{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:08:47Z","timestamp":1777586927940,"version":"3.51.4"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 28-year-old woman presented in the emergency with sudden, painless bilateral loss of vision over one week. Fundus examination revealed multiple white-centered retinal hemorrhages (Roth spots), cotton wool spots, and multiple retinal hemorrhages in both eyes, indicative of anemic retinopathy. Laboratory evaluation showed profound pancytopenia: hemoglobin 2.3\u00a0g\/dl, leukocyte count 3.0\u2009\u00d7\u200910^9\/l, platelet count 92\u2009\u00d7\u200910^9\/l, with elevated mean corpuscular volume (107\u00a0fl). Serum cobalamin (vitamin B12) was 57\u00a0pg\/ml and folate 3.5\u00a0ng\/ml, consistent with megaloblastic anemia due to vitamin B12 deficiency. Peripheral blood smear confirmed macro-ovalocytes and hypersegmented neutrophils. The patient was managed emergently with packed red blood cell transfusions and parenteral vitamin B 12 and folate supplementation. Two weeks later, her hemoglobin had improved to 10.1\u00a0g\/dl, and follow-up fundus examination showed marked resolution of retinal hemorrhages and Roth spots with partial visual recovery. This case highlights that severe megaloblastic anemia can present as an acute ophthalmic emergency.<\/jats:p>","DOI":"10.1093\/omcr\/omaf305","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T12:44:39Z","timestamp":1767876279000},"source":"Crossref","is-referenced-by-count":1,"title":["From vision to vital signs: uncovering severe Anemia through retinal clues!"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5239-8956","authenticated-orcid":false,"given":"Aswini","family":"Devi S B","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Deen Dayal Upadhyay Hospital, Government of NCT of Delhi , Hari Nagar, West Delhi, New Delhi 110064 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nishant","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Deen Dayal Upadhyay Hospital, Government of NCT of Delhi , Hari Nagar, West Delhi, New Delhi 110064 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaifali","family":"Khandpur","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Deen Dayal Upadhyay Hospital, Government of NCT of Delhi , Hari Nagar, West Delhi, New Delhi 110064 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilpa","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Deen Dayal Upadhyay Hospital, Government of NCT of Delhi , Hari Nagar, West Delhi, New Delhi 110064 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"2026021815410931800_ref1","doi-asserted-by":"publisher","first-page":"152","DOI":"10.37845\/ret.vit.2024.33.24","article-title":"Megaloblastic anemia-associated retinopathy: a rare case","volume":"33","author":"Arican","year":"2024","journal-title":"Ret Vit"},{"key":"2026021815410931800_ref2","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.jpeds.2022.07.047","article-title":"Retinopathy of megaloblastic Anemia: treatable and reversible","volume":"250","author":"Sambhu Hema","year":"2022","journal-title":"J Pediatr"},{"key":"2026021815410931800_ref3","doi-asserted-by":"publisher","DOI":"10.1177\/2050313X241292527","article-title":"Biermer\u2019s disease unveiled: bilateral macular hemorrhage as a rare manifestation-a case report","volume":"12","author":"Sara","year":"2024","journal-title":"SAGE Open Med Case Rep"},{"key":"2026021815410931800_ref4","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1034\/j.1600-0609.2001.00539.x","article-title":"Prevalence of retinopathy in patients with anemia or thrombocytopenia","volume":"67","author":"Carraro","year":"2001","journal-title":"European J of Haematology"},{"key":"2026021815410931800_ref5","doi-asserted-by":"publisher","first-page":"4421","DOI":"10.4103\/jfmpc.jfmpc_577_20","article-title":"The eye: a lifesaver! An unusual case of Anemic retinopathy secondary to malnutrition and its recovery","volume":"9","author":"Jojo","year":"2020","journal-title":"J Family Med Prim Care"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2026\/2\/omaf305\/66975387\/omaf305.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2026\/2\/omaf305\/66975387\/omaf305.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T20:41:11Z","timestamp":1771447271000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omaf305\/8489642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,18]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omaf305","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,2]]},"published":{"date-parts":[[2026,2]]},"article-number":"omaf305"}}