{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T22:27:17Z","timestamp":1769380037704,"version":"3.49.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tuberous Sclerosis Complex (TSC) is a rare genetic disorder characterized by the development of benign tumors in multiple organs. This report presents an unusual case of early-onset renal cystic disease in a 1-year-old male with TSC, despite the absence of detectable mutations in the TSC1 or TSC2 genes. Postnatal imaging revealed bilateral polycystic kidney disease by 2\u00a0months of age. The patient presented with secondary hypertension and seizures. Neuroimaging confirmed cortical tubers and a subependymal giant cell astrocytoma (SEGA), while echocardiography identified cardiac rhabdomyomas. Despite these clinical findings, genetic testing failed to detect mutations in the TSC1 or TSC2 genes. This case highlights the importance of considering TSC as a potential diagnosis in cases of early-onset renal cystic disease, even in the absence of detectable TSC gene mutations. Additionally, the case emphasizes the risk of severe renal involvement in TSC, necessitating early recognition and management.<\/jats:p>","DOI":"10.1093\/omcr\/omaf187","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T11:53:02Z","timestamp":1755690782000},"source":"Crossref","is-referenced-by-count":0,"title":["A rare early-onset bilateral renal cysts, focal seizures in a 1-year-old male with tuberous sclerosis and No mutation identified"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0763-4662","authenticated-orcid":false,"given":"Dana","family":"Salahat","sequence":"first","affiliation":[{"name":"Medical Student, Department of Clinical Medical Sciences, Faculty of Medicine and Health Sciences, Palestine Polytechnic University , Hebron, P720 ,","place":["Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9010-0129","authenticated-orcid":false,"given":"Ramzi","family":"Mujahed","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine, Palestine Polytechnic University , Hebron, P720 ,","place":["Palestine"]},{"name":"Department of Pediatrics, Hebron Governmental Hospital , Alia hospital street Hebron, P720 ,","place":["Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3832-2319","authenticated-orcid":false,"given":"Mohanad","family":"Jaber","sequence":"additional","affiliation":[{"name":"Head of Clinical Medicine Department, Faculty of Medicine, Palestine Polytechnic University , Hebron, P720 ,","place":["Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1485-3758","authenticated-orcid":false,"given":"Mohammed","family":"Tahayneh","sequence":"additional","affiliation":[{"name":"Head of Basic Medicine Department, Faculty of Medicine, Palestine Polytechnic University , Hebron ,","place":["Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8020-0630","authenticated-orcid":false,"given":"Nisreen","family":"Khalifa","sequence":"additional","affiliation":[{"name":"Medical Student, Department of Clinical Medical Sciences, Faculty of Medicine and Health Sciences, Palestine Polytechnic University , Hebron, P720 ,","place":["Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3252-2128","authenticated-orcid":false,"given":"Qais","family":"Alnjoom","sequence":"additional","affiliation":[{"name":"Medical Student, Department of Clinical Medical Sciences, Faculty of Medicine and Health Sciences, Palestine Polytechnic University , Hebron, P720 ,","place":["Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8556-3084","authenticated-orcid":false,"given":"Rani","family":"Sabra","sequence":"additional","affiliation":[{"name":"Medical Student, Department of Clinical Medical Sciences, Faculty of Medicine and Health Sciences, Palestine Polytechnic University , Hebron, P720 ,","place":["Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8003-1682","authenticated-orcid":false,"given":"Motasem","family":"Doudin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nephrology, Faculty of Medicine, Hebron University , Hebron ,","place":["Palestine"]},{"name":"Head of Pediatric Nephrology Department at PRCS Hospital , Hebron, P720 ,","place":["Palestine"]},{"name":"Pediatric Nephrology Department, Augusta Victoria Hospital , Jerusalem, 97103 ,","place":["Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2495-0665","authenticated-orcid":false,"given":"Raef","family":"Sabra","sequence":"additional","affiliation":[{"name":"Medical Student, Department of Clinical Medical Sciences, Faculty of Medicine and Health Sciences, Palestine Polytechnic University , Hebron, P720 ,","place":["Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2769-3033","authenticated-orcid":false,"given":"Ibraheem","family":"AbuAlrub","sequence":"additional","affiliation":[{"name":"Research and Teaching Assistant, Department of Clinical Medical Sciences, Faculty of Medicine, Palestine Polytechnic University , Hebron, P720 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for tumor recurrence after surgical resection for subependymal giant cell astrocytoma associated with tuberous sclerosis complex","volume":"28","author":"Franz","year":"2013","journal-title":"J Child Neurol"},{"key":"2026012509584047900_ref18","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.pediatrneurol.2013.08.017","article-title":"Subependymal giant cell astrocytoma: diagnosis, screening, and treatment. 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