{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T15:02:51Z","timestamp":1785164571011,"version":"3.55.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>VEXAS syndrome is a recently identified adult-onset autoinflammatory disorder caused by somatic mutations in the UBA1 gene, leading to systematic inflammation and hematological dysfunctions. We present the case of a 71-year-old man with a prolonged history of cutaneous lesions and inflammatory arthritis that is refractory. Despite the treatment with multiple immunosuppressive therapies, his symptoms persisted alongside macrocytic anemia and thrombocytopenia. Genetic testing confirmed a UBA1 mutation, which established the diagnosis of VEXAS syndrome. A subsequent bone marrow biopsy revealed myelodysplastic syndrome. This case highlights the importance of early recognition of VEXAS syndrome, particularly in patients with multisystemic involvement and treatment-refractory disease. Therapies such as JAK inhibitors may provide effective disease control in patients who are not candidates for hematopoietic stem cell transplantation.<\/jats:p>","DOI":"10.1093\/omcr\/omag121","type":"journal-article","created":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T22:44:32Z","timestamp":1783896272000},"source":"Crossref","is-referenced-by-count":0,"title":["VEXAS syndrome presenting with severe cutaneous manifestations, inflammatory arthritis, and myelodysplastic syndrome treated with Ruxolitinib"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5715-2013","authenticated-orcid":false,"given":"Jared","family":"Tesch","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, North Dakota State University , 1340 Bolley Drive, Fargo, ND 58102,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Alrifai","sequence":"additional","affiliation":[{"name":"Division of Rheumatic and Autoimmune Diseases, M Health Fairview Clinics and Surgery Center, Department of Medicine, University of Minnesota , 606 24th Avenue South, Suite 200, Minneapolis, MN 55454,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Honl","sequence":"additional","affiliation":[{"name":"Dermatology Service, Veterans Affairs Health Care Systems , 2101 Elm St NE, Fargo, ND 58102,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth","family":"Singhal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Veterans Affairs Health Care Systems , 2101 Elm St NE, Fargo, ND 58102,","place":["United States"]},{"name":"Department of Medicine, University of North Dakota School of Medicine and Health Sciences , 1301 N Columbia Rd, Grand Forks, ND 58203,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,12]]},"reference":[{"key":"2026072710482085400_ref1","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.1056\/NEJMoa2026834","article-title":"Somatic mutations in UBA1 and severe adult-onset autoinflammatory disease","volume":"383","author":"Beck","year":"2020","journal-title":"N Engl J Med"},{"key":"2026072710482085400_ref2","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.jdcr.2021.06.010","article-title":"Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome\u2014clinical presentation of a newly described somatic, autoinflammatory syndrome","volume":"14","author":"Alhomida","year":"2021","journal-title":"JAAD Case Rep"},{"key":"2026072710482085400_ref3","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1111\/ijd.16635","article-title":"Cutaneous involvement in VEXAS syndrome: clinical and histopathologic findings","volume":"62","author":"Hines","year":"2023","journal-title":"Int J Dermatol"},{"key":"2026072710482085400_ref4","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1111\/bjd.20805","article-title":"Further characterization of clinical and laboratory features in VEXAS syndrome: large-scale analysis of a multicentre case series of 116 French patients","volume":"186","author":"Georgin-Lavialle","year":"2022","journal-title":"Br J Dermatol"},{"key":"2026072710482085400_ref5","doi-asserted-by":"publisher","first-page":"5217","DOI":"10.1093\/rheumatology\/keaf293","article-title":"Clinical features in VEXAS syndrome: a systematic review","volume":"64","author":"Al-Hakim","year":"2025","journal-title":"Rheumatology (Oxford)"},{"key":"2026072710482085400_ref6","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1007\/s10875-025-01932-9","article-title":"Diagnostic and monitoring strategies for VEXAS syndrome: evaluating sanger sequencing, NGS, and the SWIM-score","volume":"45","author":"Von Bornemann","year":"2025","journal-title":"J Clin Immunol"},{"key":"2026072710482085400_ref7","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1177\/15353702231165030","article-title":"JAK inhibitors for the treatment of VEXAS syndrome","volume":"248","author":"Bindoli","year":"2023","journal-title":"Exp Biol Med (Maywood)"},{"key":"2026072710482085400_ref8","doi-asserted-by":"publisher","first-page":"3565","DOI":"10.1007\/s10067-024-07160-7","article-title":"Allogenic haematopoietic stem cell transplantation in VEXAS: a review of 33 patients","volume":"43","author":"Ali","year":"2024","journal-title":"Clin Rheumatol"},{"key":"2026072710482085400_ref9","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1053\/j.seminhematol.2021.09.001","article-title":"Toward a pathophysiology inspired treatment of VEXAS syndrome","volume":"58","author":"Heiblig","year":"2021","journal-title":"Semin Hematol"}],"container-title":["Oxford Medical 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