{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:01:33Z","timestamp":1777514493927,"version":"3.51.4"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Follicular lymphoma is an indolent B-cell non-Hodgkin lymphoma typically characterized by the t(14;18)(q32;q21) translocation resulting in B-cell lymphoma 2 (BCL2)\/immunoglobulin heavy chain (IGH) fusion. Nontranslocation variants are rare and may present with atypical clinical features that complicate diagnosis. The patient\u2019s presentation initially resembled infectious mononucleosis due to a false-positive monospot test; however, subsequent workup revealed follicular lymphoma lacking the canonical BCL2\/IGH translocation. Extensive infectious, autoimmune, and nutritional evaluation was unrevealing. Cervical lymph node biopsy demonstrated follicular lymphoma with uniform BCL2 expression but no detectable BCL2\/IGH fusion by Fluorescence in Situ Hybridization (FISH), confirming nontranslocation follicular lymphoma. The patient achieved complete remission after six cycles of obinutuzumab, cyclophosphamide, vincristine, and prednisone. This case illustrates a rare presentation of nontranslocation follicular lymphoma mimicking infectious mononucleosis and emphasizes the importance of reconsidering hematologic malignancy in patients with persistent mucocutaneous inflammation and incongruent laboratory findings.<\/jats:p>","DOI":"10.1093\/omcr\/omag048","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T12:13:35Z","timestamp":1773404015000},"source":"Crossref","is-referenced-by-count":0,"title":["Nontranslocation follicular lymphoma mimicking infectious mononucleosis: a diagnostic challenge in a 39-year-old male"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4355-8536","authenticated-orcid":false,"given":"Elinor","family":"Barsh","sequence":"first","affiliation":[{"name":"Sky Ridge Medical Center Department of Internal Medicine , 10101 RidgeGate Pkwy, Lone Tree, CO 80124 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Keeling","sequence":"additional","affiliation":[{"name":"Sky Ridge Medical Center Department of Internal Medicine , 10101 RidgeGate Pkwy, Lone Tree, CO 80124 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changlee S","family":"Pang","sequence":"additional","affiliation":[{"name":"CU Anschutz Department of Hematopathology , 12631 East 17th Avenue, Aurora, CO 80045 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross","family":"Sattler","sequence":"additional","affiliation":[{"name":"Sky Ridge Medical Center Department of Internal Medicine , 10101 RidgeGate Pkwy, Lone Tree, CO 80124 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavanya","family":"Feustel","sequence":"additional","affiliation":[{"name":"Sky Ridge Medical Center Department of Internal Medicine , 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