{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T09:10:16Z","timestamp":1759050616830,"version":"3.44.0"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Acquired angioedema (AAE) is a rare, potentially life-threatening condition caused by bradykinin, typically presenting as recurrent, non-pitting facial swelling without urticaria. Unlike hereditary forms, acquired angioedema arises later in life and may be associated with underlying B-cell lymphoproliferative disorders. We report a 62-year-old woman with persistent antihistamine-unresponsive facial angioedema, fatigue, and moderate splenomegaly, which led to further work-up for AAE. Low C4 and C1 inhibitor (C1-INH) was detected, with normal C1q levels. Given the presence of splenomegaly and cytopenia, further evaluation of lymphoproliferative disease was pursued. Bone marrow biopsy confirmed splenic marginal zone lymphoma (SMZL), and rituximab-based chemotherapy resulted in full remission of both lymphoma and angioedema. This case highlights the importance of evaluating elderly patients with unexplained angioedema and organomegaly for hidden lymphoproliferative disease. Treating the underlying disease can resolve symptoms and improve outcomes.<\/jats:p>","DOI":"10.1093\/omcr\/omaf157","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:14:42Z","timestamp":1758312882000},"source":"Crossref","is-referenced-by-count":0,"title":["A hidden clue behind angioedema in an elderly patient"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1672-4743","authenticated-orcid":false,"given":"Okan","family":"Cetin","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University , Istanbul ,","place":["T\u00fcrkiye"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilkim Deniz","family":"Toprak","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology, Istanbul Faculty of Medicine, Istanbul University , Istanbul ,","place":["T\u00fcrkiye"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamze","family":"Kemec","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University , Istanbul ,","place":["T\u00fcrkiye"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simge","family":"Erdem","sequence":"additional","affiliation":[{"name":"Department of Hematology, Istanbul Faculty of Medicine, Istanbul University , Istanbul ,","place":["T\u00fcrkiye"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulcin","family":"Yegen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Istanbul Faculty of Medicine, Istanbul University , Istanbul ,","place":["T\u00fcrkiye"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semra","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology, Istanbul Faculty of Medicine, Istanbul University , Istanbul ,","place":["T\u00fcrkiye"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,9,15]]},"reference":[{"key":"2025092804464624400_ref1","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1159\/000486312","article-title":"Hereditary and acquired angioedema: heterogeneity of pathogenesis and clinical phenotypes","volume":"175","author":"Bova","year":"2018","journal-title":"Int Arch Allergy Immunol"},{"key":"2025092804464624400_ref2","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1111\/bjh.13908","article-title":"High prevalence of splenic marginal zone lymphoma among patients with acquired C1 inhibitor deficiency","volume":"172","author":"Castelli","year":"2016","journal-title":"Br J Haematol"},{"key":"2025092804464624400_ref3","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.anai.2012.10.008","article-title":"International consensus on hereditary and acquired angioedema","volume":"109","author":"Lang","year":"2012","journal-title":"Ann Allergy Asthma Immunol"},{"key":"2025092804464624400_ref4","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.iac.2006.08.002","article-title":"Acquired deficiency of the inhibitor of the first complement component: presentation, diagnosis, course, and conventional management","volume":"26","author":"Zingale","year":"2006","journal-title":"Immunol Allergy Clin N Am"},{"key":"2025092804464624400_ref5","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1710-1492-6-14","article-title":"Acquired angioedema. 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