{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:52:08Z","timestamp":1754160728714,"version":"3.41.2"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Bartter syndrome is a rare inherited renal tubular disorder characterised by metabolic alkalosis, hyperaldosteronism, and salt wasting due to defective salt reabsorption in the ascending loop of Henle. The disease is dominant in the antenatal and neonatal populations and rare in adults. Only a small number of studies present adult-onset Bartter syndrome. We present a case of an adult with transient paraplegia diagnosed with Bartter syndrome. A 22-year-old man presented with sudden bilateral lower limb weakness and cramps for two days, with no history of diarrhoea, vomiting, diuretics, laxatives, or addiction. Biochemical studies revealed hypokalemia, metabolic alkalosis, raised urinary potassium levels and raised serum renin. The potassium replacement therapy was initially ineffective in improving symptoms. The raised urinary calcium to creatinine ratio and normal serum magnesium level were noted. There was no nephrocalcinosis, unlike previously reported cases.<\/jats:p>","DOI":"10.1093\/omcr\/omaf100","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T14:47:33Z","timestamp":1752504453000},"source":"Crossref","is-referenced-by-count":0,"title":["A case of adult-onset Bartter syndrome with transient paraplegia"],"prefix":"10.1093","volume":"2025","author":[{"given":"Shahzaib","family":"Siddiqui","sequence":"first","affiliation":[{"name":"Internal Medicine, Jinnah Sindh Medical University , Rafiqui H.J, Iqbal Shaheed Rd, Karachi Cantonment, Karachi 75510,","place":["Pakistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shayan Ali","family":"Irfan","sequence":"additional","affiliation":[{"name":"Internal Medicine, Dow University of Health Sciences , Mission Rd, New Labour Colony Nanakwara, Karachi 74200","place":["Pakistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahrukh","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Internal Medicine, Dow University of Health Sciences , Mission Rd, New Labour Colony Nanakwara, Karachi 74200","place":["Pakistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirza Mehmood Ali","family":"Baig","sequence":"additional","affiliation":[{"name":"Internal Medicine, Dow University of Health Sciences , Mission Rd, New Labour Colony Nanakwara, Karachi 74200","place":["Pakistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jawad","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Internal Medicine, Northwest Health Porter, Valparaiso , Indiana, 46383 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jawed","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Department of Communicable Disease Center, Hamad Medical Corporation , Doha ,","place":["Qatar"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"2025072710513888100_ref1","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1681\/ASN.V93516","article-title":"Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis. A new syndrome","volume":"9","author":"Bartter","year":"1998","journal-title":"J Am Soc Nephrol"},{"key":"2025072710513888100_ref2","doi-asserted-by":"publisher","first-page":"291","DOI":"10.2147\/IJNRD.S155397","article-title":"Bartter syndrome: causes, diagnosis, and treatment","volume":"11","author":"Cunha","year":"2018","journal-title":"Int J Nephrol Renovasc Dis"},{"key":"2025072710513888100_ref3","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.pcl.2018.08.010","article-title":"Bartter syndrome and Gitelman syndrome","volume":"66","author":"Fulchiero","year":"2019","journal-title":"Pediatr Clin N Am"},{"key":"2025072710513888100_ref4","first-page":"437","article-title":"Bartter syndrome: an infrequent tubulopathy of prenatal onset","volume":"90","author":"G\u00f3mez de la","year":"2019","journal-title":"Rev Chil Pediatr"},{"key":"2025072710513888100_ref5","doi-asserted-by":"publisher","first-page":"21","DOI":"10.12659\/AJCR.924527","article-title":"Late-onset Bartter syndrome type II due to a homozygous mutation in KCNJ1 gene: a case report and literature review","volume":"21","author":"Elfert","year":"2020","journal-title":"Am J Case Rep"},{"key":"2025072710513888100_ref6","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1002\/ccr3.2180","article-title":"Pseudo-Bartter syndrome in children with cystic fibrosis","volume":"7","author":"Faraji-Goodarzi","year":"2019","journal-title":"Clin Case Rep"},{"key":"2025072710513888100_ref7","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1590\/S1679-45082015RC3013","article-title":"Adult presentation of Bartter syndrome type IV with erythrocytosis","volume":"13","author":"Heilberg","year":"2015","journal-title":"Einstein (Sao Paulo)"},{"key":"2025072710513888100_ref8","first-page":"91","article-title":"Nephrocalcinosis as adult presentation of Bartter syndrome type II","volume":"72","author":"Huang","year":"2014","journal-title":"Neth J Med"},{"key":"2025072710513888100_ref9","first-page":"222","article-title":"pseudo-Bartter syndrome--2 cases","volume":"67","author":"J\u00f3\u017awiak","year":"2010","journal-title":"Przegl Lek"},{"key":"2025072710513888100_ref10","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1007\/s12098-020-03342-8","article-title":"Cystic fibrosis presenting as pseudo-Bartter syndrome: an important diagnosis that is missed!","volume":"87","author":"Mantoo","year":"2020","journal-title":"Indian J Pediatr"},{"key":"2025072710513888100_ref11","doi-asserted-by":"publisher","first-page":"325","DOI":"10.5414\/CN109784","article-title":"Bartter syndrome type III with only a synonymous mutation of the CLCNKB gene","volume":"92","author":"Xue","year":"2019","journal-title":"Clin Nephrol"},{"key":"2025072710513888100_ref12","first-page":"65","article-title":"A case of Bartter's syndrome presenting in adulthood","volume":"14","author":"Yaqub","year":"2020","journal-title":"Iran J Kidney Dis"},{"key":"2025072710513888100_ref13","doi-asserted-by":"publisher","first-page":"146","DOI":"10.5414\/CN107606","article-title":"Hypokalemic paralysis in a middle-aged female with classic Bartter syndrome","volume":"81","author":"Chiang","year":"2014","journal-title":"Clin Nephrol"},{"key":"2025072710513888100_ref14","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s12519-020-00370-4","article-title":"Bartter's syndrome: clinical findings, genetic causes and therapeutic approach","volume":"17","author":"Mrad","year":"2021","journal-title":"World J Pediatr"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2025\/7\/omaf100\/63748827\/omaf100.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2025\/7\/omaf100\/63748827\/omaf100.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T14:51:42Z","timestamp":1753627902000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omaf100\/8200177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7,14]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omaf100","relation":{},"ISSN":["2053-8855"],"issn-type":[{"type":"electronic","value":"2053-8855"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2025,7]]},"article-number":"omaf100"}}