{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T21:16:00Z","timestamp":1771449360857,"version":"3.50.1"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Skin metastasis secondary to visceral malignancy is a rare but poor prognostic occurrence. We report a rare case of gastroesophageal junction (GEJ) adenocarcinoma with skin metastases, highlighting the challenges in managing such cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 63-year-old male diagnosed with stage IV Siewert 3 GEJ adenocarcinoma with initial extensive skin metastases. Palliative radiation and four cycles of first-line FOLFOX resulted in progression and new skin lesions. A second-line FOLFIRI and third-lines taxane regimens failed to yield clinical improvement and stop progression. His disease worsened with widespread metastases including omentum and peritoneum. He died 9 months after initial presentation due to intestinal perforation secondary to neutropenic fever.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Skin metastases from GEJ adenocarcinoma are associated with aggressive disease chemotherapy resistance. A multidisciplinary approach, palliative care, and novel strategies are essential for managing such cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/omcr\/omaf274","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T12:31:34Z","timestamp":1768307494000},"source":"Crossref","is-referenced-by-count":0,"title":["Advanced gastroesophageal junction adenocarcinoma with skin involvement: a multidisciplinary perspective"],"prefix":"10.1093","volume":"2026","author":[{"given":"Kholoud","family":"Alqasem","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, King Hussein Cancer Center , Amman ,","place":["Jordan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2295-1945","authenticated-orcid":false,"given":"Sakhr","family":"Alshwayyat","sequence":"additional","affiliation":[{"name":"Research Center, King Hussein Cancer Center , Amman ,","place":["Jordan"]},{"name":"Princess 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