{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T21:56:55Z","timestamp":1776722215001,"version":"3.51.2"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute pancreatitis (AP) is a gastrointestinal disorder frequently associated with gallstones, hypertriglyceridemia, and alcohol use. Drug-induced pancreatitis has been documented in the medical literature, with various medications implicated as potential triggers. We report a case of a 31-year-old man with hypertension who presented with severe upper abdominal pain and was diagnosed with AP. Extensive diagnostic evaluation excluded common causes, pointing towards losartan. Symptomatic management and cessation of losartan led to improvement. This is a rare instance of losartan-induced AP. The patient experienced symptoms after a year of use, suggesting that pancreatitis can occur at any time during therapy. The underlying mechanisms are unclear; however, they might include decreased bradykinin breakdown leading to localized pancreatic duct angioedema. This highlights the importance of differentiating drug-induced pancreatitis from idiopathic causes. This case highlights the importance of considering pancreatitis in differential diagnosis, particularly in patients lacking typical risk factors.<\/jats:p>","DOI":"10.1093\/omcr\/omag025","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T17:43:17Z","timestamp":1774287797000},"source":"Crossref","is-referenced-by-count":1,"title":["Timing insights in losartan-induced pancreatitis: a clinical case report"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3517-3481","authenticated-orcid":false,"given":"Suraj","family":"Karanjit","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Rural Health Education and Service Center , Kathmandu 44600 ,","place":["Nepal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6831-3221","authenticated-orcid":false,"given":"Nistha","family":"Shahi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Karnali Province Hospital , Birendranagar, Surkhet 21700 ,","place":["Nepal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7908-0164","authenticated-orcid":false,"given":"Kul Raj","family":"Shahi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Karnali Province Hospital , Birendranagar, Surkhet 21700 ,","place":["Nepal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2259-6232","authenticated-orcid":false,"given":"Dipendra","family":"Chapagain","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Patan Academy of Health Sciences, School of Medicine 44700 ,","place":["Nepal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay Bhushan","family":"Jha","sequence":"additional","affiliation":[{"name":"Research Unit, Nepal Medical Association 44600 ,","place":["Nepal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8350-2914","authenticated-orcid":false,"given":"Jeevan","family":"Gyawali","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chirayu National Hospital and Medical Institute (CNHMI) , Kathmandu 44600 ,","place":["Nepal"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"2026032313431467500_ref1","first-page":"e6253","article-title":"Losartan-induced pancreatitis","volume":"11","author":"Anwar","year":"2019","journal-title":"Cureus"},{"key":"2026032313431467500_ref2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.bpg.2010.02.002","article-title":"Drug induced pancreatitis","volume":"24","author":"Nitsche","year":"2010","journal-title":"Best Pract Res Clin 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Engl"},{"key":"2026032313431467500_ref6","doi-asserted-by":"crossref","first-page":"406","DOI":"10.2165\/00002018-199614060-00006","article-title":"Drug-induced pancreatitis","volume":"14","author":"Wilmink","year":"1996","journal-title":"Drug Saf"},{"key":"2026032313431467500_ref7","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/S0140-6736(05)79122-4","article-title":"Pancreatitis after losartan","volume":"351","author":"Birck","year":"1998","journal-title":"Lancet"},{"key":"2026032313431467500_ref8","first-page":"111","article-title":"Angiotensin receptors: structure, function, Signaling and clinical applications","volume":"1","author":"Singh","year":"2016","journal-title":"J Cell Signal"},{"key":"2026032313431467500_ref9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/08998280.2008.11928366","article-title":"Drug-induced acute pancreatitis","volume":"21","author":"Kaurich","year":"2008","journal-title":"Proc Bayl Univ Med Cent"},{"key":"2026032313431467500_ref10","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1159\/000028355","article-title":"Kallikrein-kinin system in acute pancreatitis: potential of B(2)-bradykinin antagonists and kallikrein inhibitors","volume":"60","author":"Griesbacher","year":"2000","journal-title":"Pharmacology."},{"key":"2026032313431467500_ref11","first-page":"45","article-title":"Drug-induced acute pancreatitis: a review","volume":"15","author":"Jones","year":"2015","journal-title":"Ochsner J"},{"key":"2026032313431467500_ref12","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.cgh.2006.11.023","article-title":"Drug-induced acute pancreatitis: an evidence-based review","volume":"5","author":"Badalov","year":"2007","journal-title":"Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc"},{"key":"2026032313431467500_ref13","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.7326\/0003-4819-127-11-199712010-00031","article-title":"Losartan-induced acute pancreatitis","volume":"127","author":"Bosch","year":"1997","journal-title":"Ann Intern Med"},{"key":"2026032313431467500_ref14","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.aprim.2014.02.003","article-title":"Pancreatitis aguda en un paciente tratado con losart\u00e1n","volume":"46","author":"Arellano","year":"2014","journal-title":"Aten Primaria"}],"container-title":["Oxford Medical Case 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