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A 31-year-old female with aquagenic keratoderma of the palms associated with palmoplantar hyperhidrosis presenting with wrinkling and hyperkeratosis within minutes of hand contact with water, resolving quickly after drying. While cystic fibrosis is a known association, most cases remain idiopathic. Treatment options such as 20% aluminum hydroxide, aluminum chloride (15%\u201320%), urea, salicylic acid, and botulinum toxin can be challenging, with the patient being evaluated after treatment with 16% aluminum chloride.<\/jats:p>","DOI":"10.1093\/omcr\/omag001","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T12:41:02Z","timestamp":1767789662000},"source":"Crossref","is-referenced-by-count":0,"title":["Aquagenic palmar keratoderma associated with palmoplantar hyperhidrosis: a case report"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6129-5733","authenticated-orcid":false,"given":"Marah","family":"Mansour","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Tartous University , 8th March st, Mustafa mosque, Tartous, Syria 0000 ,","place":["Syrian Arab Republic"]},{"name":"Division of Colon and Rectal Surgery, Department of Surgery, Mayo clinic , Rochester, MN ,","place":["United States of 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