{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T05:16:04Z","timestamp":1767071764087,"version":"3.48.0"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Progressive supranuclear palsy-Richardson syndrome (PSP-RS) is a sporadic atypical parkinsonian disorder typically resistant to levodopa. While most cases are neurodegenerative, various conditions (genetic, vascular, infectious, or paraneoplastic) can mimic this phenotype, termed PSP-like or PSP mimics. Although paraneoplastic PSP is extremely rare, it is important to recognize because of its potential reversibility. The diagnosis can be particularly challenging, especially when classical tumor markers or imaging fail to identify a clear neoplastic origin. Here, we describe a 39-year-old man with an Anti-Ri\u2013mediated PSP-like syndrome in whom an extensive evaluation, including surgical removal of two suspicious sites (thymus and testis), failed to identify an underlying tumor. The patient presented with rapidly progressive symptoms characteristic of PSP-RS, raising clinical suspicion for a paraneoplastic cause. We also review the literature on paraneoplastic PSP.<\/jats:p>","DOI":"10.1093\/omcr\/omaf270","type":"journal-article","created":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T12:53:44Z","timestamp":1763297624000},"source":"Crossref","is-referenced-by-count":0,"title":["Paraneoplastic progressive Supranuclear palsy: a case report and literature review"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5573-3784","authenticated-orcid":false,"given":"Kaoutar","family":"Simma","sequence":"first","affiliation":[{"name":"Hassan II University of Casablanca, Faculty of Medicine and Pharmacy of Casablanca , Rue Tarik Ibn Ziad, Casablanca 20100 ,","place":["Morocco"]},{"name":"Department of Neurology, CHU Ibn Rochd , Casablanca ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3774-5704","authenticated-orcid":false,"given":"Asmae","family":"Sikkal","sequence":"additional","affiliation":[{"name":"Hassan II University of Casablanca, Faculty of Medicine and Pharmacy of Casablanca , Rue Tarik Ibn Ziad, Casablanca 20100 ,","place":["Morocco"]},{"name":"Department of Neurology, CHU Ibn Rochd , Casablanca ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8124-7651","authenticated-orcid":false,"given":"Hajar","family":"Khattab","sequence":"additional","affiliation":[{"name":"Hassan II University of Casablanca, Faculty of Medicine and Pharmacy of Casablanca , Rue Tarik Ibn Ziad, Casablanca 20100 ,","place":["Morocco"]},{"name":"Department of Neurology, CHU Ibn Rochd , Casablanca ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5656-8669","authenticated-orcid":false,"given":"Kamal","family":"Haddouali","sequence":"additional","affiliation":[{"name":"Hassan II University of Casablanca, Faculty of Medicine and Pharmacy of Casablanca , Rue Tarik Ibn Ziad, Casablanca 20100 ,","place":["Morocco"]},{"name":"Department of Neurology, CHU Ibn Rochd , Casablanca ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4580-2774","authenticated-orcid":false,"given":"Salma","family":"Bellakhdar","sequence":"additional","affiliation":[{"name":"Hassan II University of Casablanca, Faculty of Medicine and Pharmacy of Casablanca , Rue Tarik Ibn Ziad, Casablanca 20100 ,","place":["Morocco"]},{"name":"Department of Neurology, CHU Ibn Rochd , Casablanca ,","place":["Morocco"]},{"name":"Laboratory of Genetics and Molecular Pathology, Faculty of Medicine and Pharmacy , Casablanca ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1208-8449","authenticated-orcid":false,"given":"Bouchra","family":"EL Moutawakil","sequence":"additional","affiliation":[{"name":"Hassan II University of Casablanca, Faculty of Medicine and Pharmacy of Casablanca , Rue Tarik Ibn Ziad, Casablanca 20100 ,","place":["Morocco"]},{"name":"Department of Neurology, CHU Ibn Rochd , Casablanca ,","place":["Morocco"]},{"name":"Laboratory of Genetics and Molecular Pathology, Faculty of Medicine and Pharmacy , Casablanca ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4342-7499","authenticated-orcid":false,"given":"Mohamed Abdoh","family":"Rafai","sequence":"additional","affiliation":[{"name":"Hassan II University of Casablanca, Faculty of Medicine and Pharmacy of Casablanca , Rue Tarik Ibn Ziad, Casablanca 20100 ,","place":["Morocco"]},{"name":"Department of Neurology, CHU Ibn Rochd , Casablanca ,","place":["Morocco"]},{"name":"Research Laboratory on Nervous System Diseases, Neurosensory Diseases and Disability, Faculty of Medicine and Pharmacy , Casablanca ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0870-1808","authenticated-orcid":false,"given":"Hicham","family":"EL Otmani","sequence":"additional","affiliation":[{"name":"Hassan II University of Casablanca, Faculty of Medicine and Pharmacy of Casablanca , Rue Tarik Ibn Ziad, Casablanca 20100 ,","place":["Morocco"]},{"name":"Department of Neurology, CHU Ibn Rochd , Casablanca ,","place":["Morocco"]},{"name":"Laboratory of Genetics and Molecular Pathology, Faculty of Medicine and Pharmacy , Casablanca ,","place":["Morocco"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"2025123000120771600_ref1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/bs.irn.2019.10.013","article-title":"Progressive supranuclear palsy","volume":"149","author":"Giagkou","year":"2019","journal-title":"Int Rev Neurobiol"},{"key":"2025123000120771600_ref2","doi-asserted-by":"publisher","first-page":"804385","DOI":"10.3389\/fnagi.2022.804385","article-title":"Differential diagnosis of rare subtypes of progressive supranuclear palsy and PSP-like syndromes\u2014infrequent manifestations of the most common form of atypical parkinsonism","volume":"14","author":"Krzosek","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"2025123000120771600_ref3","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.neurol.2023.02.070","article-title":"PSP-Richardson syndrome mimics: an overview and pragmatic approach","volume":"180","author":"Necp\u00e1l","year":"2024","journal-title":"Rev Neurol (Paris)"},{"key":"2025123000120771600_ref4","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.jocn.2016.02.032","article-title":"Paraneoplastic syndrome mimicking progressive supranuclear palsy","volume":"32","author":"Dash","year":"2016","journal-title":"J Clin Neurosci"},{"key":"2025123000120771600_ref5","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.3390\/biomedicines11051406","article-title":"Paraneoplastic neurological syndromes of the central nervous system: pathophysiology, diagnosis, and treatment","volume":"11","author":"Marsili","year":"2023","journal-title":"Biomedicines."},{"key":"2025123000120771600_ref6","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.3390\/brainsci14101012","article-title":"Autoimmune encephalitis and paraneoplastic neurological syndromes with progressive supranuclear palsy-like manifestations","volume":"14","author":"Yamahara","year":"2024","journal-title":"Brain Sci"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2025\/12\/omaf270\/66128240\/omaf270.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2025\/12\/omaf270\/66128240\/omaf270.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T05:12:12Z","timestamp":1767071532000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omaf270\/8404880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":6,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12,24]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omaf270","relation":{},"ISSN":["2053-8855"],"issn-type":[{"type":"electronic","value":"2053-8855"}],"subject":[],"published-other":{"date-parts":[[2025,12]]},"published":{"date-parts":[[2025,12]]},"article-number":"omaf270"}}