{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T16:56:37Z","timestamp":1771952197057,"version":"3.50.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The most common sites for breast cancer metastases include the bones, lungs, liver, and brain. Metastases in the GI tract are rare and predominantly originate from lobular breast cancer. Gastric involvement by invasive lobular carcinoma (ILC) is rare and can mimic primary gastric malignancies, leading to diagnostic challenges. Metastasis of ILC to the gallbladder is exceedingly rare and often identified incidentally during cholecystectomy performed for presumed benign conditions. We present a case of a 62-year-old female patient with symptoms of weight loss and dysphagia. After CT and gastroscopy, gastrectomy and cholecystectomy were performed due to suspicion of gastric carcinoma. Histology and immunohistochemical profiling, with estrogen receptor (ER), progesterone receptor (PR), E-cadherin, GATA3, Mammaglobin, and GCDFP-15, favored the diagnosis of lobular breast carcinoma metastasis over primary gastric adenocarcinoma. Awareness of these atypical presentations is crucial for accurate diagnosis and effective management, as misdiagnosis can result in suboptimal treatment strategies.<\/jats:p>","DOI":"10.1093\/omcr\/omag009","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:53:43Z","timestamp":1769086423000},"page":"158-161","source":"Crossref","is-referenced-by-count":0,"title":["Gallbladder and gastric metastasis as initial presentation of an undiagnosed primary lobular breast carcinoma"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8610-9119","authenticated-orcid":false,"given":"Blagica","family":"Krsteska","sequence":"first","affiliation":[{"name":"Institute of Pathology, Faculty of Medicine, University Ss. Cyril and Methodius , 50 Divizija 6, Skopje 1000 ,","place":["Republic of North Macedonia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanja","family":"Ivkovska","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Faculty of Medicine, University Ss. Cyril and Methodius , 50 Divizija 6, Skopje 1000 ,","place":["Republic of North Macedonia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanja","family":"Filipovski","sequence":"additional","affiliation":[{"name":"Department of histopathology and cytology, Clinical Hospital Acibadem-Sistina , Skupi 5A, Skopje 1000 \u00a0","place":["North Macedonia"]},{"name":"Faculty of Medical Sciences, Goce Delcev University , Krste Misirkov 10-a, Stip 2000 ,","place":["North Macedonia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Kubelka Sabit","sequence":"additional","affiliation":[{"name":"Department of histopathology and cytology, Clinical Hospital Acibadem-Sistina , Skupi 5A, Skopje 1000 \u00a0","place":["North Macedonia"]},{"name":"Faculty of Medical Sciences, Goce Delcev University , Krste Misirkov 10-a, Stip 2000 ,","place":["North Macedonia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dzengis","family":"Jasar","sequence":"additional","affiliation":[{"name":"Department of histopathology and cytology, Clinical Hospital Acibadem-Sistina , Skupi 5A, Skopje 1000 \u00a0","place":["North Macedonia"]},{"name":"Faculty of Medical Sciences, Goce Delcev University , Krste Misirkov 10-a, Stip 2000 ,","place":["North Macedonia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahir","family":"Senol","sequence":"additional","affiliation":[{"name":"University Surgical Hospital St. Naum Ohridski , 11 Octomvri 53, Skopje 1000 ,","place":["North Macedonia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Bogdanovska Todorovska","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Faculty of Medicine, University Ss. Cyril and Methodius , 50 Divizija 6, Skopje 1000 ,","place":["Republic of North Macedonia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"2026022410590930600_ref1","first-page":"13147","article-title":"Breast cancer with an initial gastrointestinal presentation: a case report and literature review","volume":"13","author":"Zhang","year":"2021","journal-title":"Am J Transl Res"},{"key":"2026022410590930600_ref2","doi-asserted-by":"publisher","first-page":"e01582","DOI":"10.14309\/crj.0000000000001582","article-title":"Covert breast cancer metastasis to the gastrointestinal tract: is extra vigilance needed?","volume":"12","author":"Wehbe","year":"2025","journal-title":"ACG Case Rep J"},{"key":"2026022410590930600_ref3","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.65852","article-title":"Gastrointestinal metastases from lobular breast carcinoma: a literature review","volume":"16","author":"Kioleoglou","year":"2024","journal-title":"Cureus."},{"key":"2026022410590930600_ref4","doi-asserted-by":"publisher","first-page":"49","DOI":"10.4322\/acr.2015.018","article-title":"Gastric metastasis as the first manifestation of an invasive lobular carcinoma of the breast","volume":"5","author":"D\u00f3ria","year":"2015","journal-title":"Autops Case Rep"},{"key":"2026022410590930600_ref5","doi-asserted-by":"crossref","first-page":"354","DOI":"10.12659\/AJCR.908039","article-title":"Gastric metastasis as the first presentation one year before diagnosis of primary breast cancer","volume":"19","author":"Woo","year":"2018","journal-title":"Am J Case Rep"},{"key":"2026022410590930600_ref6","doi-asserted-by":"crossref","first-page":"03000605241233988","DOI":"10.1177\/03000605241233988","article-title":"Gastric metastasis from breast cancer: five cases and a single-institutional review","volume":"52","author":"Cheng","year":"2024","journal-title":"J Int Med Res"},{"key":"2026022410590930600_ref7","doi-asserted-by":"crossref","first-page":"295","DOI":"10.2478\/amma-2023-0041","article-title":"Gallbladder metastasis from occult lobular breast carcinoma: a case report","volume":"69","author":"Dori\u0107","year":"2023","journal-title":"Acta Marisiensis - Seria Medica"},{"key":"2026022410590930600_ref8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/1477-7819-5-101","article-title":"Bilateral synchronous breast carcinomas followed by a metastasis to the gallbladder: a case report","volume":"5","author":"Zagouri","year":"2007","journal-title":"World J Surg Oncol"},{"key":"2026022410590930600_ref9","doi-asserted-by":"crossref","first-page":"105612","DOI":"10.1016\/j.ijscr.2021.01.106","article-title":"Metastatic lobular carcinoma of the breast found incidentally on pathology following cholecystectomy for chronic cholecystitis: a case report","volume":"80","author":"Salita","year":"2021","journal-title":"Int J Surg Case Rep"},{"key":"2026022410590930600_ref10","doi-asserted-by":"publisher","first-page":"e220451","DOI":"10.7326\/aimcc.2022.0451","article-title":"Metastatic lobular carcinoma of the breast masquerading as gallstone disease \u2013 a case report","volume":"1","author":"Ali","year":"2022","journal-title":"AIM Clinical Cases"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2026\/2\/158\/67092003\/omag009.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2026\/2\/158\/67092003\/omag009.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T15:59:14Z","timestamp":1771948754000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/2026\/2\/158\/8496125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,18]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omag009","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,2]]},"published":{"date-parts":[[2026,2]]}}}