{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T11:46:21Z","timestamp":1782560781495,"version":"3.54.5"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lichenoid drug eruption (LDE) is an uncommon adverse reaction that can be clinically indistinguishable from idiopathic lichen planus (LP). We report a 63-year-old woman who developed a diffuse pruritic papular eruption with oral mucosal involvement two weeks after initiating letrozole for breast cancer. Histopathology revealed lichenoid interface dermatitis with scattered eosinophils extending into the deep subcutaneous tissue, supporting a drug-induced process. Due to the necessity of endocrine therapy, she was managed with high-potency topical corticosteroids and tacrolimus. Upon histologic confirmation, letrozole was replaced with exemestane, leading to a 90% improvement without recurrence. This case emphasizes the importance of clinicopathologic correlation and multidisciplinary coordination to maintain essential oncologic treatment while managing cutaneous toxicity.<\/jats:p>","DOI":"10.1093\/omcr\/omag082","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T11:49:37Z","timestamp":1776858577000},"source":"Crossref","is-referenced-by-count":0,"title":["Lichenoid drug eruption induced by letrozole: a case report"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1153-4733","authenticated-orcid":false,"given":"Yara M","family":"Alhusaini","sequence":"first","affiliation":[{"name":"Department of Dermatology, King Abdulaziz Medical City , Ministry of National Guard Health Affairs, Riyadh 11426 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulaziz A","family":"Almufadhi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, King Abdulaziz Medical City , Ministry of National Guard Health Affairs, Riyadh 11426 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayah K","family":"Sayed","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud University , Riyadh 11451 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed M","family":"Altuwaijri","sequence":"additional","affiliation":[{"name":"Department of Dermatology, King Abdulaziz Medical City , Ministry of National Guard Health Affairs, Riyadh 11426 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Shokor","sequence":"additional","affiliation":[{"name":"Department of Pathology, King Abdulaziz Medical City , Ministry of National Guard Health Affairs, Riyadh 11426 ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"2026062707163529600_ref1","doi-asserted-by":"publisher","first-page":"114","DOI":"10.5336\/dermato.2015-47331","article-title":"Letrozole-induced linear lichenoid eruption in a patient with breast cancer: case report","volume":"26","author":"\u00d6ktem","year":"2016","journal-title":"Turkiye Klinikleri J Dermatol"},{"key":"2026062707163529600_ref2","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1111\/j.1468-3083.2010.03803.x","article-title":"Aromatase inhibitor-induced skin adverse reactions: exemestane-related cutaneous vasculitis","volume":"25","author":"Santoro","year":"2011","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2026062707163529600_ref3","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s13555-020-00353-3","article-title":"Anastrozole-induced dermatitis: report of a woman with an anastrozole-associated dermatosis and a review of aromatase inhibitor-related cutaneous adverse events","volume":"10","author":"Kim","year":"2020","journal-title":"Dermatol Ther (Heidelb)"},{"key":"2026062707163529600_ref4","doi-asserted-by":"publisher","first-page":"1529342","DOI":"10.3389\/fphar.2025.1529342","article-title":"Evaluation of dermatologic adverse events associated with aromatase inhibitors: insights from the FAERS database","volume":"16","author":"Wu","year":"2025","journal-title":"Front Pharmacol"},{"key":"2026062707163529600_ref5","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1111\/jdv.18879","article-title":"Cutaneous lichenoid drug eruptions: a narrative review evaluating demographics, clinical features and culprit medications","volume":"37","author":"Maul","year":"2023","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2026062707163529600_ref6","volume-title":"Lichenoid drug eruption pathology","author":"DermNet New Zealand 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