{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T08:26:48Z","timestamp":1772440008924,"version":"3.50.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Adrenal infarction (AI) is rare condition caused by inadequate blood supply to the adrenal glands, with few reports of its association with essential thrombocythemia (ET). Here, we report a case of bilateral AI as an initial thrombotic complication in a patient with ET. A 69-year-old man presented with right abdominal pain. Abdominal computed tomography (CT) showed diffuse enlargement and poor enhancement of bilateral adrenal glands. He was diagnosed with bilateral AI. Based on positive screening for thrombocytosis and the Janus kinase 2 V617F mutation, he was diagnosed with ET. After low-dose aspirin therapy, he showed no symptom recurrence. The cortisol response in the adrenocorticotropic hormone stimulation test decreased at onset but improved after three months. Furthermore, abdominal CT revealed improvement in bilateral adrenal enlargement and enhancement. In patients presenting with AI, ET should be considered as a potential underlying disease, and early diagnosis and treatment is important to prevent recurrence.<\/jats:p>","DOI":"10.1093\/omcr\/omaf129","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T22:57:16Z","timestamp":1755039436000},"source":"Crossref","is-referenced-by-count":1,"title":["Bilateral adrenal infarction in a patient with essential thrombocythemia: a case report and brief literature review"],"prefix":"10.1093","volume":"2025","author":[{"given":"Yuko","family":"Fujishima","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrinology, Kobe City Medical Center General Hospital , Kobe 650-0047 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Hataya","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Kobe City Medical Center General Hospital , Kobe 650-0047 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanta","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Kobe City Medical Center General Hospital , Kobe 650-0047 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Iwakura","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Kobe City Medical Center General Hospital , Kobe 650-0047 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Kobe City Medical Center General Hospital , Kobe 650-0047 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"2025082502171963300_ref1","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1007\/s00277-002-0500-5","article-title":"Bilateral adrenal swelling as a cause of chest, back, and upper abdominal pain in essential thrombocythemia and polycythemia vera is due to microvascular ischemic thrombosis rather than to hemorrhage","volume":"81","author":"Michiels","year":"2002","journal-title":"Ann Hematol"},{"key":"2025082502171963300_ref2","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1002\/ajh.20477","article-title":"Bilateral adrenal hemorrhage associated with essential thrombocytosis","volume":"81","author":"Pachipala","year":"2006","journal-title":"Am J Hematol"},{"key":"2025082502171963300_ref3","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1097\/MBC.0000000000001196","article-title":"Adrenal insufficiency revealing bilateral adrenal hemorrhage related to JAK2 V617F-positive essential thrombocythemia: about two cases","volume":"34","author":"Gensous","year":"2023","journal-title":"Blood Coagul Fibrinolysis"},{"key":"2025082502171963300_ref4","doi-asserted-by":"publisher","first-page":"106","DOI":"10.11406\/rinketsu.60.106","article-title":"Essential thrombocythemia accompanied by adrenal infarction","volume":"60","author":"Iemura","year":"2019","journal-title":"Rinsho Ketsueki"},{"key":"2025082502171963300_ref5","doi-asserted-by":"publisher","first-page":"419","DOI":"10.2169\/internalmedicine.1947-23","article-title":"Bilateral adrenal infarction that developed in latent essential Thrombocythemia","volume":"63","author":"Hada","year":"2024","journal-title":"Intern Med"},{"key":"2025082502171963300_ref6","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/s41408-018-0054-y","article-title":"The 2016 WHO classification and diagnostic criteria for myeloproliferative neoplasms: document summary and in-depth discussion","volume":"8","author":"Barbui","year":"2018","journal-title":"Blood Cancer J"},{"key":"2025082502171963300_ref7","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/j.1538-7836.2006.01753.x","article-title":"International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)","volume":"4","author":"Miyakis","year":"2006","journal-title":"J Thromb Haemost"},{"key":"2025082502171963300_ref8","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1016\/S0140-6736(05)67785-9","article-title":"Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study","volume":"366","author":"Campbell","year":"2005","journal-title":"Lancet"},{"key":"2025082502171963300_ref9","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1007\/s12185-020-02964-0","article-title":"JSH practical guidelines for Hematological malignancies, 2018: I. 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Chronic myeloid leukemia (CML)\/myeloproliferative neoplasms (MPN)","volume":"112","author":"Shimoda","year":"2020","journal-title":"Int J Hematol"},{"key":"2025082502171963300_ref10","doi-asserted-by":"publisher","first-page":"e334","DOI":"10.4158\/ACCR-2019-0167","article-title":"Evolving adrenal dysfunction after bilateral adrenal infarction: a case report","volume":"5","author":"You","year":"2019","journal-title":"AACE Clin Case Rep"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2025\/8\/omaf129\/64002931\/omaf129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2025\/8\/omaf129\/64002931\/omaf129.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T06:17:22Z","timestamp":1756102642000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omaf129\/8230257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8,11]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omaf129","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,8]]},"published":{"date-parts":[[2025,8]]},"article-number":"omaf129"}}