{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T06:40:02Z","timestamp":1756104002189,"version":"3.44.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Precocious puberty is a rare condition, particularly in boys, characterized by the early development of secondary sexual characteristics. This case report presents a 5-year-old male from rural Guatemala who exhibited signs of accelerated sexual maturation, including Tanner stage IV genitalia, pubic and facial hair, and advanced bone age. After evaluation, the diagnosis was associated with environmental factors such as chronic malnutrition and psychosocial stress, which likely contributed to the premature activation of the hypothalamic\u2013pituitary-gonadal axis. In low-resource settings, factors like poverty, limited access to healthcare, and nutritional deficiencies can significantly impact growth and development, leading to atypical presentations of conditions like precocious puberty. This case highlights the importance of considering environmental factors and social determinants of health when diagnosing and managing puberty, especially in underserved populations.<\/jats:p>","DOI":"10.1093\/omcr\/omaf150","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T11:50:17Z","timestamp":1753271417000},"source":"Crossref","is-referenced-by-count":0,"title":["Precocious puberty in a rural Guatemalan boy: Unraveling the role of malnutrition and psychosocial stress"],"prefix":"10.1093","volume":"2025","author":[{"given":"Andrea","family":"Argueta","sequence":"first","affiliation":[{"name":"Department of research, Universidad Francisco Marroqu\u00edn , Guatemala 01011 ,","place":["Guatemala"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q","family":"Carlos Diaz","sequence":"additional","affiliation":[{"name":"Department of research, Universidad Francisco Marroqu\u00edn , Guatemala 01011 ,","place":["Guatemala"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor Hugo","family":"Argueta","sequence":"additional","affiliation":[{"name":"Department of research, Universidad Francisco Marroqu\u00edn , Guatemala 01011 ,","place":["Guatemala"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7392-4454","authenticated-orcid":false,"given":"Marian","family":"Vasquez","sequence":"additional","affiliation":[{"name":"Department of research, Universidad Francisco Marroqu\u00edn , Guatemala 01011 ,","place":["Guatemala"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"2025082502151707200_ref1","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1093\/humupd\/7.3.292","article-title":"Pathogenesis and epidemiology of precocious puberty. Effects of exogenous oestrogens","volume":"7","author":"Partsch","year":"2001","journal-title":"Hum Reprod Update"},{"volume-title":"StatPearls","year":"2023","author":"Kota","key":"2025082502151707200_ref2"},{"key":"2025082502151707200_ref3","doi-asserted-by":"publisher","first-page":"e47485","DOI":"10.7759\/cureus.47485","article-title":"Precocious puberty: types, pathogenesis and updated management","volume":"15","author":"Alghamdi","year":"2023","journal-title":"Cureus"},{"key":"2025082502151707200_ref4","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1186\/s12887-023-04013-1","article-title":"The effect of environmental factors on precocious puberty in children: a case-control study","volume":"23","author":"Bigambo","year":"2023","journal-title":"BMC Pediatr"},{"key":"2025082502151707200_ref5","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/s0889-8529(05)70108-0","article-title":"Central precocious puberty. An overview of diagnosis, treatment, and outcome","volume":"28","author":"Lee","year":"1999","journal-title":"Endocrinol Metab Clin N Am"},{"key":"2025082502151707200_ref6","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1210\/clinem\/dgad081","article-title":"Approach to the patient: central precocious puberty","volume":"108","author":"Kilberg","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"key":"2025082502151707200_ref7","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.reprotox.2013.03.012","article-title":"What is in our environment that effects puberty?","volume":"44","author":"Fisher","year":"2014","journal-title":"Reprod Toxicol"},{"key":"2025082502151707200_ref8","doi-asserted-by":"publisher","first-page":"2198","DOI":"10.1210\/jc.2013-1024","article-title":"Treatment and outcomes of precocious puberty: an update","volume":"98","author":"Fuqua","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"2025082502151707200_ref9","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.beem.2018.05.008","article-title":"Central precocious puberty: from genetics to treatment","volume":"32","author":"Aguirre","year":"2018","journal-title":"Best Pract Res Clin Endocrinol Metab"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2025\/8\/omaf150\/64116115\/omaf150.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2025\/8\/omaf150\/64116115\/omaf150.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T06:15:25Z","timestamp":1756102525000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omaf150\/8240474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":9,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8,11]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omaf150","relation":{},"ISSN":["2053-8855"],"issn-type":[{"type":"electronic","value":"2053-8855"}],"subject":[],"published-other":{"date-parts":[[2025,8]]},"published":{"date-parts":[[2025,8]]},"article-number":"omaf150"}}