{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T15:02:59Z","timestamp":1785164579912,"version":"3.55.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Psychiatric-onset dementia with Lewy bodies (poDLB) is a recognised but poorly characterised prodromal phenotype. The existing literature focuses almost entirely on de novo psychiatric presentations; decompensation of pre-existing primary psychiatric illness as a manifestation of poDLB has not previously been described. We present a case of a patient with a near-lifelong history of severe obsessive compulsive disorder (OCD), decompensation of which in her early 70s was later recognised as a harbinger of dementia with Lewy bodies (DLB). Escalating OCD symptoms, emergent parkinsonism, and cognitive fluctuations culminated in a probable DLB diagnosis within one year of psychiatric presentation, supported by significantly abnormal dopamine transporter imaging. Recognising decompensation of longstanding primary psychiatric illness as a potential manifestation of poDLB has important implications for timely diagnosis, safe prescribing (particularly neuroleptics) and early biomarker-driven referral.<\/jats:p>","DOI":"10.1093\/omcr\/omag115","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T13:52:13Z","timestamp":1783518733000},"source":"Crossref","is-referenced-by-count":0,"title":["Late-life decompensation in longstanding obsessive compulsive disorder: a psychiatric prodrome of dementia with Lewy bodies? A case report"],"prefix":"10.1093","volume":"2026","author":[{"given":"R E","family":"Agnew","sequence":"first","affiliation":[{"name":"Southern Health and Social Care Trust , 68 Lurgan Rd, Portadown, Craigavon BT63 5QQ, Northern Ireland (NI) ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Garcia","sequence":"additional","affiliation":[{"name":"Belfast Health and Social Care Trust , Royal Victoria Hospital, 274 Grosvenor Road, Belfast, BT12 6BA, NI ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Barton","sequence":"additional","affiliation":[{"name":"Belfast Health and Social Care Trust , Royal Victoria Hospital, 274 Grosvenor Road, Belfast, BT12 6BA, NI ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Kearney","sequence":"additional","affiliation":[{"name":"Belfast Health and Social Care Trust , Royal Victoria Hospital, 274 Grosvenor Road, Belfast, BT12 6BA, NI ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8479-9977","authenticated-orcid":false,"given":"J P M","family":"Kane","sequence":"additional","affiliation":[{"name":"Belfast Health and Social Care Trust , Royal Victoria Hospital, 274 Grosvenor Road, Belfast, BT12 6BA, NI ,","place":["United Kingdom"]},{"name":"Centre for Public Health, Queen\u2019s University Belfast , Institute of Clinical Sciences B, Royal Victoria Hospital, Belfast, BT12 6BA, NI ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"2026072710482889100_ref1","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1212\/WNL.0000000000004058","article-title":"Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB 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