{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T14:05:37Z","timestamp":1761746737463,"version":"build-2065373602"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Silver-Russell syndrome (SRS), also known as Russell-Silver syndrome (RSS), is a congenital growth disorder characterized by intrauterine and postnatal growth retardation, craniofacial disproportion, asymmetry, and other distinctive features. It was first described by Alex Russell and Henry Silver in the 50s of the 20th century. Its broad range of manifestations makes its true incidence difficult to determine. While gastrointestinal anomalies such as gastroesophageal reflux disease and esophagitis have been reported in SRS patients, an association with colorectal cancer (CRC) has not been described. Here, we present the case of a 31-year-old man with SRS who was referred to us for constipation. A rectal biopsy revealed moderately differentiated adenocarcinoma, and a staging CT scan demonstrated multiple lung and hepatic nodules.<\/jats:p>","DOI":"10.1093\/omcr\/omaf204","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T11:43:13Z","timestamp":1756899793000},"source":"Crossref","is-referenced-by-count":0,"title":["Colorectal cancer in a man with silver-Russell syndrome: a case report"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7620-985X","authenticated-orcid":false,"given":"Farah","family":"Ibraik","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Al-Najah National University , Nablus, West Bank ,","place":["Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1977-1601","authenticated-orcid":false,"given":"Ibraheem","family":"Hammouri","sequence":"additional","affiliation":[{"name":"Clinical Research & Teaching Assistant, Faculty of Medicine and Health Sciences, Palestine Polytechnic University , Hebron, West Bank ,","place":["Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6484-5606","authenticated-orcid":false,"given":"Hasan","family":"Arafat","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Augusta Victoria Hospital , Jerusalem ,","place":["Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2919-4980","authenticated-orcid":false,"given":"Ahmad G","family":"Hammouri","sequence":"additional","affiliation":[{"name":"Radiology Department, Al-Ahli hospital , Hebron, West Bank ,","place":["Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Qahoush","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Augusta Victoria Hospital , Jerusalem ,","place":["Palestine"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"2025102907331301600_ref1","volume-title":"More about Silver Russell Syndrome","author":"Silver Russell Syndrome Global Alliance","year":"2024"},{"key":"2025102907331301600_ref2","doi-asserted-by":"publisher","first-page":"563","DOI":"10.2217\/epi-2015-0010","article-title":"New developments in silver\u2013Russell syndrome and implications for clinical practice","volume":"8","author":"Ishida","year":"2016","journal-title":"Epigenomics."},{"key":"2025102907331301600_ref3","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1136\/jmg.2007.053017","article-title":"The genetic aetiology of silver-Russell syndrome","volume":"45","author":"Abu-Amero","year":"2007","journal-title":"J Med Genet"},{"key":"2025102907331301600_ref4","doi-asserted-by":"publisher","first-page":"e1889","DOI":"10.1210\/clinem\/dgae423","article-title":"Approach to the patient with suspected silver-Russell syndrome","volume":"109","author":"Kurup","year":"2024","journal-title":"J Clin Endocrinol Metab"},{"key":"2025102907331301600_ref5","volume-title":"Russell-Silver Syndrome - Symptoms","author":"National Organization for Rare Disorders NORD","year":"2024"},{"key":"2025102907331301600_ref6","volume-title":"Russell-Silver Syndrome: Medlineplus genetics","author":"MedlinePlus","year":"2024"},{"key":"2025102907331301600_ref7","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1136\/jmedgenet-2019-106561","article-title":"Phenotype of genetically confirmed silver-Russell syndrome beyond childhood","volume":"57","author":"Lokulo-Sodipe","year":"2020","journal-title":"J Med Genet"},{"key":"2025102907331301600_ref8","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1159\/000447413","article-title":"Silver-Russell syndrome and Beckwith-Wiedemann syndrome: opposite phenotypes with heterogeneous molecular Etiology","volume":"7","author":"\u00d5unap","year":"2016","journal-title":"Mol Syndromol"},{"key":"2025102907331301600_ref9","doi-asserted-by":"publisher","DOI":"10.4267\/2042\/44573","article-title":"Silver Russell syndrome","volume":"13","author":"Piccione","journal-title":"Atlas Genet Cytogenet Oncol"},{"key":"2025102907331301600_ref10","doi-asserted-by":"publisher","first-page":"e2001","DOI":"10.1210\/clinem\/dgae074","article-title":"Body composition and metabolism in adults with molecularly-confirmed silver-Russell syndrome","volume":"109","author":"Lokulo-Sodipe","year":"2024","journal-title":"J Clin Endocrinol Metab"},{"key":"2025102907331301600_ref11","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1210\/jc.2017-02589","article-title":"Clinical manifestations and metabolic outcomes of seven adults with silver-Russell syndrome","volume":"103","author":"Patti","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"2025102907331301600_ref12","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/B978-0-12-380866-0.60006-X","article-title":"Genomic imprinting syndromes and cancer","volume":"70","author":"Lim","year":"2010","journal-title":"Adv Genet"},{"key":"2025102907331301600_ref13","doi-asserted-by":"publisher","first-page":"4915","DOI":"10.3390\/ijms20194915","article-title":"Insulin-like growth factor 2 (IGF2) Signaling in colorectal cancer\u2014from basic research to potential clinical applications","volume":"20","author":"Kasprzak","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2025102907331301600_ref14","doi-asserted-by":"publisher","first-page":"676","DOI":"10.3390\/cancers16030676","article-title":"The impact of the gut microbiome, environment, and diet in early-onset colorectal cancer development","volume":"16","author":"Dai","year":"2024","journal-title":"Cancers (Basel)"},{"key":"2025102907331301600_ref15","volume-title":"Colorectal cancer: screening. 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