{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T07:55:09Z","timestamp":1766735709256,"version":"3.48.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bartter Syndrome (BS) is a genetic disorder affecting the renal tubules, leading to elevated levels of renin, angiotensin, and aldosterone, along with metabolic alkalosis, while maintaining normal blood pressure. It is also associated with laboratory abnormalities such as hypocalcemia, hypokalemia, hypomagnesemia, and hyponatremia, which may result in neurological complications including seizures and loss of consciousness. These findings necessitate consideration of important differential diagnoses such as Gitelman syndrome and cystic fibrosis, underscoring the importance of confirming the diagnosis of this serious condition, giving it appropriate attention, and initiating early treatment to prevent advanced complications. We report the case of a 36-year-old Jordanian male with a medical history of Bartter Syndrome and chronic kidney disease, who presented to the emergency department in a coma with generalized seizures due to severe electrolyte imbalances. His condition was further complicated by a genetic predisposition and a family history of Bartter Syndrome, with genetic testing confirming mutations in the CLCNKB gene. This rare case of Bartter Syndrome type III, in which the patient progressed to the stage of hemodialysis, illustrates the complexities of diagnosis and management, and emphasizes the importance of continuous care and regular follow-up.<\/jats:p>","DOI":"10.1093\/omcr\/omaf262","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T14:02:43Z","timestamp":1762264963000},"source":"Crossref","is-referenced-by-count":0,"title":["Complexities of Bartter Syndrome Type III: A Case Study in Jordan"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2970-7379","authenticated-orcid":false,"given":"Hamdah","family":"Hanifa","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Kalamoon , Al-Nabk ,","place":["Syria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumna","family":"Al-Badareen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Mutah University , Karak ,","place":["Jordan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malak Mbarak","family":"Al-Refaai","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Kalamoon , Al-Nabk ,","place":["Syria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nafeaa M","family":"Ganama","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Kalamoon , Al-Nabk ,","place":["Syria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Sameeh","family":"Alabrash","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Al-Wataniya Private University , Hama ,","place":["Syria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basil","family":"Alsaleh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tbilisi State Medical University , Tbilisi ,","place":["Georgia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"2025122602495895400_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgmr.2024.101112","article-title":"Clinical, genetic characteristics and outcome of four Chinese patients with Bartter syndrome type 3: Further insight into a genotype-phenotype correlation","volume":"40","author":"Piao","year":"2024","journal-title":"Mol Genet Metab Reports."},{"key":"2025122602495895400_ref2","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.injms.2015.06.004","article-title":"Classical Bartter syndrome \u2013 A case report","volume":"6","author":"Mali","year":"2015","journal-title":"Indian J Med Spec."},{"key":"2025122602495895400_ref3","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1186\/s12881-019-0869-9","article-title":"A novel CLCNKB mutation in a Chinese girl with classic Bartter syndrome: a case report","volume":"20","author":"Zhu","year":"2019","journal-title":"BMC Med Genet."},{"key":"2025122602495895400_ref4","doi-asserted-by":"publisher","first-page":"e36120","DOI":"10.7759\/cureus.36120","volume-title":"A Rare Presentation of Adult-Onset Bartter Syndrome: A Case Report","author":"Alla","year":"2023"},{"key":"2025122602495895400_ref5","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59091638","volume-title":"Bartter Syndrome: A Systematic Review of Case Reports and Case Series","author":"Qasba","year":"2023"},{"key":"2025122602495895400_ref6","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1186\/s13256-018-1752-6","article-title":"Bartter syndrome-like phenotype in a patient with diabetes: a case report","volume":"12","author":"Dalugama","year":"2018","journal-title":"J Med Case Rep."},{"key":"2025122602495895400_ref7","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1172\/JCI109487","article-title":"Effect of prostaglandin E2 on chloride transport across the rabbit thick ascending limb of Henle. Selective inhibitions of the medullary portion","volume":"64","author":"Stokes","year":"1979","journal-title":"J Clin Invest."},{"key":"2025122602495895400_ref8","author":"Bokhari","year":"2025"},{"key":"2025122602495895400_ref9","doi-asserted-by":"publisher","first-page":"p. 2050313X241233117","DOI":"10.1177\/2050313X241233117","article-title":"Bartter syndrome in a female infant: A rare case report from Syria","volume":"12","author":"Hanifa","year":"2024","journal-title":"SAGE open medical case reports. 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Nephrol."}],"container-title":["Oxford Medical Case 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