{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T04:57:36Z","timestamp":1785041856687,"version":"3.55.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Budd-Chiari Syndrome (BCS) is a rare vascular disorder caused by hepatic venous outflow obstruction, often due to thrombosis, leading to liver congestion and portal hypertension. Beh\u00e7et\u2019s Disease (BD), a chronic vasculitis, can cause BCS through inflammation-induced thrombosis. We report a 14-year-old male with BD who developed BCS. He initially presented with foot pain, uveitis, and a bilateral rash, later progressing to abdominal distension, jaundice, and hepatic dysfunction. Investigations revealed elevated transaminases and hyperbilirubinemia, with imaging confirming hepatic vein thrombosis. Management included corticosteroids, immunosuppressants, and anticoagulation. Despite treatment, liver function deteriorated, necessitating a transplant, after which he stabilized with significant symptomatic improvement. This case underscores the need for early recognition of BD-related vascular complications, timely intervention to prevent irreversible liver damage, and consideration of liver transplantation in severe BCS. Increased awareness of BD as a potential cause of BCS is crucial for prompt diagnosis and management.<\/jats:p>","DOI":"10.1093\/omcr\/omaf126","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T22:57:12Z","timestamp":1755039432000},"source":"Crossref","is-referenced-by-count":1,"title":["Aggressive management and liver transplantation in Budd-Chiari syndrome secondary to Beh\u00e7et\u2019s disease"],"prefix":"10.1093","volume":"2025","author":[{"given":"Ali","family":"Bani Odah","sequence":"first","affiliation":[{"name":"Department of Medicine, An Najah National University , Nablus , Pox 7,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaid","family":"Sawaftah","sequence":"additional","affiliation":[{"name":"Department of Medicine, An Najah National University , Nablus , Pox 7,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammar","family":"Hassouneh","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hebron Governmental Hospital , Hebron , P606,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameer","family":"Awashra","sequence":"additional","affiliation":[{"name":"Department of Medicine, An Najah National University , Nablus , Pox 7,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Hamdan","sequence":"additional","affiliation":[{"name":"College of Medicine, QU Health, Qatar University , Doha, 2713 ,","place":["Qatar"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fathi","family":"Milhem","sequence":"additional","affiliation":[{"name":"Department of Medicine, An Najah National University , Nablus , Pox 7,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Sawafta","sequence":"additional","affiliation":[{"name":"Department of Medicine, An Najah National University , Nablus , Pox 7,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Sawafta","sequence":"additional","affiliation":[{"name":"Department of Medicine, An Najah National University , Nablus , Pox 7,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jehad","family":"Khamaysa","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tubas Turkish Governmental Hospital , Tubas ,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader","family":"Sarhan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beit Jala Governmental Hospital , Beit Jala ,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazan","family":"Ghannam","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tubas Turkish Governmental Hospital , Tubas ,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"2025082502171712600_ref1","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s13023-014-0153-1","article-title":"Behcet\u2019s disease in budd-chiari syndrome","volume":"9","author":"Desbois","year":"2014","journal-title":"Orphanet J Rare Dis"},{"key":"2025082502171712600_ref2","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1136\/postgradmedj-2015-133402","article-title":"Budd-Chiari syndrome: investigation, treatment and outcomes","volume":"91","author":"Goel","year":"2015","journal-title":"Postgrad Med J"},{"key":"2025082502171712600_ref3","doi-asserted-by":"publisher","first-page":"69","DOI":"10.14712\/23362936.2017.6","article-title":"Budd-Chiari syndrome","volume":"118","author":"Grus","year":"2017","journal-title":"Prague Med Rep"},{"key":"2025082502171712600_ref4","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1097\/00005792-199401000-00003","article-title":"Hepatic outflow obstruction (Budd-Chiari syndrome). Experience with 177 patients and a review of the literature","volume":"73","author":"Dilawari","year":"1994","journal-title":"Medicine (Baltimore)"},{"key":"2025082502171712600_ref5","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1016\/0016-5085(94)90765-X","article-title":"The changing scene of hepatic vein thrombosis: recognition of asymptomatic cases","volume":"106","author":"Hadengue","year":"1994","journal-title":"Gastroenterology."