{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:52:09Z","timestamp":1754160729776,"version":"3.41.2"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Catastrophic Antiphospholipid Syndrome (CAPS) is a rare serious form of APS characterized by thrombosis in multiple organs and a cytokine storm. We report a complex case of a 28-year-old female that tested positive for COVID-19 with a medical history of deep vein thrombosis, pulmonary embolus and systemic lupus erythematosus, with underlying APC, complicating her case of CAPS in multiple organs. Computed Tomography (CT) PE reveled extensive pulmonary emboli and an elevated right\/left ventricular ratio (RV\/LV). CT of the abdomen and pelvis showed gastritis, ascites and anasarca, fluid accumulation and small bilateral pleural effusions. Urinalysis showed low levels of albumin, urine protein 4+ g, and hyperlipidemia. Laboratory test indicated that the patient has developed a worsening non oliguric acute kidney injury and renal biopsy revealed necrotizing. This is a complex case that contributes to the understanding of CAPS and highlights the challenges of its diagnosis and management.<\/jats:p>","DOI":"10.1093\/omcr\/omaf102","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T14:47:32Z","timestamp":1752504452000},"source":"Crossref","is-referenced-by-count":0,"title":["Catastrophic antiphospholipid syndrome in a young patient: a case report of severe multi-organ and cardiovascular involvement"],"prefix":"10.1093","volume":"2025","author":[{"given":"Philip","family":"Desamour","sequence":"first","affiliation":[{"name":"Florida international University Herbert Wertheim College of Medicine , Florida ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakhr","family":"Alshwayyat","sequence":"additional","affiliation":[{"name":"Research Associate, King Hussein Cancer Center , Amman ,","place":["Jordan"]},{"name":"Internship, Princess Basma Teaching Hospital , Irbid ,","place":["Jordan"]},{"name":"Applied Science Research Center, Applied Science Private University , Amman ,","place":["Jordan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucila","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Ross University School of Medicine , Florida ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noor","family":"Almasri","sequence":"additional","affiliation":[{"name":"University of Jordan, \u00a0 Amman ,","place":["Jordan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamdah","family":"Hanifa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Kalamoon , Al-Nabk ,","place":["Syria"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"2025072710513826900_ref1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.14412\/1996-7012-2023-3-7-15","article-title":"Catastrophic antiphospholipid syndrome: current aspects of pathogenesis, diagnosis and treatment","volume":"17","author":"Klimenko","year":"2023","journal-title":"Sovremennaya Revmatol"},{"key":"2025072710513826900_ref2","doi-asserted-by":"publisher","first-page":"e41972","DOI":"10.7759\/cureus.41972","article-title":"A rare rheumatologic case of catastrophic antiphospholipid syndrome","volume":"15","author":"Maheshwari","year":"2023","journal-title":"Cureus."},{"key":"2025072710513826900_ref3","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.reumae.2023.04.003","article-title":"Catastrophic antiphospholipid syndrome in Mexico. 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