{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T12:56:23Z","timestamp":1764161783836,"version":"3.46.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gestational trophoblastic disease (GTD) encompasses a spectrum of premalignant and malignant conditions arising from trophoblastic tissue. This case highlights an unusual and severe progression of a partial hydatidiform mole complicated by preeclampsia, hyperthyroidism, torsion of a theca-lutein cyst, and ultimately metastatic choriocarcinoma. The patient\u2019s course illustrates the importance of early recognition, close monitoring, and multidisciplinary management. This rare and instructive presentation underscores the malignant potential of partial moles. Case: A 36-year-old patient who presented with abdominal pain and vaginal bleeding, associated with hypertension and a beta-human chorionic gonadotropin (\u03b2-hCG) of 1561722.6 mIU\/mL. Ultrasound revealed a pattern suggestive of a partial mole. Manual vacuum aspiration (MVA) was performed, finding 750\u00a0mL of vesicular tissue. Histopathological examination confirmed a partial mole. Days later, the patient developed torsion of a theca lutein cyst, which required exploratory laparotomy. During follow-up, \u03b2-hCG levels progressively increased, indicating persistent trophoblastic disease. The patient was referred to an oncology center, where she was diagnosed with choriocarcinoma with pulmonary metastases. She is currently undergoing her first cycle of chemotherapy. The chosen regimen was etoposide and cisplatin, administered over four cycles. This decision was guided by a FIGO risk score assessment, which placed the patient in the low to intermediate-risk category. The initial response was favorable, with no observed complications during the first two cycles.<\/jats:p>","DOI":"10.1093\/omcr\/omaf248","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T12:00:13Z","timestamp":1761307213000},"source":"Crossref","is-referenced-by-count":0,"title":["A rare concomitant association: partial hydatidiform mole with preeclampsia without severe features, hyperthyroidism, torsion of a theca-lutein cyst and choriocarcinoma with pulmonary metastases"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1025-8821","authenticated-orcid":false,"given":"Maria F","family":"Peralta-Reza","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, Hospital General Dr. Manuel Gea Gonz\u00e1lez , Calzada de Tlalpan 4800, Belisario Dom\u00ednguez Secci\u00f3n 16, Tlalpan, Ciudad de M\u00e9xico 14080 ,","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5042-1014","authenticated-orcid":false,"given":"Isela J","family":"Barrita-Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Department of Maternal-Fetal Medicine, Hospital General Dr. Manuel Gea Gonz\u00e1lez , Calzada de Tlalpan 4800, Belisario Dom\u00ednguez Secci\u00f3n 16, Tlalpan, Ciudad de M\u00e9xico 14080 ,","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0266-7616","authenticated-orcid":false,"given":"Alejandra","family":"Herrera-Ortiz","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Hospital General Dr. Manuel Gea Gonz\u00e1lez , Calzada de Tlalpan 4800, Belisario Dom\u00ednguez Secci\u00f3n 16, Tlalpan, Ciudad de M\u00e9xico 14080 ,","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8970-0090","authenticated-orcid":false,"given":"A\u00edda F","family":"Gonz\u00e1lez-Zimbr\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Hospital General Dr. Manuel Gea Gonz\u00e1lez , Calzada de Tlalpan 4800, Belisario Dom\u00ednguez Secci\u00f3n 16, Tlalpan, Ciudad de M\u00e9xico 14080 ,","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4040-3314","authenticated-orcid":false,"given":"Natalia M","family":"S\u00e1nchez-Solis","sequence":"additional","affiliation":[{"name":"Department of Hysteroscopy, Hospital General Dr. Manuel Gea Gonz\u00e1lez , Calzada de Tlalpan 4800, Belisario Dom\u00ednguez Secci\u00f3n 16, Tlalpan, Ciudad de M\u00e9xico 14080 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16-week partial molar pregnancy","volume":"17","author":"Core","year":"2024","journal-title":"BMJ Case Rep CP"},{"key":"2025112607515981700_ref8","doi-asserted-by":"publisher","first-page":"36","DOI":"10.11648\/j.jgo.20190702.12","article-title":"Conservative management, follow-up and perinatal outcomes after gestational trophoblastic disease with coexistent normal fetus: case report","volume":"7","author":"Herrera-Ortiz","year":"2019","journal-title":"J Gynecol Obstet"},{"key":"2025112607515981700_ref9","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1097\/GRF.0b013e31802f17fc","article-title":"Enfermedad trofobl\u00e1stica gestacional","volume":"50","author":"Garner","year":"2007","journal-title":"Obstet Ginecol Clin"}],"container-title":["Oxford Medical Case 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