},{"key":"2025082502171712600_ref6","doi-asserted-by":"publisher","first-page":"2050313X241282383","DOI":"10.1177\/2050313X241282383","article-title":"Diagnosing Beh\u00e7et\u2019s disease in the presence of pulmonary a\ufeffrtery aneurysm and systemic symptoms: a case report","volume":"12","author":"Bani Odah","year":"2024","journal-title":"SAGE Open Med Case Rep"},{"key":"2025082502171712600_ref7","doi-asserted-by":"publisher","first-page":"70","DOI":"10.5582\/irdr.2015.01007","article-title":"Cardiac manifestations in Behcet\u2019s disease","volume":"4","author":"Demirelli","year":"2015","journal-title":"Intractable Rare Dis Res"},{"key":"2025082502171712600_ref8","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.jhep.2015.07.040","article-title":"EASL clinical practice guidelines: vascular diseases of the liver","volume":"64","author":"European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu","year":"2016","journal-title":"J Hepatol"},{"key":"2025082502171712600_ref9","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.radcr.2024.09.148","article-title":"Mixed connective tissue disease: a case of aggressive progression and multisystem involvement","volume":"20","author":"Odah","year":"2024","journal-title":"Radiol Case Rep"},{"key":"2025082502171712600_ref10","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.3892\/etm.2018.7130","article-title":"Budd-Chiari syndrome in Behcet\u2019s disease: a report of two cases","volume":"17","author":"Zhou","year":"2018","journal-title":"Exp Ther Med"},{"key":"2025082502171712600_ref11","doi-asserted-by":"publisher","first-page":"24","DOI":"10.5582\/irdr.2014.01031","article-title":"Budd-Chiari syndrome and liver transplantation","volume":"4","author":"Akamatsu","year":"2015","journal-title":"Intractable Rare Dis Res"},{"key":"2025082502171712600_ref12","doi-asserted-by":"publisher","first-page":"6286","DOI":"10.1016\/j.radcr.2024.09.034","article-title":"Spontaneous angiomyolipoma rupture: a case of hemorrhagic shock and urgent embolization","volume":"19","author":"Awashra","year":"2024","journal-title":"Radiol Case Rep"},{"key":"2025082502171712600_ref13","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1002\/lt.21220","article-title":"Twenty years of liver transplantation for Budd-Chiari syndrome: a national registry analysis","volume":"13","author":"Segev","year":"2007","journal-title":"Liver Transpl"},{"key":"2025082502171712600_ref14","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0000000000000932","article-title":"Metabolic dysfunction-associated Steatotic liver disease as a cardiovascular risk factor: focus on atrial fibrillation","author":"Awashra","year":"2025","journal-title":"Cardiol Rev"},{"key":"2025082502171712600_ref15","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1111\/hepr.12676","article-title":"Liver transplantation in Japan: registry by the Japanese liver transplantation society","volume":"46","author":"Umeshita","year":"2016","journal-title":"Hepatol Res"},{"key":"2025082502171712600_ref16","doi-asserted-by":"crossref","first-page":"omae208","DOI":"10.1093\/omcr\/omae208","article-title":"Catastrophic antiphospholipid syndrome presenting with a stroke as a first presentation: case report","volume":"2025","author":"Nouri","year":"2025","journal-title":"Oxf Med Case Rep"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2025\/8\/omaf126\/64002919\/omaf126.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2025\/8\/omaf126\/64002919\/omaf126.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T06:17:22Z","timestamp":1756102642000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omaf126\/8230256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8,11]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omaf126","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,8]]},"published":{"date-parts":[[2025,8]]},"article-number":"omaf126"}}