{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:15:26Z","timestamp":1788380126465,"version":"build-2803163510"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute for Health Research Nottingham Biomedical Research Centre","award":["NIHR203310"],"award-info":[{"award-number":["NIHR203310"]}]},{"name":"Legacy of Norton and Anne Collier"},{"name":"Chris Brownbridge Trust"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We retrospectively reviewed histopathological and immunohistochemical data from patients with mixed exocrine-neuroendocrine intraductal papillary mucinous neoplasms (IPMNs) of the pancreas identified at a single centre between December 2023 and June 2026. Surgical specimens underwent detailed evaluation, including mucin profiling (MUC1, MUC2, MUC5AC) and neuroendocrine markers (synaptophysin, chromogranin A). Ten patients (median age 68.5\u00a0years, range: 31\u201378\u00a0years; 6 male) presented mainly with abdominal pain, weight loss, or jaundice. Most lesions were intestinal type IPMNs with focal or interspersed neuroendocrine components. Mucin expression patterns aligned with established subtype profiles, and neuroendocrine differentiation was confirmed immunohistochemically. Only one of the lesions met the World Health Organization (WHO) criteria for mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) due to the non-invasive IPMN component. This case series highlights a distinct subset of mixed non-invasive IPMN-neuroendocrine tumours not currently recognized in WHO classifications. We propose recognition of this entity to improve diagnostic precision and guide management.<\/jats:p>","DOI":"10.1093\/omcr\/omag147","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:49:26Z","timestamp":1787312966000},"source":"Crossref","is-referenced-by-count":0,"title":["Mixed exocrine-neuroendocrine intraductal papillary mucinous neoplasms of the pancreas: a case series"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3568-4934","authenticated-orcid":false,"given":"Jaimin P","family":"Chauhan","sequence":"first","affiliation":[{"name":"University of Nottingham Medical School , Nottingham University Hospitals NHS Trust, Queen\u2019s Medical Centre, Derby Road, Nottingham NG7 2UH , Nottinghamshire,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4622-4848","authenticated-orcid":false,"given":"Aryan K","family":"Sharma","sequence":"additional","affiliation":[{"name":"University of Nottingham Medical School , Nottingham University Hospitals NHS Trust, Queen\u2019s Medical Centre, Derby Road, Nottingham NG7 2UH , Nottinghamshire,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3351-6460","authenticated-orcid":false,"given":"Abed M","family":"Zaitoun","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology, Nottingham University Hospitals NHS Trust, Queen\u2019s Medical Centre , Derby Road, Nottingham NG7 2UH , Nottinghamshire,","place":["United Kingdom"]},{"name":"Nottingham Digestive Diseases Centre, Division of Translational Medical Sciences, School of Medicine, University of Nottingham, Queen\u2019s Medical Centre , Derby Road, Nottingham NG7 2UH , Nottinghamshire,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1187-5796","authenticated-orcid":false,"given":"Dileep N","family":"Lobo","sequence":"additional","affiliation":[{"name":"Nottingham Digestive Diseases Centre, Division of Translational Medical Sciences, School of Medicine, University of Nottingham, Queen\u2019s Medical Centre , Derby Road, Nottingham NG7 2UH , Nottinghamshire,","place":["United Kingdom"]},{"name":"Department of Surgery, Nottingham University Hospitals NHS Trust, Queen\u2019s Medical Centre , Derby Road, Nottingham NG7 2UH , Nottinghamshire,","place":["United Kingdom"]},{"name":"National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen\u2019s Medical Centre , Derby Road, Nottingham NG7 2UH , Nottinghamshire,","place":["United Kingdom"]},{"name":"MRC Versus Arthritis Centre for Musculoskeletal Ageing Research, School of Life Sciences, University of Nottingham, Queen\u2019s Medical Centre , Derby Road, Nottingham NG7 2UH , Nottinghamshire,","place":["United Kingdom"]},{"name":"Division of Surgery, Perelman School of Medicine, University of Pennsylvania , Spruce Street, Philadelphia 19104, PA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"2026090215274666500_ref1","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s00428-021-03211-5","article-title":"Neuroendocrine neoplasms of the pancreas: Ddiagnosis and pitfalls","volume":"480","author":"Konukiewitz","year":"2022","journal-title":"Virchows Arch"},{"key":"2026090215274666500_ref2","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1038\/ajg.2018.14","article-title":"ACG clinical guideline: diagnosis and management of pancreatic cysts","volume":"113","author":"Elta","year":"2018","journal-title":"Am J 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