{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T12:22:45Z","timestamp":1787401365156,"version":"build-2736575974"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Primary small cell neuroendocrine carcinoma (SCNC) of the bladder is an exceptionally aggressive malignancy. We report the case of an 80-year-old male, a chronic smoker, presenting with an 8-month history of intermittent total hematuria. Cystoscopy revealed a 72\u00a0mm mass infiltrating the bladder dome, posterior, and lateral walls. Histopathological analysis of transurethral resection specimens demonstrated a necrotic diffuse proliferation of monomorphic small cells infiltrating the muscularis propria. Immunohistochemistry showed positivity for synaptophysin, chromogranin A, CD56, and TTF1, whereas GATA3 and p63 were negative. The Ki-67 index exceeded 90%. Systemic staging (cT3bN0M0) confirmed the primary bladder origin. Although multimodal management, including neoadjuvant chemotherapy and radical cystoprostatectomy, was recommended, the patient-initiated chemotherapy but declined surgery. Primary bladder SCNC is a highly invasive entity requiring early diagnosis and multidisciplinary care. The diagnosis is strictly anatomopathological. Differentiating this entity from primary pulmonary small cell carcinoma is a critical challenge, making systemic radiological staging mandatory.<\/jats:p>","DOI":"10.1093\/omcr\/omag156","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:43:17Z","timestamp":1785843797000},"source":"Crossref","is-referenced-by-count":0,"title":["Primary small-cell neuroendocrine carcinoma of the bladder: a very rare histological subtype"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6016-5005","authenticated-orcid":false,"given":"Siham","family":"Mesmoudi","sequence":"first","affiliation":[{"name":"Department of Pathology, Ibn Sina Teaching Hospital , Rue Al Mfaddal Cherkaoui, Rabat 10170 ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Mohammed","family":"Miko","sequence":"additional","affiliation":[{"name":"Urology Department CHU Ibn Sina, Mohamed V University, Rue Lamfadel Cherkaoui in Rabat ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma","family":"bencheikh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ibn Sina Teaching Hospital , Rue Al Mfaddal Cherkaoui, Rabat 10170 ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4205-8051","authenticated-orcid":false,"given":"Taha Yassine","family":"Aaboudech","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ibn Sina Teaching Hospital , Rue Al Mfaddal Cherkaoui, Rabat 10170 ,","place":["Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8935-1346","authenticated-orcid":false,"given":"Sabrine","family":"Derqaoui","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ibn Sina Teaching Hospital , Rue Al Mfaddal Cherkaoui, Rabat 10170 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