{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T14:17:39Z","timestamp":1776867459169,"version":"3.51.2"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Epidermodysplasia verruciformis (EV) is a rare genetic skin disorder characterized by increased susceptibility to human papillomavirus infections (HPV) and a high risk of cutaneous carcinomas. We report the case of a 30-year-old female patient presenting with diffuse verrucous lesions, predominantly affecting the extremities, associated with unilateral elephantiasis. The diagnosis was histologically confirmed, revealing vulgar warts consistent with EV. HIV serology was negative, and systemic retinoid therapy was initiated. EV is linked to mutations in the EVER1 and EVER2 genes, predisposing patients to chronic infections with specific HPV types. Close monitoring is crucial to prevent malignant transformation. This case highlights the diagnostic and therapeutic challenges of EV, emphasizing the importance of an appropriate management strategy to control lesions and prevent complications.<\/jats:p>","DOI":"10.1093\/omcr\/omaf104","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T14:47:38Z","timestamp":1752504458000},"source":"Crossref","is-referenced-by-count":2,"title":["A case of classic epidermodysplasia verruciformis associated with elephantiasis: an atypical presentation"],"prefix":"10.1093","volume":"2025","author":[{"given":"Meryeme","family":"Boutaarourt","sequence":"first","affiliation":[{"name":"Department of Dermatology-Venereology, Mohamed VI University Hospital , M3MF+GCG, 90100 , La Nouvelle Ville Ibn Batouta, Tangier,","place":["Morocco"]},{"name":"Faculty of Medicine and Pharmacy , M3MF+GCG, 90100, La Nouvelle Ville Ibn Batouta, Tangier ,","place":["Morocco"]},{"name":"Abdelmalek Essaadi University , 93030, B.P.2117 - Av.9 Avril, M'hanneche II district, Tetouan,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ouiame","family":"El Jouari","sequence":"additional","affiliation":[{"name":"Department of Dermatology-Venereology, Mohamed VI University Hospital , M3MF+GCG, 90100 , La Nouvelle Ville Ibn Batouta, Tangier,","place":["Morocco"]},{"name":"Faculty of Medicine and Pharmacy , M3MF+GCG, 90100, La Nouvelle Ville Ibn Batouta, Tangier ,","place":["Morocco"]},{"name":"Abdelmalek Essaadi University , 93030, B.P.2117 - Av.9 Avril, M'hanneche II district, Tetouan,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salim","family":"Gallouj","sequence":"additional","affiliation":[{"name":"Department of Dermatology-Venereology, Mohamed VI University Hospital , M3MF+GCG, 90100 , La Nouvelle Ville Ibn Batouta, Tangier,","place":["Morocco"]},{"name":"Faculty of Medicine and Pharmacy , M3MF+GCG, 90100, La Nouvelle Ville Ibn Batouta, Tangier ,","place":["Morocco"]},{"name":"Abdelmalek Essaadi University , 93030, B.P.2117 - Av.9 Avril, M'hanneche II district, Tetouan,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"2025072710514130800_ref1","volume-title":"StatPearls [Internet]","author":"Myers","year":"2025"},{"key":"2025072710514130800_ref2","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.smim.2006.07.008","article-title":"Genetics of epidermodysplasia verruciformis: insights into host defense against papillomaviruses","volume":"18","author":"Orth","year":"2006","journal-title":"Semin Immunol"},{"key":"2025072710514130800_ref3","doi-asserted-by":"publisher","first-page":"A222","DOI":"10.1016\/j.fander.2021.09.171","article-title":"Non-classical epidermodysplasia verruciformis associated with Wiskott-Aldrich syndrome","volume":"1","author":"Magdoud","year":"2021","journal-title":"Ann Dermatol Venereol"},{"key":"2025072710514130800_ref4","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1128\/MMBR.00033-08","article-title":"The EVER proteins as a natural barrier against papillomaviruses: a new insight into the pathogenesis of human papillomavirus infections","volume":"73","author":"Lazarczyk","year":"2009","journal-title":"Microbiol Mol Biol Rev"},{"key":"2025072710514130800_ref5","doi-asserted-by":"publisher","first-page":"3239","DOI":"10.1172\/JCI62949","article-title":"Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections","volume":"122","author":"Crequer","year":"2012","journal-title":"J Clin Invest"},{"key":"2025072710514130800_ref6","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.virol.2008.12.006","article-title":"Small DNA tumor viruses: large contributors to biomedical sciences","volume":"384","author":"Howley","year":"2009","journal-title":"Virology."},{"key":"2025072710514130800_ref7","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s00705-004-0398-4","article-title":"UV-B irradiation stimulates the promoter activity of the high-risk, cutaneous human papillomavirus 5 and 8 in primary keratinocytes","volume":"150","author":"Akg\u00fcl","year":"2005","journal-title":"Arch Virol"},{"key":"2025072710514130800_ref8","volume-title":"Lymphatic filariasis: fact sheet","author":"World Health Organization","year":"2023"},{"key":"2025072710514130800_ref9","article-title":"Elephantiasis nostras verrucosa","author":"Aubin","journal-title":"DermNet Case studies"},{"key":"2025072710514130800_ref10","doi-asserted-by":"publisher","first-page":"704","DOI":"10.4103\/idoj.IDOJ_484_18","article-title":"Treatment of elephantiasis Nostras Verrucosa with CO2 laser","volume":"10","author":"Sancho","year":"2019","journal-title":"Indian Dermatol Online J"},{"key":"2025072710514130800_ref11","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1159\/000249578","article-title":"A case of epidermodysplasia verruciformis (Lewandowsky-Lutz, 1922) with skin cancer: histopathology of malignant cutaneous changes","volume":"169","author":"Tanigaki","year":"1984","journal-title":"Dermatologica."},{"key":"2025072710514130800_ref12","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.3389\/fmicb.2018.01222","article-title":"Epidermodysplasia Verruciformis: inborn errors of immunity to human Beta-papillomaviruses","volume":"9","author":"Jong","year":"2018","journal-title":"Front Microbiol"},{"key":"2025072710514130800_ref16","doi-asserted-by":"publisher","first-page":"A319","DOI":"10.1016\/j.fander.2023.09.550","article-title":"Epidermodysplasia verruciformis treated with nonavalent anti-HPV vaccination","volume-title":"Ann Dermatol Venereol - 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