{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:18:15Z","timestamp":1791069495350,"version":"4.1.0"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute promyelocytic leukaemia (APL) is a subtype of acute myeloid leukaemia characterised by the PML\u2013RAR\u03b1 fusion gene and a high risk of early mortality if treatment is delayed. Gingival hypertrophy is an uncommon manifestation of APL and is more typically associated with monocytic and myelomonocytic AML. We report a 26-year-old male who presented with a three-week history of progressive gingival enlargement, initially managed as gingivitis for two weeks, resulting in delayed haematological evaluation. Microgranular APL was confirmed by bone marrow morphology and fluorescence in situ hybridisation, demonstrating t(15;17). Although pancytopenia was present, the absence of hyperleukocytosis or overt coagulopathy contributed to an atypical clinical picture. Due to resource constraints, all-trans retinoic acid\u2013based therapy was unavailable, and induction chemotherapy was administered, with a fatal outcome after one week. This case highlights gingival hypertrophy as an atypical early presentation and the impact of delayed diagnosis and limited access to essential therapy.<\/jats:p>","DOI":"10.1093\/omcr\/omag097","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:45:24Z","timestamp":1778154324000},"source":"Crossref","is-referenced-by-count":1,"title":["Acute promyelocytic leukaemia presenting with gingival hypertrophy: an atypical oral presentation"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0335-6861","authenticated-orcid":false,"given":"Emmanuel Kissiedu","family":"Antiri","sequence":"first","affiliation":[{"name":"Department of Haematology, Cape Coast Teaching Hospital , P.O. Box CT 1363, Cape Coast, Central Region ,","place":["Ghana"]},{"name":"Department of Haematology, University of Cape Coast School of Medical Sciences , Cape Coast, Central Region ,","place":["Ghana"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2426-314X","authenticated-orcid":false,"given":"Ivy Adwowa Efiefi","family":"Ekem","sequence":"additional","affiliation":[{"name":"Department of Haematology, University of Cape Coast School of Medical Sciences , Cape Coast, Central Region ,","place":["Ghana"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"2026062707162398700_ref1","doi-asserted-by":"publisher","first-page":"3100","DOI":"10.3324\/haematol.2021.278722","article-title":"Characteristics and outcome of patients with low\u2212\/intermediate-risk acute promyelocytic leukemia treated with arsenic trioxide: an international collaborative study","volume":"106","author":"Kayser","year":"2021","journal-title":"Haematologica."},{"key":"2026062707162398700_ref2","doi-asserted-by":"publisher","first-page":"4192","DOI":"10.3390\/cancers16244192","article-title":"Acute Promyelocytic leukemia-like AML: genetic perspective and clinical implications","volume":"16","author":"Guarnera","year":"2024","journal-title":"Cancers."},{"key":"2026062707162398700_ref3","doi-asserted-by":"publisher","first-page":"9685","DOI":"10.3390\/ijms26199685","article-title":"Regulatory role of zinc in acute Promyelocytic Leukemia: cellular and molecular aspects with therapeutic implications","volume":"26","author":"Ikegami","year":"2025","journal-title":"Int J Mol Sci"},{"key":"2026062707162398700_ref4","doi-asserted-by":"publisher","first-page":"105","DOI":"10.5603\/hcp.a2021.0009","article-title":"Acute promyelocytic leukemia: from genetic lesions identification to molecularly targeted therapy","volume":"12","author":"Majka","year":"2022","journal-title":"Deleted J"},{"key":"2026062707162398700_ref5","doi-asserted-by":"publisher","first-page":"570","DOI":"10.3324\/haematol.2021.279052","article-title":"Timely diagnosis and treatment of acute promyelocytic leukemia should be available to all","volume":"107","author":"Schuh","year":"2021","journal-title":"Haematologica."},{"key":"2026062707162398700_ref6","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.rcl.2011.05.004","article-title":"Leukemia and lymphoma","volume":"49","author":"Guillerman","year":"2011","journal-title":"Radiol Clin North Am"},{"key":"2026062707162398700_ref7","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1097\/mnm.0000000000001846","article-title":"PET\/CT in leukemia: utility and future directions","volume":"45","author":"Al-Ibraheem","year":"2024","journal-title":"Nucl Med Commun"},{"key":"2026062707162398700_ref8","doi-asserted-by":"publisher","first-page":"e2011066","DOI":"10.4084\/mjhid.2011.066","article-title":"Extramedullary disease in acute promyelocytic leukemia: two-in-one disease","volume":"3","author":"Albano","year":"2011","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"2026062707162398700_ref9","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1111\/scd.12283","article-title":"Gingival leukemic infiltration as the first manifestation of acute myeloid leukemia","volume":"38","author":"Fernandes","year":"2018","journal-title":"Spec Care Dentist"},{"key":"2026062707162398700_ref10","doi-asserted-by":"publisher","first-page":"bcr2016217457","DOI":"10.1136\/bcr-2016-217457","article-title":"Acute promyelocytic leukaemia: looking through 'gums'","volume":"2016","author":"Jain","year":"2016","journal-title":"BMJ Case Rep"},{"key":"2026062707162398700_ref11","doi-asserted-by":"publisher","first-page":"116","DOI":"10.4103\/injms.injms_26_23","article-title":"Gingival hypertrophy in acute promyelocytic leukemia \u2013 a rare clinical encounter","volume":"14","author":"Shastri","year":"2023","journal-title":"Indian J Med Specialities"},{"key":"2026062707162398700_ref12","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1182\/blood-2008-04-150250","article-title":"Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet","volume":"113","author":"Sanz","year":"2008","journal-title":"Blood."}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2026\/6\/omag097\/68529503\/omag097.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2026\/6\/omag097\/68529503\/omag097.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T11:16:29Z","timestamp":1782558989000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omag097\/8708271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,8]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omag097","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,6]]},"published":{"date-parts":[[2026,6]]},"article-number":"omag097"}}