{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T12:22:43Z","timestamp":1787401363608,"version":"build-2736575974"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A man in his 40s presented with mildly elevated alpha-fetoprotein (AFP) levels during routine screening. Initial evaluation, including abdominal ultrasonography, revealed no intrahepatic mass, and the patient was placed under surveillance. Approximately 20\u00a0months later, AFP and PIVKA-II levels increased to &amp;gt;\u2009200\u2009000\u00a0ng\/mL and 1524 mAU\/mL, respectively. Contrast-enhanced computed tomography (CT) demonstrated diffusely enhancing peritoneal nodules with ascites; however, no definite intrahepatic tumor was detected. Diagnostic laparoscopy revealed multiple soft, reddish-brown nodules involving the peritoneum, omentum, and mesentery. Histopathological examination with immunohistochemistry confirmed disseminated hepatocellular carcinoma (HCC). Retrospective image review identified a small hypervascular nodule with washout extending from the left lateral liver segment toward the left triangular ligament, consistent with a pedunculated extrahepatic HCC. Despite treatment, the patient died 14\u00a0months after diagnostic laparoscopy. This case demonstrates that extrahepatically growing HCC may initially present with peritoneal dissemination, even in the absence of an apparent intrahepatic mass.<\/jats:p>","DOI":"10.1093\/omcr\/omag157","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:43:15Z","timestamp":1785843795000},"source":"Crossref","is-referenced-by-count":0,"title":["Extrahepatically growing hepatocellular carcinoma diagnosed after presentation with peritoneal dissemination: a case report"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6417-0276","authenticated-orcid":false,"given":"Kosuke","family":"Isomura","sequence":"first","affiliation":[{"name":"Department of Gastroenterological and General Surgery, St. Marianna University School of Medicine , 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7469-7053","authenticated-orcid":false,"given":"Keisuke","family":"Ida","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and General Surgery, St. Marianna University School of Medicine , 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Machi","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and General Surgery, St. Marianna University School of Medicine , 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinjiro","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and General Surgery, St. Marianna University School of Medicine , 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Koizumi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and General Surgery, St. Marianna University School of Medicine , 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2665-1317","authenticated-orcid":false,"given":"Shinya","family":"Mikami","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and General Surgery, St. Marianna University School of Medicine , 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,22]]},"reference":[{"key":"2026082207313441600_ref1","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1002\/1097-0142(19830215)51:4&lt;746::AID-CNCR2820510433&gt;3.0.CO;2-#","article-title":"Pedunculated hepatocellular carcinoma. Report of three cases and review of literature","volume":"51","author":"Horie","year":"1983","journal-title":"Cancer"},{"key":"2026082207313441600_ref2","doi-asserted-by":"publisher","first-page":"806","DOI":"10.2957\/kanzo.25.806","article-title":"Six cases of extrahepatic growing hepatocellular carcinoma: clinicopathological classification and surgical therapy","volume":"25","author":"Ichikawa","year":"1984","journal-title":"Kanzo"},{"key":"2026082207313441600_ref3","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1148\/radiology.216.3.r00se24698","article-title":"Extrahepatic metastases of hepatocellular carcinoma","volume":"216","author":"Katyal","year":"2000","journal-title":"Radiology"},{"key":"2026082207313441600_ref4","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s005340070060","article-title":"Extrahepatic large hepatocellular carcinoma with peritoneal dissemination: multimodal treatment, including four surgical operations","volume":"7","author":"Tanaka","year":"2000","journal-title":"J Hepato-Biliary-Pancreat Surg"},{"key":"2026082207313441600_ref5","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s005350200089","article-title":"A 5-year survivor after resection of peritoneal metastases from pedunculated-type hepatocellular carcinoma","volume":"37","author":"Kurachi","year":"2002","journal-title":"J Gastroenterol"},{"key":"2026082207313441600_ref6","first-page":"27","article-title":"Ectopic liver","volume":"67","author":"Collan","year":"1978","journal-title":"Ann Chir Gynaecol"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2026\/8\/omag157\/70762765\/omag157.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2026\/8\/omag157\/70762765\/omag157.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T11:31:37Z","timestamp":1787398297000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omag157\/8768544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":6,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8,3]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omag157","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8]]},"published":{"date-parts":[[2026,8]]},"article-number":"omag157"}}