs negative microangiopathic hemolytic anemia, severe thrombocytopenia, and acute kidney injury.<\/jats:p>\n               <jats:p>Case Report: Here, we report a 36-year-old male, a case of alcohol related acute pancreatitis. On day 5, he developed fever and tachycardia. Evaluation revealed thrombocytopenia, hemolytic anemia, and acute kidney injury with low C3, normal C4 &amp; ADAMTS13 activity and positive anti-complement factor H antibody. He was diagnosed as a case of Hemolytic Uremic Syndrome and managed with plasmapheresis, hemodialysis, and Intravenous immunoglobulin. He was administered Rituximab on day 15, considering the refractory nature of the disease. Despite the aggressive management, he succumbed to his illness.<\/jats:p>\n               <jats:p>Conclusion: This case highlights atypical Hemolytic Uremic Syndrome as a rare complication of Acute Pancreatitis. Our patient, despite being diagnosed well in time and managed aggressively, had an unfavourable outcome. This condition should be diagnosed well in time, as it is associated with high mortality.<\/jats:p>","DOI":"10.1093\/omcr\/omaf048","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T14:10:02Z","timestamp":1748441402000},"source":"Crossref","is-referenced-by-count":1,"title":["Hemolytic uremic syndrome in severe acute pancreatitis"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0998-0776","authenticated-orcid":false,"given":"Jayaraj","family":"Hasvi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Military Hospital , Bareilly 243001, Bareilly district ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0748-331X","authenticated-orcid":false,"given":"Inder Preet Singh","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, 167 Military Hospital , Pathankot 145001 , Pathankot district,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7679-9491","authenticated-orcid":false,"given":"Saurabh","family":"Dawra","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Command Hospital Udhampur \u00a0 182101 , Udhampur district,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8008-2047","authenticated-orcid":false,"given":"Amulyajit","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, PGI , Jalandhar 144003 , Jalandhar district,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4031-9246","authenticated-orcid":false,"given":"Siddharth","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, 167 Military Hospital , Pathankot 145001 , Pathankot district,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"2025052810095559000_ref1","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1111\/j.1365-2257.2005.00697.x","article-title":"DIC secondary to acute pancreatitis","volume":"27","author":"MW","year":"2005","journal-title":"Clin Lab Haematol"},{"key":"2025052810095559000_ref2","doi-asserted-by":"publisher","first-page":"936","DOI":"10.3324\/haematol.10963","article-title":"Pancreatitis preceding acute episodes of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: report of five patients with a systematic review of published reports","volume":"92","author":"Swisher","year":"2007","journal-title":"Haematologica"},{"key":"2025052810095559000_ref3","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1093\/ckj\/sfab051","article-title":"Haemolytic uraemic syndrome associated with pancreatitis: report of four cases and review of the literature","volume":"14","author":"Sandino-P\u00e9rez","year":"2021","journal-title":"Clin Kidney J"},{"key":"2025052810095559000_ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s43054-022-00140-z","article-title":"Acute pancreatitis complicated by hemolytic uremic syndrome: a pediatric case. 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