{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T12:57:09Z","timestamp":1764161829517,"version":"3.46.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Thyroid hormone is essential in human metabolism. Hypothyroidism causes bradycardia, sinus pause, sinus arrest, and the most severe form, myxedema coma, and cardiopulmonary arrest. Most cardiovascular manifestations secondary to hypothyroidism are reversible with timely thyroid hormone replacement. Herein, we report a case of a 53-year-old woman with hypothyroidism who experienced episodes of prolonged sinus arrest, which resolved following temporary pacing and initiation of levothyroxine therapy. Factors such as seasonal variation, medication noncompliance, recent viral illness, and concurrent escitalopram use likely contributed to her presentation. This case highlights the importance of prompt recognition and management of hypothyroid-related cardiac arrhythmias.<\/jats:p>","DOI":"10.1093\/omcr\/omaf247","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T12:09:30Z","timestamp":1761307770000},"source":"Crossref","is-referenced-by-count":0,"title":["Unraveling the cardiac consequences of hypothyroidism: a case report of sinus arrest and bradycardia exacerbated by seasonal changes, escitalopram and medication noncompliance"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8831-3690","authenticated-orcid":false,"given":"May Thu","family":"Kyaw","sequence":"first","affiliation":[{"name":"Heart and Vascular Center, Victoria hospital , Mayangone township, 11061 Yangon ,","place":["Myanmar"]},{"name":"Internal Medicine, University of Medicine 2 , Yangon ,","place":["Myanmar"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Smitt","sequence":"additional","affiliation":[{"name":"Internal Medicine, University of Medicine 2 , Yangon ,","place":["Myanmar"]},{"name":"Internal Medicine, OSC Hospital , Yangon ,","place":["Myanmar"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"2025112607532539800_ref1","doi-asserted-by":"publisher","first-page":"55","DOI":"10.14797\/mdcj-13-2-55","article-title":"Hypothyroidism and the heart","volume":"13","author":"Udovcic","year":"2017","journal-title":"Methodist Debakey Cardiovasc J"},{"key":"2025112607532539800_ref2","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1002\/jgf2.267","article-title":"Myxedema coma accompanied by sick sinus syndrome and hypoventilation: a case report","volume":"20","author":"Harada","year":"2019","journal-title":"J Gen Fam Med"},{"key":"2025112607532539800_ref3","doi-asserted-by":"publisher","first-page":"bvac054","DOI":"10.1210\/jendso\/bvac054","article-title":"Seasonal variation in thyroid function in over 7,000 healthy subjects in an iodine-sufficient area and literature review","volume":"6","author":"Yamada","year":"2022","journal-title":"J Endocr Soc"},{"key":"2025112607532539800_ref4","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1161\/01.cir.96.2.592","article-title":"Effects of thyroid hormone on cardiac beta-adrenergic responsiveness in conscious baboons","volume":"96","author":"Hoit","year":"1997","journal-title":"Circulation"},{"key":"2025112607532539800_ref5","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1113\/jphysiol.2002.032847","article-title":"Acute exposure to thyroid hormone increases Na+ current and intracellular Ca2+ in cat atrial myocytes","volume":"546","author":"Wang","year":"2003","journal-title":"J Physiol"},{"key":"2025112607532539800_ref6","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.jjcc.2012.05.012","article-title":"Atrioventricular block in patients with thyroid dysfunction: prognosis after treatment with hormone supplementation or antithyroid medication","volume":"60","author":"Ozcan","year":"2012","journal-title":"J Cardiol"},{"key":"2025112607532539800_ref7","doi-asserted-by":"publisher","first-page":"104830","DOI":"10.1016\/j.amsu.2022.104830","article-title":"Overt hypothyroidism complicated by complete heart block and severe hyperlipidemia. A case report","volume":"84","author":"Mire Waberi","year":"2022","journal-title":"Ann Med Surg"},{"key":"2025112607532539800_ref8","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1089\/thy.2014.0028","article-title":"Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement","volume":"24","author":"Jonklaas","year":"2014","journal-title":"Thyroid"},{"key":"2025112607532539800_ref9","doi-asserted-by":"publisher","first-page":"75","DOI":"10.18773\/austprescr.2004.06","article-title":"Taking care of thyroxine","volume":"27","author":"Roberts","year":"2004","journal-title":"Aust Prescr"},{"key":"2025112607532539800_ref10","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1016\/j.euroneuro.2013.05.011","article-title":"The cardiovascular safety profile of escitalopram","volume":"23","author":"Thase","year":"2013","journal-title":"Eur Neuropsychopharmacol"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2025\/11\/omaf247\/65549688\/omaf247.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2025\/11\/omaf247\/65549688\/omaf247.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T12:53:33Z","timestamp":1764161613000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omaf247\/8343281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":10,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11,26]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omaf247","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,11]]},"published":{"date-parts":[[2025,11]]},"article-number":"omaf247"}}