{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T11:46:21Z","timestamp":1782560781063,"version":"3.54.5"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Rosai-Dorfman-Destombes (RDD) disease is a rare non-Langerhans cell histiocytosis typically characterized by massive lymphadenopathy. The purely cutaneous subtype (CRDD) is clinically polymorphic, mimicking various inflammatory or neoplastic conditions, making its diagnosis challenging. We present a case of a young phototype 4 Moroccan female with a 2-year history of a progressively enlarging violaceous tumor on her posterior thigh. Dermoscopy revealed structureless yellow areas with fine telangiectasias. Histological along with immunohistochemical examination showed a dense dermal infiltrate with large histiocytes exhibiting prominent emperipolesis confirming the diagnosis of CRDD. A comprehensive systemic workup was negative. No recurrence was detected after a 6\u00a0month follow up after surgical excision. This case highlights the importance of dermoscopic clues which correlates with the histological findings. In patients with higher phototypes, these findings are essential to guide the clinician toward a histiocytic disorder. Differential diagnoses such as Langerhans cell histiocytosis, juvenile xanthogranuloma, and sarcoidosis must be ruled out through immunohistopathology.<\/jats:p>","DOI":"10.1093\/omcr\/omag102","type":"journal-article","created":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T11:34:06Z","timestamp":1779622446000},"source":"Crossref","is-referenced-by-count":0,"title":["Cutaneous Rosai-Dorfman-Destombes disease: the diagnostic value of the yellow island sign"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4402-0051","authenticated-orcid":false,"given":"Maha","family":"El Maati","sequence":"first","affiliation":[{"name":"Dermatology Department, Ibn Sina University Hospital, Mohammed V University , United Nations Avenue, Rabat 10000 ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima Zahra","family":"Sassine","sequence":"additional","affiliation":[{"name":"Dermatology Department, Ibn Sina University Hospital, Mohammed V University , United Nations Avenue, Rabat 10000 ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouna","family":"Rimani","sequence":"additional","affiliation":[{"name":"Pathology Department, 6 Derna street, Center of Hassan , Rabat 10020 ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Benzekri","sequence":"additional","affiliation":[{"name":"Dermatology Department, Ibn Sina University Hospital, Mohammed V University , United Nations Avenue, Rabat 10000 ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Ismaili","sequence":"additional","affiliation":[{"name":"Dermatology Department, Ibn Sina University Hospital, Mohammed V University , United Nations Avenue, Rabat 10000 ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,21]]},"reference":[{"key":"2026062707163455900_ref1","doi-asserted-by":"publisher","first-page":"2877","DOI":"10.1182\/blood-2018-03-839753","article-title":"Consensus recommendations for the diagnosis and clinical management of Rosai-Dorfman-Destombes disease","volume":"131","author":"Abla","year":"2018","journal-title":"Blood."},{"key":"2026062707163455900_ref2","doi-asserted-by":"publisher","first-page":"A139","DOI":"10.1016\/j.revmed.2023.04.031","article-title":"La maladie de Rosai Dorfman cutan\u00e9e: Une entit\u00e9 rare \u00e0 ne pas m\u00e9conna\u00eetre, \u00e0 propos de trois cas","volume":"44","author":"Massaoudi","year":"2023","journal-title":"Rev Med Interne"},{"key":"2026062707163455900_ref3","doi-asserted-by":"publisher","first-page":"6540","DOI":"10.1182\/blood-2025-6540","article-title":"Epidemiology and outcomes of rosai-dorfman-destombes disease (RDD): a ten year single-center real world experience","volume":"146","author":"Gandler","year":"2025","journal-title":"Blood."},{"key":"2026062707163455900_ref4","doi-asserted-by":"publisher","first-page":"S287","DOI":"10.5021\/ad.22.071","article-title":"Facial cutaneous Rosai-Dorfman disease: Dermoscopic findings with successful surgical treatment","volume":"35","author":"Hur","year":"2023","journal-title":"Ann Dermatol"},{"key":"2026062707163455900_ref5","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.ad.2011.07.019","article-title":"Caracter\u00edsticas dermatosc\u00f3picas de la enfermedad de Rosai-Dorfman cut\u00e1nea [Dermoscopic features of cutaneous Rosai-Dorfman disease]","volume":"103","author":"Avil\u00e9s-Izquierdo","year":"2012","journal-title":"Actas Dermosifiliogr"},{"key":"2026062707163455900_ref6","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1136\/jclinpath-2020-206733","article-title":"Rosai-Dorfman disease: an overview","volume":"73","author":"Bruce-Brand","year":"2020","journal-title":"J Clin Pathol"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2026\/6\/omag102\/68566875\/omag102.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2026\/6\/omag102\/68566875\/omag102.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T11:16:40Z","timestamp":1782559000000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omag102\/8712682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":6,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,8]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omag102","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,6]]},"published":{"date-parts":[[2026,6]]},"article-number":"omag102"}}