{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:51:00Z","timestamp":1784609460757,"version":"3.55.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background: Anastrozole, an aromatase inhibitor (AI), has been used extensively for the treatment of estrogen receptor-positive breast cancer. Autoimmune hepatitis (AIH) is an extremely rare but serious complication of anastrozole treatment. Case description: We present the case of an 81-year-old female who presented with significantly elevated liver function test (LFTs) results 8\u00a0months after the initiation of anastrozole for early-stage breast cancer. Serological and liver biopsy findings were consistent with AIH. Discontinuation of anastrozole, along with a short course of steroids, resulted in rapid clinical improvement and normalization of both LFTs and autoantibodies. Conclusion: Clinicians should be aware of drug-induced AIH as a rare but life-threatening complication of anastrozole and potentially other aromatase inhibitors.<\/jats:p>","DOI":"10.1093\/omcr\/omaf062","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T14:10:15Z","timestamp":1748441415000},"source":"Crossref","is-referenced-by-count":2,"title":["Anastrozole-induced autoimmune hepatitis: a rare case report and literature review"],"prefix":"10.1093","volume":"2025","author":[{"given":"Shahab","family":"Haghollahi","sequence":"first","affiliation":[{"name":"Department of Medicine, Dartmouth-Hitchcock Medical Center at Dartmouth Geisel School of Medicine , Hanover, NH 03756 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca M","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dartmouth-Hitchcock Medical Center at Dartmouth Geisel School of Medicine , Hanover, NH 03756 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdol Aziz","family":"Ould Ismail","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center at Dartmouth Geisel School of Medicine , Hanover, NH 03756 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center at Dartmouth Geisel School of Medicine , Hanover, NH 03756 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Z","family":"Afzal","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Dartmouth Hitchcock Cancer Center at Dartmouth Geisel School of Medicine , Hanover, NH 03756 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"2025052810100586400_ref1","volume-title":"U.S. Cancer Statistics Female Breast Cancer Stat Bite","author":"Centers for Disease Control and Prevention","year":"2023"},{"key":"2025052810100586400_ref2","first-page":"4","article-title":"Comprehensive side-effect profile of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: long-term safety analysis of the ATAC trial","volume":"146","author":"Buzdar","year":"2007","journal-title":"ACP J Club"},{"key":"2025052810100586400_ref3","volume-title":"LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]","year":"2012"},{"key":"2025052810100586400_ref4","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1007\/s12328-014-0512-4","article-title":"A case of anastrazole-related drug-induced autoimmune 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