{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T11:46:22Z","timestamp":1782560782223,"version":"3.54.5"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Angiostrongyliasis is a parasitic disease caused by Angiostrongylus costaricensis (Latin America) and A. cantonensis (Asia\/Pacific). Abdominal angiostrongyliasis often mimics appendicitis, challenging clinical diagnosis and requiring histopathological confirmation. We report a severely malnourished infant in Honduras presenting with 10\u00a0days of severe abdominal pain and vomiting, complicated by respiratory insufficiency and seizures. Brain CT revealed cortical atrophy, suggesting a chronic underlying neurologic condition. Laboratory tests showed leukocytosis, lymphocytosis, and massive eosinophilia. Exploratory laparotomy for suspected appendicitis identified an ileal perforation, requiring intestinal resection. Histopathology confirmed non-caseating granulomas containing A. costaricensis larvae within the mesenteric arteriovenous plexus, alongside scattered eggs. This is the first confirmed human case of abdominal angiostrongyliasis with suspected, unconfirmed extraintestinal involvement in the Olancho Department of Honduras. These findings emphasize the critical need for increased clinical awareness and public health measures against this overlooked parasitic infection.<\/jats:p>\n                  <jats:p>Statement of Significance This case documents the first confirmed Angiostrongylus costaricensis infection in Olancho, Honduras, presenting as intestinal perforation in an infant. For pathologists and trainees, this report underscores the diagnostic complexity of abdominal angiostrongyliasis, which frequently mimics appendicitis or Crohn\u2019s disease. It illustrates the essential morphological features for diagnosis: intense eosinophilic vasculitis, granulomatous inflammation, and the specific identification of intra-arterial larvae and eggs. Additionally, the findings suggest rare disseminated disease in the context of severe malnutrition. This report highlights the critical need to maintain a high index of suspicion for parasitic etiologies in eosinophil-rich granulomatous lesions of the gastrointestinal tract, ensuring accurate diagnosis in regions where this neglected tropical disease is underrecognized.<\/jats:p>","DOI":"10.1093\/omcr\/omag088","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:59:15Z","timestamp":1777377555000},"source":"Crossref","is-referenced-by-count":0,"title":["Intestinal perforation secondary to abdominal angiostrongyliasis in an older infant with suspected extraintestinal involvement"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6795-1398","authenticated-orcid":false,"given":"Hugo-Malik","family":"Cherif","sequence":"first","affiliation":[{"name":"Facultad de Ciencias M\u00e9dicas , , Tegucigalpa ,","place":["Honduras"]},{"name":"Universidad Nacional Aut\u00f3noma de Honduras , , Tegucigalpa ,","place":["Honduras"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Suazo","sequence":"additional","affiliation":[{"name":"Departamento de Patolog\u00eda, Hospital Escuela\/Facultad de Ciencias M\u00e9dicas , , Tegucigalpa ,","place":["Honduras"]},{"name":"Universidad Nacional Aut\u00f3noma de Honduras , , Tegucigalpa ,","place":["Honduras"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9756-4520","authenticated-orcid":false,"given":"Gustavo","family":"Fontecha","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Microbiolog\u00eda, Facultad de Ciencias , , Tegucigalpa ,","place":["Honduras"]},{"name":"Universidad Nacional Aut\u00f3noma de Honduras , , Tegucigalpa ,","place":["Honduras"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flor","family":"Gir\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Patolog\u00eda, Facultad de Ciencias M\u00e9dicas , , Tegucigalpa ,","place":["Honduras"]},{"name":"Universidad Nacional Aut\u00f3noma de Honduras , , Tegucigalpa ,","place":["Honduras"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"2026062707163845400_ref1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.5935\/0004-2749.20180014","article-title":"Intravitreal Angiostrongylus cantonensis: first case report in South America","volume":"81","author":"Andrade","year":"2018","journal-title":"Arq Bras Oftalmol"},{"key":"2026062707163845400_ref2","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.3201\/eid2306.161683","article-title":"Angiostrongylus cantonensis meningitis and myelitis, Texas, USA","volume":"23","author":"Al Hammoud","year":"2017","journal-title":"Emerg Infect Dis"},{"key":"2026062707163845400_ref3","first-page":"36","article-title":"Caracter\u00edsticas de angiostrongilosis abdominal en Honduras","volume":"2018","author":"Maradiaga","year":"2018","journal-title":"Rev Fac Cienc M\u00e9dicas"},{"key":"2026062707163845400_ref4","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1186\/s13071-023-05757-6","article-title":"A practical guide for the diagnosis of abdominal angiostrongyliasis caused by the nematode Angiostrongylus costaricensis","volume":"16","author":"Rodriguez","year":"2023","journal-title":"Parasites Vectors"},{"key":"2026062707163845400_ref5","doi-asserted-by":"publisher","first-page":"102706","DOI":"10.1016\/j.tmaid.2024.102706","article-title":"Spontaneous intestinal perforation due to a possible infection due to Angiostrongylus costaricensis in Colombia","volume":"59","author":"P\u00e9rez-Camacho","year":"2024","journal-title":"Travel Med Infect Dis"},{"key":"2026062707163845400_ref6","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1186\/s13071-021-04875-3","article-title":"Abdominal angiostrongyliasis in the Americas: fifty years since the discovery of a new metastrongylid species, Angiostrongylus costaricensis","volume":"14","author":"Rojas","year":"2021","journal-title":"Parasites Vectors"},{"key":"2026062707163845400_ref7","doi-asserted-by":"publisher","first-page":"624","DOI":"10.3390\/pathogens12040624","article-title":"Neuroangiostrongyliasis: updated provisional guidelines for diagnosis and case definitions","volume":"12","author":"Graeff-Teixeira","year":"2023","journal-title":"Pathogens"},{"key":"2026062707163845400_ref8","doi-asserted-by":"publisher","first-page":"1294484","DOI":"10.3389\/fvets.2024.1294484","article-title":"Case report: first documented case of cerebral angiostrongyliasis caused by Angiostrongylus costaricensis in a free-ranging opossum. 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