{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T15:02:43Z","timestamp":1785164563336,"version":"3.55.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Takotsubo cardiomyopathy (TCM) is characterized by transient regional systolic dysfunction without obstructive coronary artery disease. A rare subtype, happy heart syndrome (HHS), is triggered by positive emotional events. A 65-year-old woman with hypertension, diabetes mellitus, and dyslipidemia presented with typical anginal chest pain for three days, beginning after attending a wedding party. Initial clinic ECG showed anterolateral ST-segment elevation, prompting referral to the Emergency Department. On arrival, her chest pain had resolved, and repeated ECG demonstrated normalization of ST changes with QT prolongation and T-wave inversion. Troponin was elevated at 717\u00a0ng\/l. Echocardiography showed an EF of 35% (baseline 58%) with apical and LAD-territory akinesia and ballooning. Coronary angiography revealed normal coronaries, while left ventricular angiography demonstrated findings consistent with TCM. Cardiac MRI excluded infarction or fibrosis. With guideline-directed therapy, EF recovered to 56% on follow-up.<\/jats:p>","DOI":"10.1093\/omcr\/omag108","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T13:53:14Z","timestamp":1783518794000},"source":"Crossref","is-referenced-by-count":0,"title":["An unexpected sequel to happiness: happy heart syndrome"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7431-5191","authenticated-orcid":false,"given":"Laith","family":"Rhabneh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hackensack Meridian Ocean University Medical Center , Brick Township, NJ 08724 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7531-0232","authenticated-orcid":false,"given":"Jamil","family":"Wafi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hamad Medical Corporation , Doha ,","place":["Qatar"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2073-6619","authenticated-orcid":false,"given":"Ra\u2019ed","family":"Ababneh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hackensack Meridian Ocean University Medical Center , Brick Township, NJ 08724 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1731-625X","authenticated-orcid":false,"given":"Shahd","family":"Qaddour","sequence":"additional","affiliation":[{"name":"Diagnostic Radiology Department, King Abdullah University Hospital , Irbid, 22110 ,","place":["Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2260-4289","authenticated-orcid":false,"given":"Mohammed","family":"Aloqaily","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, University of Maryland Midtown Campus , Baltimore, MD 21201 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8690-155X","authenticated-orcid":false,"given":"Abdel Rahman","family":"Alwardat","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, King Abdullah University Hospital , Ramtha, Irbid, 22110 ,","place":["Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0606-9797","authenticated-orcid":false,"given":"Khalid","family":"Hazaimeh","sequence":"additional","affiliation":[{"name":"Jordan Ministry of Health , Amman, 11118 ,","place":["Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"2026072710482562600_ref1","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.ahj.2007.11.008","article-title":"Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction","volume":"155","author":"Prasad","year":"2008","journal-title":"Am Heart J"},{"key":"2026072710482562600_ref2","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1056\/NEJMoa1406761","article-title":"Clinical features and outcomes of Takotsubo (stress) cardiomyopathy","volume":"373","author":"Templin","year":"2015","journal-title":"N Engl J Med"},{"key":"2026072710482562600_ref3","first-page":"441","article-title":"Takotsubo (stress) cardiomyopathy","volume":"6","author":"Sharkey","year":"2010","journal-title":"Heart Fail Clin"},{"key":"2026072710482562600_ref4","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1093\/eurheartj\/ehy076","article-title":"International expert consensus document on Takotsubo syndrome (part I): clinical characteristics, diagnostic criteria, and pathophysiology","volume":"39","author":"Ghadri","year":"2018","journal-title":"Eur Heart J"},{"key":"2026072710482562600_ref5","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1093\/eurheartj\/ehv757","article-title":"Happy heart syndrome: role of positive emotional stress in Takotsubo syndrome","volume":"37","author":"Ghadri","year":"2016","journal-title":"Eur Heart J"},{"key":"2026072710482562600_ref6","first-page":"603","article-title":"Prevalence and clinical profile of patients with apical ballooning syndrome (Takotsubo\/stress cardiomyopathy) at a tertiary care center","volume":"99","author":"Elesber","year":"2007","journal-title":"Am J Cardiol"},{"key":"2026072710482562600_ref7","first-page":"669","article-title":"Takotsubo syndrome (stress cardiomyopathy): an intriguing clinical condition in search of its identity","volume":"130","author":"Pelliccia","year":"2017","journal-title":"Am J Med"},{"key":"2026072710482562600_ref8","first-page":"874","article-title":"Prevalence and clinical characteristics of atypical Takotsubo syndrome: multicenter experience","volume":"17","author":"Citro","year":"2015","journal-title":"Eur J Heart Fail"},{"key":"2026072710482562600_ref9","volume-title":"Takotsubo Syndrome","author":"American College of Cardiology","year":"2020"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2026\/7\/omag108\/68718845\/omag108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2026\/7\/omag108\/68718845\/omag108.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:48:36Z","timestamp":1785163716000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omag108\/8728303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":9,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7,8]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omag108","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,7]]},"article-number":"omag108"}}