{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:30:51Z","timestamp":1787009451125,"version":"build-2736575974"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Syphilis, caused by Treponema pallidum, is a re-emerging infectious disease with diverse clinical manifestations. While primary syphilis often goes unnoticed, secondary syphilis is characterized by systemic symptoms and variable skin lesions, earning it the epithet \u2018the great imitator\u2019. Histologically, secondary syphilis typically shows a plasma cell-rich dermal infiltrate, whereas granulomatous inflammation is rare. This report describes a case of nodular secondary syphilis with granulomatous inflammation in a 22-year-old woman who presented with persistent erythematous nodules on the face. Initial mismanagement with corticosteroids delayed the diagnosis, which was later confirmed by histopathology and positive serologic tests. Treatment with benzathine penicillin G led to complete resolution of the lesions. The case highlights the importance of recognizing atypical presentations of syphilis, especially granulomatous forms, in the differential diagnosis. Serologic testing remains essential for confirmation, and benzathine penicillin is the treatment of choice for all stages of syphilis.<\/jats:p>","DOI":"10.1093\/omcr\/omaf277","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T12:33:31Z","timestamp":1765197211000},"source":"Crossref","is-referenced-by-count":1,"title":["Secondary syphilis: a nodular presentation with granulomatous inflammation\u2014a case report"],"prefix":"10.1093","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6835-0017","authenticated-orcid":false,"given":"Maryam","family":"Ghaleb","sequence":"first","affiliation":[{"name":"Dermatology Department, Mohammed VI University Hospital, Faculty of medicine and pharmacy, Abdelmalek Essa\u00e2di University , Route de Rabat Km 17 BP 398, Gzinaya, Tangier ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ouiame","family":"El jouari","sequence":"additional","affiliation":[{"name":"Dermatology Department, Mohammed VI University Hospital, Faculty of medicine and pharmacy, Abdelmalek Essa\u00e2di University , Route de Rabat Km 17 BP 398, Gzinaya, Tangier ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8169-3341","authenticated-orcid":false,"given":"Kaoutar","family":"Benchekroun","sequence":"additional","affiliation":[{"name":"Dermatology Department, Mohammed VI University Hospital, Faculty of medicine and pharmacy, Abdelmalek Essa\u00e2di University , Route de Rabat Km 17 BP 398, Gzinaya, Tangier ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim","family":"Gallouj","sequence":"additional","affiliation":[{"name":"Dermatology Department, Mohammed VI University Hospital, Faculty of medicine and pharmacy, Abdelmalek Essa\u00e2di University , Route de Rabat Km 17 BP 398, Gzinaya, Tangier ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"2025122602502043300_ref1","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1111\/CUP.12293","article-title":"Nodular secondary syphilis with associated granulomatous inflammation: case report and literature review","volume":"41","author":"Rysgaard","year":"2014","journal-title":"J Cutan Pathol"},{"key":"2025122602502043300_ref2","doi-asserted-by":"publisher","first-page":"e241","DOI":"10.1111\/ijd.15337","article-title":"Sporotrichoid second- ary syphilis","volume":"60","author":"Mazori","year":"2021","journal-title":"Int J Dermatol"},{"key":"2025122602502043300_ref3","doi-asserted-by":"publisher","first-page":"e25","DOI":"10.1016\/j.amjmed.2022.09.014","article-title":"Granulomatous secondary syphilis: an uncommon presentation of the great imitator","volume":"136","author":"Yousefian","year":"2022","journal-title":"Am J Med"},{"key":"2025122602502043300_ref4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.5070\/D330J0S529","article-title":"Nodular secondary syphilis","volume":"9","author":"Dave","year":"2003","journal-title":"Dermatol Online J"},{"key":"2025122602502043300_ref5","first-page":"27","article-title":"Papulonodular secondary syphilis in a 52-year-old non-HIV heterosexual patient","volume":"19","author":"Breznik","year":"2010","journal-title":"Acta Dermatovenerol Alp Panonica Adriat"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2025\/12\/omaf277\/66128295\/omaf277.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2025\/12\/omaf277\/66128295\/omaf277.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T07:50:26Z","timestamp":1766735426000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omaf277\/8404889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":5,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12,24]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omaf277","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,12]]},"published":{"date-parts":[[2025,12]]},"article-number":"omaf277"}}