{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T12:56:57Z","timestamp":1764161817930,"version":"3.46.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Oligosecretory multiple myeloma (OSMM) is a rare subtype of plasma cell dyscrasia that poses significant diagnostic challenges due to the absence of a clear monoclonal (M) spike on serum protein electrophoresis. We report the case of a 64-year-old woman with a history of ovarian tumor who presented with progressive fatigue, weight loss, bone pain, anaemia, hypercalcemia, and renal dysfunction. Despite the absence of a definitive M-spike, further immunochemical testing revealed discrete IgG-kappa bands on immunofixation, skeletal x-rays showed extensive osteolytic lesions. A bone marrow biopsy confirmed a diagnosis of OSMM. This case highlights the importance of considering oligosecretory variants in patients with clinical and radiological features suggestive of myeloma, even when routine tests appear normal, and illustrates how comprehensive evaluation with immunofixation and bone marrow examination can prevent diagnostic delays and allow timely initiation of treatment in these diagnostically challenging cases.<\/jats:p>","DOI":"10.1093\/omcr\/omaf242","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T11:45:54Z","timestamp":1760442354000},"source":"Crossref","is-referenced-by-count":0,"title":["Unmasking Oligosecretory multiple myeloma: a case report highlighting diagnostic pitfalls"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0866-2183","authenticated-orcid":false,"given":"Carlos","family":"Sol\u00f3rzano Flores","sequence":"first","affiliation":[{"name":"Faculty of Medical Sciences, National Autonomous University of Honduras (UNAH), 3RQ3+73W Calle La Salud, Edificio Administrativo , Tegucigalpa 11101 ,","place":["Honduras"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8861-4352","authenticated-orcid":false,"given":"Adolfo","family":"Izaguirre","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, National Autonomous University of Honduras (UNAH), 3RQ3+73W Calle La Salud, Edificio Administrativo , Tegucigalpa 11101 ,","place":["Honduras"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7035-5689","authenticated-orcid":false,"given":"Evangie","family":"Bravo Monroig","sequence":"additional","affiliation":[{"name":"School of Medicine, Autonomous University of Guadalajara (UAG) , Av Montevideo 3035, Lomas del Valle, Guadalajara, Jalisco 44100 ,","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9987-483X","authenticated-orcid":false,"given":"Jhiamluka","family":"Solano","sequence":"additional","affiliation":[{"name":"Department of Cardiology,York Hospital & Royal College of Physician , Wigginton Road, York YO31 8HE ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"2025112607525212000_ref1","doi-asserted-by":"publisher","first-page":"1527198","DOI":"10.3389\/fpubh.2025.1527198","article-title":"Global, regional and national epidemiological trends of multiple myeloma from 1990 to 2021: a systematic analysis of the global burden of disease study 2021","volume":"13","author":"Zhuge","year":"2025","journal-title":"Front Public 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