{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:45:06Z","timestamp":1787579106599,"version":"build-2736575974"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Lung cancer with central nervous system metastases are troublesome clinical scenarios. Rare and diagnostically challenging presentations with subtle image findings may delay diagnosis. We report one case with advanced non-small cell lung cancer. A 48-year-old female present with chewing difficulty, diplopia and facial asymmetry. Magnetic resonance imaging of the brain revealed edematous swelling and abnormal enhancement over bilateral masticator muscles, and faint enhancement over origins of cranial nerves near brainstem. Therefore, masticator muscle denervation related to cranial nerve injury was diagnosed. Symptomatic and disease control was achieved after double dose osimertinib which provide novel insights in the treatment of EGFR-mutant lung cancer with cranial nerve involvement. Chewing difficulty is an exceptional clinical presentation in lung cancer and may lead to delayed diagnosis in case of unawareness. In addition, radiological detectable bilateral masticator muscle denervation is rarely seen and has not been published in the field of lung cancer.<\/jats:p>","DOI":"10.1093\/omcr\/omaf055","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T04:57:32Z","timestamp":1751000252000},"source":"Crossref","is-referenced-by-count":1,"title":["CSF dissemination of EGFR-mutant lung cancer present as cranial nerve injury and masticator muscle denervation: a case report and literature review"],"prefix":"10.1093","volume":"2025","author":[{"given":"Cheng-Sheng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Taipei Medical University Hospital , No. 252, Wuxing St, Xinyi District, Taipei City, 110,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin Li-Chun","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Taipei Medical University , No. 250, Wuxing St, Xinyi District, Taipei City, 110,","place":["Taiwan"]},{"name":"Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University , No. 250, Wuxing St, Xinyi District, Taipei City, 110,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long-Sheng","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Taipei Medical University Hospital , No. 252, Wuxing St, Xinyi District, Taipei City, 110,","place":["Taiwan"]},{"name":"Graduate Institute of Biomedical Materials & Tissue Engineering, College of Biomedical Engineering, Taipei Medical University , No. 250, Wuxing St, Xinyi District, Taipei City, 110,","place":["Taiwan"]},{"name":"International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University , No. 250, Wuxing St, Xinyi District, Taipei City, 110,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeng-Fong","family":"Chiou","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Taipei Medical University Hospital , No. 252, Wuxing St, Xinyi District, Taipei City, 110,","place":["Taiwan"]},{"name":"Taipei Cancer Center, Taipei Medical University , No. 250, Wuxing St, Xinyi District, Taipei City, 110,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"2025062806564461500_ref1","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1097\/JTO.0000000000000267","article-title":"EGFR mutations in Asian patients with advanced lung adenocarcinoma","volume":"9","author":"Liam","year":"2014","journal-title":"J Thorac 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