{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T15:03:41Z","timestamp":1785164621532,"version":"3.55.0"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 66-year-old woman presented with right bloody nipple discharge (BND). Initial evaluation, including palpation, mammography (MMG), ultrasonography (US), and cytology, revealed no abnormalities. In the second year, persistent BND prompted breast magnetic resonance imaging (MRI), which demonstrated non-mass enhancement in the lower right breast and was classified as Breast Imaging Reporting and Data System (BI-RADS) category 3; therefore, imaging surveillance was performed. In the third year, cytological examination revealed atypical cells. Repeat MRI again demonstrated non-mass enhancement. US\/MRI fusion identified two suspicious regions; however, ultrasound-guided needle biopsy showed no evidence of malignancy. Because of persistent BND and cytological atypia, excisional biopsy was performed, and ductal carcinoma in situ (DCIS) was confirmed. US\/MRI fusion may assist in localizing target areas for biopsy in patients with MRI-detected lesions without corresponding findings on MMG or US; however, histopathological confirmation remains essential.<\/jats:p>","DOI":"10.1093\/omcr\/omag119","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T13:52:11Z","timestamp":1783518731000},"source":"Crossref","is-referenced-by-count":0,"title":["Detection of occult non-mass enhancement in bloody nipple discharge using US\/MRI fusion imaging: a case report"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1352-003X","authenticated-orcid":false,"given":"Yukako","family":"Mouri","sequence":"first","affiliation":[{"name":"Department of Breast and Endocrine Surgery, Aichi Medical University , 1-1 Yazakokarimata, Nagakute, Aichi 480-1195,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5279-8167","authenticated-orcid":false,"given":"Masayuki","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery, Aichi Medical University , 1-1 Yazakokarimata, Nagakute, Aichi 480-1195,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanna","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery, Aichi Medical University , 1-1 Yazakokarimata, Nagakute, Aichi 480-1195,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirona","family":"Banno","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery, Aichi Medical University , 1-1 Yazakokarimata, Nagakute, Aichi 480-1195,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manami","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery, Aichi Medical University , 1-1 Yazakokarimata, Nagakute, Aichi 480-1195,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirai","family":"Ido","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery, Aichi Medical University , 1-1 Yazakokarimata, Nagakute, Aichi 480-1195,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahito","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery, Aichi Medical University , 1-1 Yazakokarimata, Nagakute, Aichi 480-1195,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Kousaka","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery, Aichi Medical University , 1-1 Yazakokarimata, Nagakute, Aichi 480-1195,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimihito","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery, Aichi Medical University , 1-1 Yazakokarimata, Nagakute, Aichi 480-1195,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuneo","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery, Aichi Medical University , 1-1 Yazakokarimata, Nagakute, Aichi 480-1195,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery, Aichi Medical University , 1-1 Yazakokarimata, Nagakute, Aichi 480-1195,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology, Aichi Medical University ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiko","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology, Aichi Medical University ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koujiro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Radiology, Aichi Medical University ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"2026072710484000300_ref1","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1007\/s00330-010-2009-y","article-title":"Magnetic resonance imaging in patients with nipple discharge: should we recommend it?","volume":"21","author":"Lorenzon","year":"2011","journal-title":"Eur Radiol"},{"key":"2026072710484000300_ref2","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1308\/RCSANN.2020.0036","article-title":"The investigation and management of unilateral nipple discharge","volume":"102","author":"Clark","year":"2020","journal-title":"Ann R Coll Surg Engl"},{"key":"2026072710484000300_ref3","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ejrad.2004.11.019","article-title":"Mammography of ductal carcinoma in situ of the breast: review of 909 cases with radiographic-pathologic correlations","volume":"54","author":"Barreau","year":"2005","journal-title":"Eur J Radiol"},{"key":"2026072710484000300_ref4","doi-asserted-by":"publisher","first-page":"e27","DOI":"10.1016\/j.crad.2012.09.003","article-title":"Screening-detected calcified and non-calcified ductal carcinoma in situ: differences in the imaging and histopathological features","volume":"68","author":"Mun","year":"2013","journal-title":"Clin Radiol"},{"key":"2026072710484000300_ref5","doi-asserted-by":"publisher","first-page":"34","DOI":"10.25259\/JCIS_48_2021","article-title":"Imaging of noncalcified ductal carcinoma in situ","volume":"11","author":"Bragg","year":"2021","journal-title":"J Clin Imaging Sci"},{"key":"2026072710484000300_ref6","doi-asserted-by":"publisher","first-page":"20180464","DOI":"10.1259\/bjr.20180464","article-title":"The MRI characteristics of non-mass enhancement lesions of the breast: associations with malignancy","volume":"92","author":"Aydin","year":"2019","journal-title":"Br J Radiol"},{"key":"2026072710484000300_ref7","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s10396-021-01175-2","article-title":"Evaluation of an MRI\/US fusion technique for the detection of non-mass enhancement of breast lesions detected by MRI yet occult on conventional B-mode second-look US","volume":"49","author":"Goto","year":"2001","journal-title":"J Med Ultrason"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2026\/7\/omag119\/68718866\/omag119.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2026\/7\/omag119\/68718866\/omag119.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:48:48Z","timestamp":1785163728000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omag119\/8728298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":7,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7,8]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omag119","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,7]]},"article-number":"omag119"}}