{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T01:05:13Z","timestamp":1761181513475,"version":"build-2065373602"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Granular cell tumors (GCTs) are rare, mostly benign soft-tissue neoplasms, with only 8% occurring in the gastrointestinal tract, making the colon an uncommon location. We present the case of a 37-year-old Hispanic woman who underwent a screening colonoscopy due to a family history of colon cancer. A submucosal nodule at the appendiceal orifice was resected, and a biopsy revealed a malignant GCT, confirmed by S100-positive staining. The patient underwent a right hemicolectomy, with the resection showing a 2\u00a0mm focus of granular cell tumor with clear margins. Histopathology confirmed malignancy, with additional findings of reactive hyperplasia of mucosa-associated lymphoid tissue and focal ileitis. Although rare in the colon, malignant GCTs carry a high risk of mortality and recurrence. Small lesions (&amp;lt;\u20091\u00a0cm) can be monitored, but larger or malignant ones require surgical resection. Our case emphasizes the importance of early detection and intervention to prevent severe outcomes in malignant GCTs.<\/jats:p>","DOI":"10.1093\/omcr\/omaf190","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T11:40:01Z","timestamp":1755862801000},"source":"Crossref","is-referenced-by-count":0,"title":["\u2018Malignant granular cell tumor of the Appendiceal orifice: a rare case and review of literature\u2019"],"prefix":"10.1093","volume":"2025","author":[{"given":"Omer","family":"Usman","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Texas Tech University Health Sciences Center El Paso, The Hospital of Providence-2000 Transmountain Road , TX 79911 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Waqas","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, MUSC Health Lancaster Medical Center, 800 W Meeting St , SC 29720 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maham","family":"Tariq","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Services Institute of Medical Sciences , Jail Road, Shadman 54000, Lahore ,","place":["Pakistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Usman","family":"Shahbaz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Jinnah Hospital , Usmani Rd, Faisal Town, Lahore 54550 ,","place":["Pakistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa Javed","family":"Warriach","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Services Institute of Medical Sciences , Jail Road, Shadman 54000, Lahore ,","place":["Pakistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Abdul","family":"Basit","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, UHS Wilson Medical Center , Harrison St. Johnson City, NY 13790 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4916-110X","authenticated-orcid":false,"given":"Hassan Shah","family":"Aryani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, S. Tenteshiv Memorial Asain Medical Institute , Kant 725012 ,","place":["Kyrgyzstan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"2025102212550534900_ref1","doi-asserted-by":"publisher","first-page":"77","DOI":"10.4081\/rt.2017.6420","article-title":"Granular cell tumor of cecum: a common tumor in a rare site with diagnostic challenge","volume":"9","author":"Rajagopal","year":"2017","journal-title":"Rare Tumors"},{"key":"2025102212550534900_ref2","doi-asserted-by":"publisher","first-page":"3000605221109369","DOI":"10.1177\/03000605221109369","article-title":"Granular cell tumor of the appendix: a case report and literature review","volume":"50","author":"Lv","year":"2022","journal-title":"J Int Med Res"},{"key":"2025102212550534900_ref3","first-page":"798","article-title":"Granular cell Tumors of the gastrointestinal tract: questions and answers","volume":"5","author":"Radaelli","year":"2009","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"2025102212550534900_ref4","doi-asserted-by":"publisher","first-page":"102828","DOI":"10.1016\/j.critrevonc.2019.102828","article-title":"Granular cell tumor of the breast: a multidisciplinary challenge","volume":"144","author":"Meani","year":"2019","journal-title":"Crit Rev Oncol Hematol"},{"key":"2025102212550534900_ref5","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.jaad.2017.09.062","article-title":"Epidemiology of malignant cutaneous granular cell tumors: a US population-based cohort analysis using the surveillance, epidemiology, and end results (SEER) database","volume":"78","author":"Mirza","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"2025102212550534900_ref6","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1159\/000529170","article-title":"Granular cell tumor of the ascending colon","volume":"17","author":"Dhruv","year":"2023","journal-title":"Case Rep Gastroenterol"},{"key":"2025102212550534900_ref7","doi-asserted-by":"publisher","first-page":"S57","DOI":"10.1093\/ajcp\/aqaa161.124","article-title":"Granular cell tumor confined to the muscularis propria of the appendix: a case report","volume":"154","author":"Allison","year":"2020","journal-title":"Am J Clin Pathol"},{"key":"2025102212550534900_ref8","doi-asserted-by":"publisher","first-page":"e251058","DOI":"10.1136\/bcr-2022-251058","article-title":"Granular cell tumour of the appendix: an unexpected location","volume":"15","author":"Madeira","year":"2022","journal-title":"BMJ Case Rep"},{"key":"2025102212550534900_ref9","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1186\/2193-1801-2-649","article-title":"Granular cell tumor of the appendix: a new case and review of the literature","volume":"2","author":"Roncati","year":"2013","journal-title":"Springerplus."},{"key":"2025102212550534900_ref10","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1007\/s11605-011-1536-4","article-title":"Acute appendicitis secondary to a granular cell tumor of the appendix in a 19-year-old male","volume":"15","author":"Zoccali","year":"2011","journal-title":"J Gastrointest Surg"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2025\/10\/omaf190\/64858039\/omaf190.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2025\/10\/omaf190\/64858039\/omaf190.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T16:55:15Z","timestamp":1761152115000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omaf190\/8297190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10,21]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omaf190","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,10]]},"article-number":"omaf190"}}