{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T22:55:03Z","timestamp":1767480903840,"version":"3.41.2"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Signet ring cell carcinomas (SRCC) are aggressive neoplasms with poor prognoses, commonly found in the stomach, colon, and small intestine. However, their occurrence in the Ampulla of Vater is rare and their origin remains unclear. Among 163 cases of surgically treated ampullary carcinomas, we observed 4 cases (2.4%) of SRCC with jaundice being the primary clinical manifestation, followed by weight loss and abdominal pain. Duodenoscopy played a pivotal role in the diagnosis. Anatomopathological findings are detailed, emphasizing immuno-histological lineage and lymph node involvement. Two cases underwent adjuvant treatment (GemCap and Folfirinox), with follow-up periods ranging from 18 to 64\u00a0months. We review the literature, highlighting the importance of radical surgery, lymph node involvement, and systemic treatment in the survival of these patients.<\/jats:p>","DOI":"10.1093\/omcr\/omaf072","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T04:58:14Z","timestamp":1751000294000},"source":"Crossref","is-referenced-by-count":1,"title":["Signet ring cell carcinoma of the ampulla of Vater: case series"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8077-9648","authenticated-orcid":false,"given":"Christian","family":"Zeta-Arica","sequence":"first","affiliation":[{"name":"Hepatobiliary Surgery Section, Guillermo Almenara Hospital, Essalud , La Victoria - Lima 0051 ,","place":["Peru"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6445-7636","authenticated-orcid":false,"given":"Lucia","family":"Galarreta-Galvez","sequence":"additional","affiliation":[{"name":"General Surgery Service, Jorge Voto Bernales Hospital , Essalud, Santa Anita - Lima 15011,","place":["Peru"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8316-9703","authenticated-orcid":false,"given":"Fernando","family":"Revoredo-Rego","sequence":"additional","affiliation":[{"name":"Pancreatic Surgery Section, Guillermo Almenara Hospital, Essalud , La Victoria - Lima 0051 ,","place":["Peru"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2930-8362","authenticated-orcid":false,"given":"Fritz","family":"Kometter-Barrios","sequence":"additional","affiliation":[{"name":"Pancreatic Surgery Section, Guillermo Almenara Hospital, Essalud , La Victoria - Lima 0051 ,","place":["Peru"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2679-6778","authenticated-orcid":false,"given":"Jose","family":"Arenas-Gamio","sequence":"additional","affiliation":[{"name":"Pathological Anatomy Section, Guillermo Almenara Hospital, Essalud , La Victoria - Lima 0051 ,","place":["Peru"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"2025062806572651300_ref1","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1002\/jso.21374","article-title":"Cancers of the ampulla of vater: demographics, morphology, and survival based on 5,625 cases from the SEER program","volume":"100","author":"Albores-Saavedra","year":"2009","journal-title":"J Surg Oncol"},{"key":"2025062806572651300_ref2","doi-asserted-by":"publisher","first-page":"190","DOI":"10.6092\/1590-8577\/1267","article-title":"Poorly-differentiated signet-ring cell carcinoma of the ampulla of Vater: report of a rare malignancy","volume":"14","author":"Acharya","year":"2013","journal-title":"JOP J Pancreas"},{"key":"2025062806572651300_ref3","first-page":"87","volume-title":"WHO classification of tumours of the digestive system","author":"Albores-Saavedra","year":"2010"},{"key":"2025062806572651300_ref4","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s12029-015-9718-z","article-title":"Signet ring cell carcinoma of the ampulla of Vater with early development of bone metastasis: case report and review of the rare malignancy","volume":"47","author":"Damania","year":"2016","journal-title":"J Gastrointest Canc"},{"key":"2025062806572651300_ref5","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.3892\/ol.2014.2344","article-title":"Signet ring cell carcinoma of the ampulla of Vater: Immunophenotype and differentiation","volume":"8","author":"Wen","year":"2014","journal-title":"Oncol Lett"},{"key":"2025062806572651300_ref6","doi-asserted-by":"publisher","first-page":"753","DOI":"10.6004\/jnccn.2023.0034","article-title":"Ampullary adenocarcinoma, version 1.2023, NCCN clinical practice guidelines in oncology","volume":"21","author":"Chiorean","year":"2023","journal-title":"J Natl Compr Cancer Netw"},{"key":"2025062806572651300_ref7","doi-asserted-by":"publisher","first-page":"235","DOI":"10.15017\/18765","article-title":"Poorly differentiated adenocarcinoma with signet-ring cells of the Vater\u2019s ampulla, without jaundice but with disseminated carcinomatosis","volume":"94","author":"Nabeshima","year":"2003","journal-title":"Fukuoka Igaku Zasshi"},{"key":"2025062806572651300_ref8","doi-asserted-by":"publisher","first-page":"e627","DOI":"10.1200\/JCO.2011.35.2385","article-title":"Signet ring cell carcinoma of the ampulla of Vater with leptomeningeal metastases: a case report","volume":"29","author":"Paplomata","year":"2011","journal-title":"J Clin Oncol"},{"key":"2025062806572651300_ref9","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1016\/j.hpb.2020.03.024","article-title":"Signet ring cell carcinoma of the ampulla of Vater: outcomes of patients in the United States","volume":"22","author":"Kinslow","year":"2020","journal-title":"HPB"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2025\/6\/omaf072\/63596165\/omaf072.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2025\/6\/omaf072\/63596165\/omaf072.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T10:57:36Z","timestamp":1751108256000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omaf072\/8175753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6,27]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omaf072","relation":{},"ISSN":["2053-8855"],"issn-type":[{"type":"electronic","value":"2053-8855"}],"subject":[],"published-other":{"date-parts":[[2025,6]]},"published":{"date-parts":[[2025,6]]},"article-number":"omaf072"}}