{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:19:08Z","timestamp":1790983148891,"version":"4.1.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Daptomycin is an effective antibiotic for resistant gram-positive infections, including MRSA and VRE, but can rarely cause daptomycin-induced eosinophilic pneumonia (DIEP). We present a 73-year-old woman treated for prosthetic joint infection who developed acute hypoxemic respiratory failure and peripheral eosinophilia after 21\u00a0days of daptomycin therapy. Chest imaging showed bilateral upper lobe consolidations. Symptoms resolved rapidly after stopping daptomycin, without corticosteroid use. This case highlights the need for early recognition of DIEP in patients presenting with new respiratory symptoms and eosinophilia during daptomycin therapy, enabling timely discontinuation and reducing potential morbidity.<\/jats:p>","DOI":"10.1093\/omcr\/omag146","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:19:47Z","timestamp":1785323987000},"source":"Crossref","is-referenced-by-count":1,"title":["The double-edged sword of daptomycin: a case of daptomycin-induced eosinophilic pneumonia"],"prefix":"10.1093","volume":"2026","author":[{"given":"Mohammed Najdat","family":"Seijari","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Good Samaritan Hospital, TriHealth , 375 Dixmyth Ave, Mount Auburn neighborhood, Cincinnati, OH 45220 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fayaz","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Good Samaritan Hospital, TriHealth , 375 Dixmyth Ave, Mount Auburn neighborhood, Cincinnati, OH 45220 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taraneh","family":"Zamani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Good Samaritan Hospital, TriHealth , 375 Dixmyth Ave, Mount Auburn neighborhood, Cincinnati, OH 45220 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahla","family":"Mallick","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Good Samaritan Hospital, TriHealth , 375 Dixmyth Ave, Mount Auburn, Cincinnati, OH 45220 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6189-2784","authenticated-orcid":false,"given":"Mohammad Nasser","family":"Affas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hamad Medical Corporation , Al Rayyan Road, Hamad Medical City, Doha ,","place":["Qatar"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Beerman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Good Samaritan Hospital, TriHealth , 375 Dixmyth Ave, Mount Auburn neighborhood, Cincinnati, OH 45220 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"2026082207314831100_ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jac\/dkx349","article-title":"Daptomycin","volume":"73","author":"Heidary","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"2026082207314831100_ref2","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1186\/s12879-017-2842-6","article-title":"Daptomycin treatment in patients with resistant staphylococcal periprosthetic joint infection","volume":"17","author":"Chang","year":"2017","journal-title":"BMC Infect Dis"},{"key":"2026082207314831100_ref3","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1093\/jac\/dkae026","article-title":"Comparison of daptomycin and glycopeptide efficacy and safety","volume":"79","author":"Boulekbache","year":"2024","journal-title":"J Antimicrob Chemother"},{"key":"2026082207314831100_ref4","doi-asserted-by":"publisher","first-page":"12","DOI":"10.24926\/iip.v15i2.6200","article-title":"Diagnosis and Management of Daptomycin-Induced Acute Eosinophilic Pneumonia: A case report","volume":"15","author":"Elbarbry","year":"2024","journal-title":"Innovations in Pharmacy"},{"key":"2026082207314831100_ref5","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s13756-016-0158-8","article-title":"Daptomycin-induced eosinophilic pneumonia: A systematic review","volume":"5","author":"Uppal","year":"2016","journal-title":"Antimicrob Resist Infect Control"},{"key":"2026082207314831100_ref6","doi-asserted-by":"publisher","first-page":"446","DOI":"10.3390\/antibiotics10040446","article-title":"Risk factors of daptomycin-induced eosinophilic pneumonia","volume":"10","author":"Soldevila-Boixader","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"2026082207314831100_ref7","doi-asserted-by":"publisher","first-page":"447","DOI":"10.2165\/11597460-000000000-00000","article-title":"Eosinophilic pneumonia in patients treated with daptomycin","volume":"35","author":"Kim","year":"2012","journal-title":"Drug Saf"},{"key":"2026082207314831100_ref8","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1007\/s15010-024-02349-z","article-title":"Daptomycin eosinophilic pneumonia: Systematic review and case series","volume":"52","author":"Gidari","year":"2024","journal-title":"Infection"},{"key":"2026082207314831100_ref9","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1016\/0091-6749(94)90333-6","article-title":"The effects of glucocorticoids on human eosinophils","volume":"94","author":"Schleimer","year":"1994","journal-title":"J Allergy Clin Immunol"},{"key":"2026082207314831100_ref10","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.medcli.2022.03.017","article-title":"Clinical characteristics and outcomes of eosinophilic pneumonia associated with daptomycin","volume":"160","author":"Wu","year":"2023","journal-title":"Med Clin (Barc)"},{"key":"2026082207314831100_ref11","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1159\/000535190","article-title":"Daptomycin-induced eosinophilic pneumonia: Case report and systematic review","volume":"69","author":"Di Lorenzo","year":"2024","journal-title":"Chemotherapy"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2026\/8\/omag146\/70611039\/omag146.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2026\/8\/omag146\/70611039\/omag146.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T11:31:53Z","timestamp":1787398313000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omag146\/8758936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":11,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8,3]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omag146","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8]]},"published":{"date-parts":[[2026,8]]},"article-number":"omag146"}}