{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:08:11Z","timestamp":1789416491905,"version":"build-2803163510"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sevelamer carbonate, a non-calcium phosphate binder widely used in end-stage renal disease (ESRD), is an increasingly recognized but underdiagnosed cause of medication-induced colitis through gastrointestinal crystal deposition. We report a 56-year-old Palestinian male with ESRD on hemodialysis who presented with a one-month history of watery non-bloody diarrhea, vomiting, and diffuse abdominal pain. He had been repeatedly misdiagnosed with amebic colitis and treated with metronidazole without improvement. Colonoscopy revealed diffuse patchy erythema throughout the colon with right-sided predominance. Histopathology confirmed sevelamer-induced active colitis, demonstrating characteristic brownish fish scale-like crystals with active neutrophilic infiltrate. Sevelamer carbonate was discontinued with subsequent clinical improvement. This case highlights a clinically important diagnostic pitfall in resource-limited settings where amebic colitis is endemic and empiric metronidazole is commonly the first-line response to chronic diarrhea in dialysis patients.<\/jats:p>","DOI":"10.1093\/omcr\/omag175","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:41:31Z","timestamp":1788522091000},"source":"Crossref","is-referenced-by-count":0,"title":["Sevelamer carbonate crystal associated colitis in a hemodialysis patient: a case report"],"prefix":"10.1093","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0783-2264","authenticated-orcid":false,"given":"Omair","family":"Bseiso","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Hebron University , Hebron, West Bank ,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u2019moun","family":"Qawasmeh","sequence":"additional","affiliation":[{"name":"Department of Nephrology , Hebron Governmental Hospital (Al-Alia), Hebron, West Bank ,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas","family":"Zahdeh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Hebron University , Hebron, West Bank ,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Obay","family":"Isayed","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, An-Najah National University , Nablus, West Bank ,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abrar","family":"Omari","sequence":"additional","affiliation":[{"name":"Prince Hamzah Hospital , Amman ,","place":["Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motaz","family":"Natsheh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Al Ahli Hospital , Hebron, West Bank ,","place":["Palestine"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"2026091415525392300_ref1","first-page":"1","article-title":"KDIGO 2017 clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD)","volume":"7","author":"KDIGO CKD-MBD Work Group","year":"2017","journal-title":"Kidney Int Suppl"},{"key":"2026091415525392300_ref2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/ckj\/sfx013","article-title":"Gastrointestinal complications induced by sevelamer crystals","volume":"10","author":"Yuste","year":"2017","journal-title":"Clin Kidney J"},{"key":"2026091415525392300_ref3","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1097\/PAS.0b013e3182999d8d","article-title":"Sevelamer crystals in the gastrointestinal tract (GIT): a new entity associated with mucosal injury","volume":"37","author":"Swanson","year":"2013","journal-title":"Am J Surg Pathol"},{"key":"2026091415525392300_ref4","doi-asserted-by":"publisher","first-page":"2615","DOI":"10.3748\/wjg.14.2615","article-title":"Lower gastrointestinal bleeding: association with sevelamer use","volume":"14","author":"Madan","year":"2008","journal-title":"World J Gastroenterol"},{"key":"2026091415525392300_ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/4646732","article-title":"Sevelamer carbonate crystal-induced colitis","volume":"2020","author":"Lai","year":"2020","journal-title":"Case Rep Gastrointest Med"},{"key":"2026091415525392300_ref6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000486192","article-title":"Sevelamer-induced gastrointestinal injury presenting as gastroenteritis","volume":"12","author":"Magee","year":"2018","journal-title":"Case Rep Gastroenterol"},{"key":"2026091415525392300_ref7","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12876-016-0441-4","article-title":"A case report of sevelamer-associated recto-sigmoid ulcers","volume":"16","author":"Tieu","year":"2016","journal-title":"BMC Gastroenterol"},{"key":"2026091415525392300_ref8","first-page":"1","article-title":"Colonic mucosal ulceration and gastrointestinal bleeding associated with sevelamer crystal deposition in a patient with end stage renal disease","volume":"2018","author":"Nambiar","year":"2018","journal-title":"Case Rep Nephrol"},{"key":"2026091415525392300_ref9","article-title":"Lower gastrointestinal bleeding in a patient receiving sevelamer: case report","volume":"9","author":"Schoot","year":"2021","journal-title":"SAGE Open Med Case Rep"},{"key":"2026091415525392300_ref10","doi-asserted-by":"crossref","first-page":"1097469","DOI":"10.3389\/fmed.2023.1097469","article-title":"Case report: sevelamer-associated colitis-a cause of pseudotumor formation with colon perforation and life-threatening bleeding","volume":"10","author":"Fistrek Prlic","year":"2023","journal-title":"Front Med (Lausanne)"}],"container-title":["Oxford Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2026\/9\/omag175\/71078319\/omag175.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/omcr\/article-pdf\/2026\/9\/omag175\/71078319\/omag175.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:52:58Z","timestamp":1789415578000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/omcr\/article\/doi\/10.1093\/omcr\/omag175\/8794363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/omcr\/omag175","relation":{},"ISSN":["2053-8855"],"issn-type":[{"value":"2053-8855","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,9,1]]},"article-number":"omag175"}}